Cortisone and cortisol break hydrogen-bonding rules to make a drug–prodrug solid solution

Multidrug products enable more effective therapies and simpler administration regimens, provided that a stable formulation is prepared, with the desired composition. In this view, solid solutions have the advantage of combining the stability of a single crystalline phase with the potential of stoichiometry variation of a mixture. Here a drug–prodrug solid solution of cortisone and cortisol (hydrocortisone) is described. Despite the structural differences of the two components, the new phase is obtained both from solution and by supercritical CO₂ assisted spray drying. In particular, to enter the solid solution, hydrocortisone must violate Etter's rules for hydrogen bonding. As a result, its dissolution rate is almost doubled.

1. Introduction

Modern medical therapies rely on increasingly complex pharmaceutical regimens that include multiple drugs with synergistic or complementary effects. In the case of chronic conditions, such therapies may be continued throughout the patient's life. Multidrug formulations could reduce drug dosage and potential side effects whilst simplifying administration regimens (Aljuffali et al., 2016; Okuda & Kidoaki, 2012; Das et al., 2010). Such products can often be prepared as physical mixtures of the active pharmaceutical ingredients (APIs) in the desired dose, although the resulting multiphase system might be difficult to process and to store over time (Raimi-Abraham et al., 2017). Alternatively, a stable crystalline phase can be obtained by combining multiple active ingredients in a cocrystal (Kavanagh et al., 2019a; Bordignon et al., 2017). Cocrystals possess the advantages of a single phase but their fixed stoichiometry does not allow for the adjustment of the APIs dose, which is necessarily dictated by therapeutic considerations rather than crystallographic ones (Kavanagh et al., 2019b). A third approach can be imagined that involves crystalline molecular solid solutions (Lusi, 2018a), which combine the simplicity of a single crystalline phase with the stoichiometry variability of a physical mixture.

Solid solutions are commonly employed in inorganic chemistry and metallurgy, whereas their molecular subgroup remains largely understudied. Besides a few notable exceptions (Mishra et al., 2015; Braga et al., 2009; Delori et al., 2014), the dominant perception around these phases is that they are difficult to make (Lusi, 2018b). Indeed, empirical rules originally formulated by Hume-Rothery (1926) and Kitaigorodsky (1984) prescribe that only atoms and molecules of the same size, charge and shape can mutually substitute each other in the solid state. Moreover, complete solubility is only deemed possible for those compounds that produce isostructural (and/or isomorphous) crystals (Kitaigorodsky, 1984). In particular, it was suggested that in order to form a mixed crystal, molecules must have equivalent hydrogen-bond donors and acceptors. From a crystal-engineering perspective, such a requirement can be seen as a direct consequence of Etter's rule for hydrogen bonds: `All good proton donors and acceptors are used in hydrogen bonding' (Etter, 1990) – a rule that is generally followed in the known crystal structures with a few exceptions owing to steric hindrance (Wood & Galek, 2010). Ultimately, only a subset of molecules, often differing by a methyl or a halogen substituent, would fulfil Hume-Rothery and Kitaigorodsky prescriptions. Such conditions represent a bottleneck to the development of pharmaceutical solid solutions (Etter, 1990).

In contrast, recent work shows that appropriate design strategies can enable mixed crystals despite the lack of isostructurality (Schur et al., 2015) or large size difference (Lestari & Lusi, 2019) of the parent components. Other works show that the appropriate synthetic conditions could afford long-lasting metastable products – as an example, solvent-assisted grinding can afford solid solutions that are not available by conventional techniques (Chierotti et al., 2010). In fact, for non-stoichiometric systems, the complex equilibria between liquid and solid phases often hinders the preparation of a uniform product. In those cases, mechanochemical reactions might afford better control over the product by avoiding a liquid phase (Lusi, 2018b). Similarly, the kinetic control possible through rapid expansion of supercritical solutions (RESS) processes affords high miscibility in the solid solutions of anthracene/phenanthrene (Liu & Nagahama, 1996), L-leucine/L-isoleucine and L-leucine/L-valine (Raza et al., 2018).

With these premises we believe that the investigation of novel pharmaceutical solid solutions and their potential scale up by such methods is meritable of attention. In particular, we wanted to test whether solid solutions could be formed for molecules that have different hydrogen-bonding capabilities and are not isostructural. To this end, our attention was directed to two steroids: cortisone (C) and hydrocortisone (HC).

Owing to their extensive use in medicine, many steroids are synthesized and commercialized as slow-releasing formulations that help in maintaining the ideal blood concentration for prolonged periods of time (Paik et al., 2019; Krasselt & Baerwald, 2016). Over five decades ago, steroids were among the earliest APIs to be co-crystallized as solid solutions and eutectic mixtures (Rudel, 1974; Castellano et al., 1980). Interestingly, solid solutions are also reported for pairs of steroids such as arenobufagin/gamabufotalin and cinobufagin/cinobufotalin (Kálmán & Párkány, 1997), which are `essentially isostructural' despite their different hydrogen-bond capabilities. In fact, for large and non-polar molecules such as steroids, the role of dispersive forces may become predominant over hydrogen bonds (Thompson & Day, 2014).

C was the first steroid to be employed as a replacement in adrenocortical deficiency states (Benedek, 2011; Hench et al., 1949). Nowadays, it is largely substituted by its more soluble metabolite: cortisol (HC), the most widely used steroidal anti-inflammatory drug, listed by the World Health Organization as an essential medicine (Garay et al., 2007). For this drug, the topical market alone is estimated at ∼3 billion USD globally.

