Figure 1
Schematic diagram of the Complex-LCP method. After crystallization conditions have been identified and optimized, the target receptor is purified in complex with a transient ligand and screened against a panel of N ligands using nanolitre-volume high-throughput robotic crystallization in 96-well glass sandwich plates. Those ligands that support crystallization are then used to prepare samples for XFEL data collection in syringes. |