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Figure 1
Locations of the ten thermal-stabilized mutations. (a)–(d) The original structure of inactive GLP-1R in complex with PF-06372222 (PDB entry 5vew; Song et al., 2017BB33) is shown as a gray cartoon, with mutations as green sticks and other interacting residues as gray sticks. Mutations analyzed in the current study are underlined.

Volume 6| Part 6| November 2019| Pages 996-1006
ISSN: 2052-2525