C and HC differ only in the substituent in the C11 position, a carbonyl and a hydroxyl moiety, respectively (Fig. 1), and their metabolism is closely related. In fact, C can be seen as a prodrug (Becker, 2001) of HC, being converted to the latter by the 11β-hydroxysteroid dehydrogenase (Lakshmi & Monder, 1985; Edwards et al., 1988). From a pharmaceutical perspective, it can be imagined that a solid form that includes both molecules could help maintain the desired plasma concentration for a prolonged period reducing the number of doses and simplifying their administration.

Figure 1 Schematic representations of C (left) and HC (right), with C atom numbering.

2. Results and discussion

2.1. Single-crystal analysis

Despite their similar biochemical functions, C and HC are rather different from a supramolecular point of view. They crystallize in different structures and show different polymorphism. C has only one known polymorph in the P2₁2₁2₁ space group [CCDC (Groom et al., 2016) refcode DHPRTO; Declercq et al., 1972], while three polymorphs of HC are known: forms I (CCDC refcode ZZZPNG01) and III (CCDC refcode ZZZPNG03) in the P2₁2₁2₁ space group and form II (CCDC refcode ZZZPNG02) in the monoclinic P2₁ space group (Suitchmezian et al., 2008). No evident structural similarity is recognisable in these structures (Kálmán & Párkány, 1997), phenomena that can be explained in terms of the different hydrogen-bond capabilities of the substituents, carbonyl and hydroxyl, on the C11.

Slow solvent evaporation of alcoholic solutions of C and HC in 2:1, 1:1 and 1:2 ratios provided colourless crystals. Single-crystal X-ray diffraction (XRD) revealed that the crystals are all isomorphous to the C structure (CCDC refcode DHPRTO). The C11–O11 bond lengths for the single crystals isolated from the solutions measure 1.25, 1.29 and 1.31 Å, respectively (Table 1). These values fall between those of pure C (C = O = 1.21 Å) and those of pure HC (C–O = 1.43 Å) and suggest the formation of a solid solution. The poor resolution of standard XRD does not allow for the refinement of the oxygen substituent as a split atom (carbonyl versus hydroxyl group), nor for the reliable refinement of hydrogen-atoms occupancy (Lusi & Barbour, 2011). Similarly, the single crystals are too small for high-performance liquid chromatography (HPLC) analysis. The occupancy refinement for the hydrogen atoms on C11 and on the adjacent O11 was attempted for a mere aesthetical end. The single crystals, isolated at the beginning of the crystallization, appear enriched in HC. Incidentally, when the C–O bond lengths are plotted against the calculated occupancy, a second-order relation emerges (see Fig. S1 in the Supporting information).

Table 1
Crystallographic data for single crystals of C, HC and their solid solutions

	C	C:HC ≃ 2:1	C:HC ≃ 1:2	C:HC ≃ 1:3	HC form I
a (Å)	7.7819 (4)	7.7442 (6)	7.7308 (7)	7.76953 (9)	10.1439 (14)
b (Å)	10.0468 (5)	10.0968 (8)	10.1237 (9)	10.1258 (11)	12.4255 (16)
c (Å)	23.6401 (13)	23.6750 (19)	23.694 (2)	23.694 (3)	30.496 (5)
Volume (Å^3)	1848.26 (17)	1851.2 (3)	1854.4 (3)	1854.4 (3)	3843.8 (10)
Space group	P212121	P212121	P212121	P212121	P212121
Moiety formula	C21H28O5	0.63(C21H28O5) 0.37(C21H30O5)	0.36(C21H28O5) 0.64(C21H30O5)	0.26(C21H28O5) 0.74(C21H30O5)	C21H30O5
Mr	360.43	361.18	361.71	361.92	359.42
Dx (g cm^−3)	1.295	1.296	1.296	1.306	1.242
Z	4	4	4	4	8
R (reflections)	0.0504 (3395)	0.0747 (2479)	0.0715 (1824)	0.0715 (1824)	0.0969 (931)
Temperature (K)	296	296	296	296	296
C–O distance (Å)	1.208	1.255	1.288	1.311	1.457
Hirshfeld plot of cortisone
Hirshfeld plot of hydrocortisone

A qualitative understanding of the structure modifications that occur with substitution can be proposed using Hirshfeld surface analysis. Here the (virtual) replacement of a HC molecule in the structure of C would result in a short H⋯H contact (∼1.8 Å) between the hydroxyl group O11 and C7 in the adjacent molecule (Fig. 2). This value is ∼20% shorter than the expected contact distance based on the Bondi radius (1.1 Å). At the same time, any rotation of the OH group is sterically hindered by the presence of the adjacent methyl carbons C18 and C19, which suggests that the substitution would rapidly increase the enthalpy of the crystal. As a response, when the amount of HC increases, the structure progressively relaxes to accommodate the bulkier hydroxyl substituent (Table 1). The structure adjustments have negligible effects on the contact surface of C but the H⋯H contact distance for HC increases to above 2 Å. A similar phenomenon was observed in the phenazine/acridine system, confirming the importance of structure modulability for the successful realization of solid solutions (Schur et al., 2015).

Figure 2 Part of the packing features of HC in the structure of C. The green molecule is generated by translation along a and the purple molecule is generated by screw symmetry along b.

