The overall structure of the ESA–dexamethasone complex. The electron density observed for dexamethasone in DS7 is shown as a green mesh (mFo − DFc map, calculated after ten refinement cycles without the ligand, r.m.s.d. 2.5). Albumin subdomains are shown in different colors and labeled with Roman numerals and letters (e.g. IA). The dexamethasone molecule is shown in stick representation with C atoms in yellow, O atoms in red and the F atom in cyan. The chemical structure of dexamethasone is displayed in the same orientation as the stick representation. The electron density, including the OMIT maps, and the model can be inspected interactively at https://molstack.bioreproducibility.org/project/view/gmvG1L8c66YgPpgqS0Zm/.