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Figure 4
(a) The HI dimer complexed with m-cresol (PDB entry 9ibb), consisting of two insulin monomers, each bound to one m-cresol molecule and a zinc ion. (b) The phenolic pocket, where an m-cresol molecule forms hydrogen bonds with Cys6 and Cys11. (c) The 2Fo − Fc electron-density map contoured at 1.0σ, highlighting the ligand density within the binding site.

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