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Figure 1
(a) Schematic image of segmentally deuterated ER-60 comprising partially deuterated (ca 75%) bb′ domains (gray) and hydrogenated a and a′ domains (red). The SLD of partially deuterated bb′ domains matches that of 100% D2O, rendering them `scattering invisible' in SANS. (b) Schematic illustration of SLD of hydrogenated and partially deuterated proteins. The double-headed arrow indicates the difference of SLD between 100% D2O and hydrogenated protein, termed the scattering contrast.

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