The correct identification and quantification of all the energy contributions in such a disordered system is not straightforward and it is beyond the scope of this work, though an estimate of the energies can be performed in Crystal Explorer (Turner et al., 2017) for the C and HC molecules in the different structures. The results indicate that the overall interaction energy for the HC molecule in the structure of pure C is ∼12 kJ mol⁻¹ higher than that of the C molecule (see Table S1 in the Supporting information). The main difference is caused by the higher repulsion occurring with another HC molecule related by simple translation along the a axis (identified as x, y and z in Table S1 and coloured in green in Fig. 2). Although, part of the repulsion is compensated by a greater dispersive contribution. As the substitution increases and the structure adjusts, the repulsion contribution between this pair of HC molecules is progressively reduced and, eventually, the total interaction energy calculated for HC becomes comparable with the one calculated for C. Notably, the structural and compositional variations along the series seem to have little effect on the other molecular interactions. Invariantly, the largest contribution to the molecular packing comes from the dispersive interaction with the molecule along the b screw axis (identified as −x, y + 1/2, −z + 1/2 in Table S1 and coloured in violet in Fig. 2).

2.2. Bulk synthesis and properties

Based on previous experience, solvent assisted co-grinding of the two molecules was attempted to make a bulk product with homogenous 2:1, 1:1 and 1:2 ratio compositions. The persistence of a diffraction peak at 17.5° shows that a phase mixture was obtained (Fig. 3). Such qualitative conclusions are confirmed by Rietveld refinement, according to which the relative amount of each phase coincides with that of the starting materials (Table S1). On the contrary, the same technique indicates that a single microcrystalline phase is obtained when CO₂ is employed in a supercritical CO₂ assisted spray drying (SASD) process (Long et al., 2019, 2020; Padrela et al., 2017) (Fig. 3). In this case, peak broadening indicates smaller crystallites.

Figure 3 Powder XRD patterns measured for microcrystalline powder generated by the SASD method (blue) and the mechanochemical product (red).

The spray-drying methods ensure that the overall stoichiometry of the microcrystalline product coincides with that of the liquid phase. Within the bulk, product uniformity is confirmed by solid-state nuclear magnetic resonance (SSNMR). ¹³C cross-polarization magic angle spinning (CPMAS) spectra of the solid solutions are consistent with those of pure C, but with apparent differences, especially in the number of signals (Fig. 4). This agrees with the fact that the structure of pure C is maintained in the solid solutions, with HC as a guest molecule. The homogeneous nature of the microcrystalline product was further confirmed by ¹H T₁ relaxation measurements acquired through ¹³C (not shown). Indeed, the ¹H T₁ values are the same for each ¹³C signal, indicating active spin diffusion processes, i.e. homogeneous domains over a 100 nm scale. The CPMAS technique is intrinsically non-quantitative, since the intensity of each spectral resonance depends both on their T_XH (the cross-polarization rate) and their T_1ρ^H (the proton spin-lattice relaxation in the rotating frame). However, the two CH groups in C and HC are the same functional group (namely, the olefinic CH group – C4), in the same chemical environment of two almost identical and rigid molecules (or in any case with very similar mobility) in the same unit cell. Therefore, it is reasonable and safe to think that the two CH groups in the two molecules have almost identical T_XH and T_1ρ^H values and the same cross-polarization rate. Thus, ¹³C spectra were used to achieve reliable quantitative information (Anelli et al., 2019). Specifically, in order to assess the relative amounts of C and HC in the solid solutions, a deconvolution was performed on the signals in the 120–130 p.p.m. range. By considering the resonances to be the result of slightly different contributions, the deconvolution allowed the determination of the C:HC ratio for the SASD products, in accordance with the nominal ones (see Fig. S3).

Figure 4 ^13C (100.63 MHz) CPMAS SSNMR spectra measured for the microcrystalline powder generated by the SASD method. The labels refer to assignments of relevant peaks (see Fig. 1 for atom numbering).

Thermal analyses reveal that the solid solutions are marginally lower melting than the pure compounds but remain stable until ∼180 °C (see Figs. S4 and S5). Finally, the solubility of the new phase was assessed by measuring the intrinsic solubility of C and HC in the solid solution and physical mixture. Notably, in the solid solution the initial dissolution rate of HC is twice that of pure HC (form I). On the contrary, the dissolution rate of C is reduced in the solid solution (Fig. 5). This agrees with the common understanding that the properties of solid solutions often vary regularly between those of the pure components.

Figure 5 Dissolution profiles of C and HC for the products generated by the SASD method.

3. Conclusions

Drug/prodrug solid solutions of C and HC were prepared in different stoichiometric ratios. The mixed-crystals results are stable in spite of the different hydrogen-bond capabilities of the two molecules and the different crystal structures of their pure phases. We believe that the formation of the solid solution is possible because in large and non-polar molecules the contribution of dispersive forces becomes predominant over that of hydrogen bonds. Moreover, the host structure of C can adjust to accommodate the hydroxyl group of the HC molecule. Interestingly, a uniform polycrystalline phase could be obtained by the SASD method, whereas the solvent evaporation and mechanochemical techniques resulted in a large compositional spread or a mixture of the pure components, respectively.

From a pharmaceutical point of view, the solid solution enables a faster dissolution rate of HC, which is up to twice that measured for the pure compound. We speculate that the higher solubility could increase the bioavailability of HC, while the compresence of C could prolong the desired concentration of the anti-inflammatory API in plasma. The variable ratio of the solid solutions would then allow the optimization of the correct dosage.

Ultimately, this work shows that mixed crystals represent a viable alternative to physical mixtures and cocrystals to formulate multidrug products. In particular, drug–prodrug solid solutions would be particularly targetable because of the structural similarity that is often observed between an active molecule and its biological precursors.

