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Figure 4
Ligand exchange in 5-HT2B and A2AAR. (a, b) Ligand-exchange experiment in LCP crystallization plates with 5-HT2B. The transient ligand serotonin was exchanged for ERG (a) and DHE (b). The images were taken under cross-polarized light. No crystals appeared in control experiments (insets) set up without adding ligands to the precipitant solution. (c, d) Ligand-exchange experiment in glass syringes with A2AAR. The transient ligand LUF5834 is exchanged for ZM241385. (c) LCP string immersed in precipitant solution in a glass syringe. (d) LCP sample titrated with 7.9 MAG before loading into an LCP injector.

Volume 6| Part 6| November 2019| Pages 1106-1119
ISSN: 2052-2525