Figure 6
Proposed DNA-binding mode. (a) Prediction_1 for the DNA-binding mode of the SaTatD dimer with 18-mer dsDNA. Prediction_1 suggests that owing to the dimeric interface, DNA has difficulty approaching the active site of SaTatD. DNA is shown as a ribbon diagram, and the DNA strands are colored wheat (3′–5′) and dark gray (5′–3′). (b) Prediction_2 for the DNA-binding mode of the SaTatD monomer with 3-mer dsDNA considering structural hindrance. Elongated DNA chains that may bind to the basic surface area (blue dotted circle) consisting of Loop2–Loop3 are displayed as wheat and dark gray dotted lines. |