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Figure 2
Quality and validation of the A2AAR model obtained in this study. (a) The ZM341385 binding site is conserved across all models. The ligand from our structure (green sticks) is shown with side chains from all structures aligned. (b) Conservation of the sodium binding site. The side chains from all the models are shown with the sodium (blue sphere) and waters (red spheres) from our current model. (c) 2mFoDFc map contoured at 1.0σ shows the density for ZM341385 in our model. (d) 2mFoDFc map contoured at 1.0 σ shows clear cholesterol densities in our model.

Volume 7| Part 6| November 2020| Pages 976-984
ISSN: 2052-2525