4. Experimental

All reagents grade products were used as purchased without further purification.

4.1. Solution synthesis

Single crystals of pure C and pure HC were recrystallized from a solution of ∼0.2 mmol (72 mg) of the commercial products in ethanol, by slow evaporation in ambient conditions. The mixed crystals of C and HC in the 2:1, 1:1 and 1:2 ratios were obtained in the same conditions from ethanol solutions containing: (a) 72.0 mg (0.2 mmol) of C and 36.3 mg (0.1 mmol) of HC, (b) 54.1 mg (0.15 mmol) of C and 54.4 mg (0.15 mmol) of HC, and (c) 36.1 mg (0.1 mmol) of C and 72.6 mg (0.2 mmol) of HC, respectively. Good-quality single crystals were isolated from the liquid phase as soon as they formed (within two or three days).

4.2. Mechanochemical synthesis

Solid-solution synthesis of C and HC in the 2:1, 1:1 and 1:2 ratios was attempted by manually grinding in an agate mortar: (a) 72.0 mg (0.2 mmol) of C and 36.3 mg (0.1 mmol) of HC, (b) 54.1 mg (0.15 mmol) of C and 54.4 mg (0.15 mmol) of HC, and (c) 36.1 mg (0.1 mmol) of C and 72.6 mg (0.2 mmol) of HC, respectively. In each case, four to five (Pasteur pipette) drops of ethanol were added to the mixture and machination continued until a dry powder was obtained (∼5–10 min).

4.3. SASD synthesis

Solutions of either pure C or HC where prepared by dissolving 150.0 mg of as-received powder in 20 ml of ethanol. Solutions of the mixed steroids in the 2:1, 1:1 and 1:2 ratios were prepared in 20 ml of ethanol by dissolving: (a) 100.0 mg (0.28 mmol) of C and 50.0 mg (0.14 mmol) of HC, (b) 75.0 mg (0.21 mmol) of C and 75.0 mg (0.21 mmol) of HC, and (c) 50.0 mg (0.14 mmol) of C and 100.0 mg (0.28 mmol) of HC, respectively. Full dissolution was completed in an ultrasonic bath (∼15 min). The solutions were then filtered through a 0.2 µm pore-size nylon filter (Whatman Inc., Florham Park, New Jersey). An Agilent Technologies 1260 Infinity II pump was used to pass the solutions at a flow rate of 0.2 ml min⁻¹ through a 0.1 cm³ high-pressure nozzle equilibrated at 70 °C with heating resistors. In the nozzle, the solutions were mixed with a stream of CO₂ compressed to 12 MPa using a SFE Process DoseHPP 400-C pump. The supercritical mixture was depressurized in a 1000 cm³ chamber in equilibrium with a water jacket at 70 °C, and the product collected on 0.2 µm filter paper. The samples were harvested and stored in a desiccator prior to characterization to prevent exposure to humidity that results in solid-state transformation over time.

4.4. XRD analysis

Single-crystal XRD was performed in Bruker D8 Quest single-crystal X-ray diffractometers with an Mo anode for C, and a Cu anode for HC. Measurements were taken at an ambient temperature. The intensities were integrated with SHELX and SAINT in the Bruker APEX3 (Bruker, 2016) suite of programs and a solution was found using direct methods. Atomic positions and occupancies were refined against all the F²_obs values, and all non-hydrogen atoms were treated anisotropically in SHELXL (Sheldrick, 2015) using the X-SEED (Barbour, 2001) interface.

Powder XRD patterns were collected on a X'Pert Pro instrument at 40 kV and 40 mA, with Cu Kα λ = 1.54056 Å in a θ°–θ° geometry. Data were measured from 4 and 40 2θ° with a step size of 0.0167113° and a scan time of 19.685 seconds step⁻¹. Samples were placed in a zero-background disc. Rietveld refinement for mixture samples was performed in HighScore Plus (Degen et al., 2014). Rietveld refinement was performed for the mixture samples against the pure C and HC crystal structures.

4.5. Hirshfeld surface analysis and energy calculation

Hirshfeld surface analysis was calculated with Crystal Explorer 17 (Turner et al. 2017) for the molecules of C and HC in the pure compounds and in the solid solutions. Since the hydrogen-atom position cannot be reliably refined by XRD, the hydrogen atoms were fixed according to the riding model and their bond lengths normalized to the average neutron data. In particular, for the HC molecule, the H-C11-O11-H torsion angle was fixed to 45°: the most common value obtained as a result of the structure refinement. This precaution allows a more direct comparison of the structural change as a function of composition.

Interaction energies were calculated in Crystal Explorer 17 for a cluster containing the reference molecule and neighbour molecules within a radius of 3.8 Å using the default setting and the HF/3-21G basis set.

4.6. Solid-state NMR

Solid-state NMR spectra were acquired with a Bruker Avance II 400 Ultra Shield instrument, operating at 400.23 and 100.63 MHz for ¹H and ¹³C nuclei, respectively

The powder samples were packed into cylindrical zirconia rotors with a 4 mm outer diameter and an 80 µl volume. A certain amount of sample was collected from each batch and used without further preparations to fill the rotor. ¹³C CPMAS spectra were acquired at room temperature at a spinning speed of 12 kHz, using a ramp cross-polarization pulse sequence with a 90° ¹H pulse of 3.6 µs, a contact time of 3 ms, optimized recycle delays ranging from 2.5–5.6 s and a number of scans in the range 200–6500, depending on the sample. For every spectrum, a two-pulse phase modulation decoupling scheme was used, with a radiofrequency field of 69.4 kHz. The ¹³C chemical shift scale was calibrated through the methylenic signal of external standard glycine (at 43.7 p.p.m.). As for the ¹³C T₁-¹H analysis of the 1:1 solid solution, ¹³C spectra were acquired for 320 scans with different relaxation delays, included in the range 0.2–60 s and calculated by Bruker TopSpin 2.1 software through an exponential algorithm.

