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Figure 11
Ligand-binding sites of the structures obtained from on-chip ligand-soaking experiments using our crystallization chambers and Roadrunner I chips. (a) An aspartate molecule (pink) in complex with a sodium ion (purple sphere) is bound to the active site of thermolysin. It is involved in the fivefold coordination of the catalytic zinc ion (gray sphere) with both its amino and carboxy moieties. The 2mFoDFc electron-density map at 1σ is shown as a blue mesh and catalytically important thermolysin residues (green) are labeled. (b) The 2mFoDFc electron-density map at 1.5σ clearly indicates the presence of Mg2+-ADP (yellow sphere and pink sticks) at the active site of DRAK2.

Volume 6| Part 4| July 2019| Pages 714-728
ISSN: 2052-2525