view article

Figure 3
Binding of propranolol and carvedilol to β2AR. (a) Superposition of propranolol-bound (cyan) and alprenolol-bound (pink) β2AR structures. (b) Chemical structure of carvedilol with contacting β2AR residues within 4 Å of the ligand. (c) Superposition of carvedilol-bound β2AR (green) and β1AR (orange; PDB entry 4amj; two molecules from one asymmetric unit; Warne et al., 2012) structures. (d) Superposition of carvedilol-bound (green) and carazolol-bound (yellow) β2AR structures. Hydrogen bonds are shown as dashed lines for the propranolol- and carvedilol-bound β2AR structures only. Helices are labeled with Roman numerals.

Volume 6| Part 6| November 2019| Pages 1106-1119
ISSN: 2052-2525