In order to assess the relative amounts of C and HC in the solid solutions, a deconvolution was performed on the signals in the 120–130 p.p.m. range (Fig. 2). By considering the resonances to be the result of slightly different contributions, the deconvolution allowed us to determine that the C:HC ratio for the SASD products is equal to 66.0:34.0, 49.7:50.3 and 35.2:64.8, in accordance with the nominal ones (2:1, 1:1 and 1:2, respectively).

4.7. Thermal analysis

Thermogravimetric analysis was performed on a TA Instrument Q50 with aluminium sample pans. Samples were heated to 400 °C with a rate of 10 °C min⁻¹ and nitrogen gas flow rates of 60 ml min⁻¹. Differential scanning calorimetry was performed on a TA Instrument Q2000 in sealed aluminium pans with a heating rate of 10 °C min⁻¹ and nitrogen gas flow rates of 60 ml min⁻¹.

4.8. Solubility measurements

Intrinsic solubility measurements were performed in sink conditions. 20 mg of each sample was dissolved in 1000 ml of deionized water at 37 °C at 150 rev min⁻¹. The sample was collected at minutes 1, 3, 5, 10, 15, 30, 45 and 60 and filtered through a 0.2 µm nylon filter. The HPLC system used was Agilent Technologies 1260 Infinity with column Macherey-Nagel EC100/4.6 Nucleodur 100-5C18ec. The mobile phase used was methanol and water with a ratio of 1:1 at 1.0 ml min⁻¹ flow rate. 20 µl of the sample was injected into the HPLC system. The system and the autosampler were at an ambient temperature. Chromatograms were recorded at 248 nm with a run time of 12 min. The processing of the chromatographic data was carried out in the software Chemstation for liquid chromatography (Agilent Technologies).

Supporting information

Computing details

For all structures, program(s) used to refine structure: SHELXL2014/7 (Sheldrick, 2014).

(C_KL1_C)

Crystal data

C21H28O5	Dx = 1.295 Mg m^−3
Mr = 360.43	Mo Kα radiation, λ = 0.71073 Å
Orthorhombic, P212121	Cell parameters from 623 reflections
a = 7.7819 (4) Å	θ = 2–20°
b = 10.0468 (5) Å	µ = 0.09 mm^−1
c = 23.6401 (13) Å	T = 296 K
V = 1848.26 (17) Å^3	Prism, colourless
Z = 4	0.2 × 0.1 × 0.1 mm
F(000) = 776

Data collection

Bruker d8 quest diffractometer	Rint = 0.036
Absorption correction: multi-scan sadabs	θmax = 30.5°, θmin = 2.7°
Tmin = 0.715, Tmax = 0.746	h = −11→11
20384 measured reflections	k = −8→13
5481 independent reflections	l = −33→33
3995 reflections with I > 2σ(I)

Refinement

Refinement on F^2	Hydrogen site location: inferred from neighbouring sites
Least-squares matrix: full	H-atom parameters constrained
R[F^2 > 2σ(F^2)] = 0.050	w = 1/[σ^2(Fo^2) + (0.0687P)^2 + 0.018P] where P = (Fo^2 + 2Fc^2)/3
wR(F^2) = 0.127	(Δ/σ)max < 0.001
S = 1.03	Δρmax = 0.21 e Å^−3
5481 reflections	Δρmin = −0.19 e Å^−3
239 parameters	Absolute structure: Flack x determined using 1309 quotients [(I+)-(I-)]/[(I+)+(I-)] (Parsons, Flack and Wagner, Acta Cryst. B69 (2013) 249-259).
0 restraints	Absolute structure parameter: −0.5 (4)

Special details

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Ų)

