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Figure 8
Comparison of the intersubunit tunnel. (a) Superposition of SpTrpAB (yellow, TrpA, chain C; coral/cyan, TrpB, chain D) with ligand-free MtTrpAB (purple; chains A and B; PDB entry 5tcf; Wellington et al., 2017BB64). (b) Superposition of ligand-free MtTrpAB (purple; chains A and B; PDB entry 5tcf) with MtTrpAB in complex with BRD4592 (pink; chains C and D; PDB entry 5tci; Wellington et al., 2017BB64). Note that in the shown chain D TrpB adopts the βO state. Chain B exists as a mixture of the βO and βeO states. (c) Superposition of FtTrpAB (green, TrpA; blue/navy, TrpB) with StTrpAB (gray; PDB entry 1bks; Rhee et al., 1996BB53). (d) StTrpAB (gray; PDB entry 1bks) with StTrpAB in complex with F6 (black; PDB entry 4wx2; Hilario et al., 2016BB25). Key residues are shown in stick representation; inhibitors are shown in ball-and-stick representation.

Volume 6| Part 4| July 2019| Pages 649-664
ISSN: 2052-2525