	x	y	z	Uiso*/Ueq
C1	0.0474 (3)	0.3213 (3)	0.86522 (10)	0.0509 (7)
H1A	−0.0535	0.3719	0.8544	0.061*
H1B	0.0427	0.2367	0.8456	0.061*
C2	0.0402 (4)	0.2953 (3)	0.92885 (11)	0.0518 (7)
H2A	0.0330	0.3793	0.9490	0.062*
H2B	−0.0615	0.2436	0.9378	0.062*
O3	0.1910 (4)	0.1308 (2)	0.98169 (10)	0.0756 (7)
C3	0.1951 (4)	0.2222 (3)	0.94707 (10)	0.0472 (6)
C4	0.3567 (3)	0.2643 (2)	0.92148 (10)	0.0387 (5)
H4	0.4587	0.2326	0.9369	0.046*
C5	0.3661 (3)	0.3461 (2)	0.87698 (9)	0.0302 (5)
C6	0.5358 (3)	0.3933 (2)	0.85490 (10)	0.0380 (5)
H6A	0.6273	0.3500	0.8758	0.046*
H6B	0.5455	0.4884	0.8611	0.046*
C7	0.5577 (3)	0.3640 (3)	0.79205 (10)	0.0386 (5)
H7A	0.6632	0.4051	0.7789	0.046*
H7B	0.5685	0.2687	0.7867	0.046*
C8	0.4085 (3)	0.4149 (2)	0.75649 (9)	0.0278 (4)
H8	0.4086	0.5124	0.7568	0.033*
C9	0.2369 (3)	0.3634 (2)	0.78192 (9)	0.0291 (4)
H9	0.2442	0.2661	0.7802	0.035*
C10	0.2084 (3)	0.3971 (2)	0.84553 (9)	0.0320 (5)
O11	−0.0314 (2)	0.4699 (2)	0.75665 (8)	0.0642 (6)
C11	0.0887 (3)	0.4010 (3)	0.74278 (10)	0.0408 (5)
C12	0.1055 (3)	0.3482 (3)	0.68288 (10)	0.0430 (6)
H12A	0.0072	0.3752	0.6604	0.052*
H12B	0.1109	0.2518	0.6832	0.052*
C13	0.2712 (3)	0.40623 (19)	0.65785 (8)	0.0289 (4)
C14	0.4222 (3)	0.3658 (2)	0.69566 (9)	0.0288 (4)
H14	0.4219	0.2683	0.6973	0.035*
C15	0.5793 (3)	0.4057 (3)	0.66075 (10)	0.0417 (5)
H15A	0.6783	0.3521	0.6708	0.050*
H15B	0.6071	0.4989	0.6665	0.050*
C16	0.5244 (3)	0.3797 (3)	0.59909 (11)	0.0421 (6)
H16A	0.5891	0.3059	0.5834	0.051*
H16B	0.5454	0.4580	0.5761	0.051*
O17	0.2993 (3)	0.20737 (14)	0.60257 (7)	0.0431 (4)
H17	0.3448	0.1707	0.5754	0.052*
C17	0.3309 (3)	0.3466 (2)	0.59999 (9)	0.0322 (5)
C18	0.2529 (4)	0.5579 (2)	0.65260 (11)	0.0457 (6)
H18A	0.2335	0.5957	0.6894	0.069*
H18B	0.1576	0.5785	0.6284	0.069*
H18C	0.3563	0.5945	0.6368	0.069*
C19	0.1923 (4)	0.5468 (2)	0.85717 (12)	0.0531 (7)
H19A	0.1989	0.5624	0.8972	0.080*
H19B	0.0840	0.5783	0.8431	0.080*
H19C	0.2840	0.5932	0.8385	0.080*
O20	0.2765 (3)	0.5048 (2)	0.52600 (9)	0.0681 (6)
C20	0.2317 (3)	0.4050 (2)	0.54990 (10)	0.0395 (5)
O21	−0.0163 (3)	0.3992 (2)	0.48742 (9)	0.0665 (7)
H21	−0.0494	0.4728	0.4978	0.080*
C21	0.0681 (4)	0.3356 (3)	0.53215 (12)	0.0558 (7)
H21A	0.0953	0.2451	0.5210	0.067*
H21B	−0.0090	0.3310	0.5644	0.067*

Atomic displacement parameters (Ų)

	U^11	U^22	U^33	U^12	U^13	U^23
C1	0.0323 (14)	0.091 (2)	0.0293 (13)	−0.0153 (14)	0.0023 (11)	−0.0033 (13)
C2	0.0433 (16)	0.0837 (19)	0.0283 (12)	−0.0168 (14)	0.0079 (11)	−0.0077 (12)
O3	0.0900 (18)	0.0814 (14)	0.0554 (13)	−0.0234 (13)	0.0079 (13)	0.0230 (12)
C3	0.0570 (18)	0.0569 (14)	0.0279 (12)	−0.0166 (13)	0.0028 (12)	−0.0037 (11)
C4	0.0407 (14)	0.0442 (12)	0.0312 (12)	−0.0019 (10)	−0.0023 (10)	−0.0013 (10)
C5	0.0315 (11)	0.0330 (9)	0.0262 (11)	−0.0031 (9)	−0.0025 (9)	−0.0061 (8)
C6	0.0280 (11)	0.0504 (13)	0.0356 (12)	−0.0066 (10)	−0.0063 (10)	0.0039 (10)
C7	0.0199 (10)	0.0584 (13)	0.0374 (13)	−0.0005 (10)	0.0010 (9)	0.0068 (10)
C8	0.0234 (10)	0.0328 (9)	0.0273 (10)	−0.0028 (8)	−0.0012 (8)	0.0016 (8)
C9	0.0245 (10)	0.0387 (10)	0.0240 (10)	−0.0028 (9)	0.0007 (8)	−0.0039 (8)
C10	0.0268 (11)	0.0434 (11)	0.0257 (10)	−0.0011 (9)	−0.0011 (9)	−0.0046 (9)
O11	0.0312 (9)	0.1224 (18)	0.0390 (11)	0.0213 (11)	0.0008 (8)	−0.0068 (11)
C11	0.0196 (10)	0.0737 (15)	0.0291 (11)	−0.0048 (11)	0.0010 (9)	−0.0034 (11)
C12	0.0273 (12)	0.0730 (16)	0.0288 (12)	−0.0116 (11)	−0.0025 (10)	−0.0056 (11)
C13	0.0269 (11)	0.0347 (10)	0.0251 (10)	−0.0003 (9)	0.0007 (8)	−0.0008 (8)
C14	0.0256 (10)	0.0321 (9)	0.0288 (10)	−0.0005 (8)	0.0026 (9)	0.0029 (8)
C15	0.0293 (12)	0.0604 (14)	0.0355 (13)	−0.0027 (11)	0.0049 (10)	0.0058 (11)
C16	0.0361 (13)	0.0562 (14)	0.0340 (13)	0.0026 (11)	0.0113 (10)	0.0043 (11)
O17	0.0654 (13)	0.0294 (7)	0.0346 (9)	0.0009 (7)	0.0080 (9)	−0.0045 (6)
C17	0.0393 (13)	0.0305 (9)	0.0267 (11)	−0.0018 (9)	0.0043 (10)	−0.0001 (8)
C18	0.0600 (17)	0.0378 (11)	0.0394 (13)	0.0125 (12)	−0.0061 (12)	−0.0024 (10)
C19	0.0629 (19)	0.0508 (14)	0.0456 (16)	0.0206 (13)	−0.0057 (14)	−0.0129 (11)
O20	0.0790 (16)	0.0733 (13)	0.0519 (12)	−0.0156 (12)	−0.0116 (11)	0.0296 (11)
C20	0.0496 (15)	0.0435 (12)	0.0254 (11)	0.0006 (11)	0.0015 (11)	−0.0001 (9)
O21	0.0894 (17)	0.0612 (12)	0.0488 (12)	0.0181 (11)	−0.0347 (12)	−0.0206 (10)
C21	0.067 (2)	0.0632 (16)	0.0369 (14)	−0.0076 (15)	−0.0172 (14)	−0.0032 (12)

Geometric parameters (Å, º)

C1—C2	1.528 (3)	C12—H12A	0.9700
C1—C10	1.538 (3)	C12—H12B	0.9700
C1—H1A	0.9700	C13—C14	1.531 (3)
C1—H1B	0.9700	C13—C18	1.536 (3)
C2—C3	1.476 (4)	C13—C17	1.564 (3)
C2—H2A	0.9700	C14—C15	1.528 (3)
C2—H2B	0.9700	C14—H14	0.9800
O3—C3	1.230 (3)	C15—C16	1.541 (4)
C3—C4	1.458 (4)	C15—H15A	0.9700
C4—C5	1.337 (3)	C15—H15B	0.9700
C4—H4	0.9300	C16—C17	1.542 (4)
C5—C6	1.497 (3)	C16—H16A	0.9700
C5—C10	1.524 (3)	C16—H16B	0.9700
C6—C7	1.524 (3)	O17—C17	1.422 (2)
C6—H6A	0.9700	O17—H17	0.8200
C6—H6B	0.9700	C17—C20	1.531 (3)
C7—C8	1.522 (3)	C18—H18A	0.9600
C7—H7A	0.9700	C18—H18B	0.9600
C7—H7B	0.9700	C18—H18C	0.9600
C8—C14	1.524 (3)	C19—H19A	0.9600
C8—C9	1.553 (3)	C19—H19B	0.9600
C8—H8	0.9800	C19—H19C	0.9600
C9—C11	1.526 (3)	O20—C20	1.203 (3)
C9—C10	1.557 (3)	C20—C21	1.511 (4)
C9—H9	0.9800	O21—C21	1.399 (3)
C10—C19	1.533 (3)	O21—H21	0.8200
O11—C11	1.208 (3)	C21—H21A	0.9700
C11—C12	1.518 (3)	C21—H21B	0.9700
C12—C13	1.534 (3)
C2—C1—C10	114.4 (2)	C11—C12—H12B	110.2
C2—C1—H1A	108.7	C13—C12—H12B	110.2
C10—C1—H1A	108.7	H12A—C12—H12B	108.5
C2—C1—H1B	108.7	C14—C13—C12	108.61 (17)
C10—C1—H1B	108.7	C14—C13—C18	112.42 (19)
H1A—C1—H1B	107.6	C12—C13—C18	109.3 (2)
C3—C2—C1	110.0 (2)	C14—C13—C17	100.41 (17)
C3—C2—H2A	109.7	C12—C13—C17	116.23 (17)
C1—C2—H2A	109.7	C18—C13—C17	109.70 (18)
C3—C2—H2B	109.7	C8—C14—C15	118.73 (19)
C1—C2—H2B	109.7	C8—C14—C13	114.27 (17)
H2A—C2—H2B	108.2	C15—C14—C13	103.23 (17)
O3—C3—C4	121.0 (3)	C8—C14—H14	106.6
O3—C3—C2	123.0 (3)	C15—C14—H14	106.6
C4—C3—C2	116.0 (2)	C13—C14—H14	106.6
C5—C4—C3	123.5 (2)	C14—C15—C16	104.17 (19)
C5—C4—H4	118.3	C14—C15—H15A	110.9
C3—C4—H4	118.3	C16—C15—H15A	110.9
C4—C5—C6	121.1 (2)	C14—C15—H15B	110.9
C4—C5—C10	123.2 (2)	C16—C15—H15B	110.9
C6—C5—C10	115.71 (18)	H15A—C15—H15B	108.9
C5—C6—C7	112.21 (18)	C15—C16—C17	107.09 (19)
C5—C6—H6A	109.2	C15—C16—H16A	110.3
C7—C6—H6A	109.2	C17—C16—H16A	110.3
C5—C6—H6B	109.2	C15—C16—H16B	110.3
C7—C6—H6B	109.2	C17—C16—H16B	110.3
H6A—C6—H6B	107.9	H16A—C16—H16B	108.6
C8—C7—C6	112.83 (19)	C17—O17—H17	109.5
C8—C7—H7A	109.0	O17—C17—C20	108.84 (19)
C6—C7—H7A	109.0	O17—C17—C16	112.46 (19)
C8—C7—H7B	109.0	C20—C17—C16	113.5 (2)
C6—C7—H7B	109.0	O17—C17—C13	106.73 (17)
H7A—C7—H7B	107.8	C20—C17—C13	112.31 (18)
C7—C8—C14	111.03 (18)	C16—C17—C13	102.69 (18)
C7—C8—C9	109.31 (18)	C13—C18—H18A	109.5
C14—C8—C9	108.53 (17)	C13—C18—H18B	109.5
C7—C8—H8	109.3	H18A—C18—H18B	109.5
C14—C8—H8	109.3	C13—C18—H18C	109.5
C9—C8—H8	109.3	H18A—C18—H18C	109.5
C11—C9—C8	109.42 (18)	H18B—C18—H18C	109.5
C11—C9—C10	115.09 (18)	C10—C19—H19A	109.5
C8—C9—C10	115.06 (17)	C10—C19—H19B	109.5
C11—C9—H9	105.4	H19A—C19—H19B	109.5
C8—C9—H9	105.4	C10—C19—H19C	109.5
C10—C9—H9	105.4	H19A—C19—H19C	109.5
C5—C10—C19	107.9 (2)	H19B—C19—H19C	109.5
C5—C10—C1	109.98 (19)	O20—C20—C21	119.9 (2)
C19—C10—C1	111.4 (2)	O20—C20—C17	122.5 (2)
C5—C10—C9	106.45 (17)	C21—C20—C17	117.6 (2)
C19—C10—C9	113.48 (19)	C21—O21—H21	109.5
C1—C10—C9	107.48 (17)	O21—C21—C20	113.2 (2)
O11—C11—C12	121.3 (2)	O21—C21—H21A	108.9
O11—C11—C9	124.2 (2)	C20—C21—H21A	108.9
C12—C11—C9	114.5 (2)	O21—C21—H21B	108.9
C11—C12—C13	107.44 (18)	C20—C21—H21B	108.9
C11—C12—H12A	110.2	H21A—C21—H21B	107.7
C13—C12—H12A	110.2

(KL4)

Crystal data

C21H28.74O5	Dx = 1.296 Mg m^−3
Mr = 361.18	Mo Kα radiation, λ = 0.71073 Å
Orthorhombic, P212121	Cell parameters from 72 reflections
a = 7.7442 (6) Å	θ = 2–20°
b = 10.0968 (8) Å	µ = 0.09 mm^−1
c = 23.6750 (19) Å	T = 296 K
V = 1851.2 (3) Å^3	Prism, colourless
Z = 4	0.1 × 0.1 × 0.05 mm
F(000) = 779

Data collection

Bruker d8 quest diffractometer	Rint = 0.067
Absorption correction: multi-scan sadabs	θmax = 30.5°, θmin = 2.7°
Tmin = 0.635, Tmax = 0.746	h = −11→6
9745 measured reflections	k = −14→13
5591 independent reflections	l = −33→25
2479 reflections with I > 2σ(I)

Refinement

Refinement on F^2	Hydrogen site location: inferred from neighbouring sites
Least-squares matrix: full	H-atom parameters constrained
R[F^2 > 2σ(F^2)] = 0.075	w = 1/[σ^2(Fo^2) + (0.039P)^2] where P = (Fo^2 + 2Fc^2)/3
wR(F^2) = 0.161	(Δ/σ)max < 0.001
S = 0.98	Δρmax = 0.24 e Å^−3
5591 reflections	Δρmin = −0.20 e Å^−3
241 parameters	Absolute structure: Flack x determined using 608 quotients [(I+)-(I-)]/[(I+)+(I-)] (Parsons, Flack and Wagner, Acta Cryst. B69 (2013) 249-259).
0 restraints	Absolute structure parameter: 2.7 (10)

Special details

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Ų)

	x	y	z	Uiso*/Ueq	Occ. (<1)
C1	0.0440 (6)	0.3205 (6)	0.86516 (19)	0.0557 (16)
H1A	−0.0577	0.3698	0.8538	0.067*
H1B	0.0410	0.2358	0.8458	0.067*
C2	0.0347 (7)	0.2956 (6)	0.92883 (19)	0.0556 (16)
H2A	0.0287	0.3794	0.9488	0.067*
H2B	−0.0683	0.2451	0.9378	0.067*
O3	0.1858 (5)	0.1303 (4)	0.98178 (16)	0.0776 (13)
C3	0.1912 (7)	0.2209 (6)	0.94694 (19)	0.0514 (14)
C4	0.3540 (6)	0.2625 (5)	0.92162 (18)	0.0393 (12)
H4	0.4561	0.2302	0.9371	0.047*
C5	0.3647 (6)	0.3447 (4)	0.87727 (16)	0.0309 (10)
C6	0.5343 (5)	0.3942 (5)	0.85614 (18)	0.0427 (12)
H6A	0.6267	0.3516	0.8770	0.051*
H6B	0.5421	0.4888	0.8628	0.051*
C7	0.5572 (6)	0.3664 (5)	0.79290 (18)	0.0444 (13)
H7A	0.6628	0.4082	0.7800	0.053*
H7B	0.5692	0.2717	0.7873	0.053*
C8	0.4069 (5)	0.4165 (4)	0.75712 (16)	0.0321 (10)
H8	0.4058	0.5136	0.7575	0.039*
C9	0.2351 (5)	0.3637 (4)	0.78205 (16)	0.0326 (10)
H9	0.2457	0.2671	0.7806	0.039*
C10	0.2047 (5)	0.3965 (4)	0.84583 (16)	0.0326 (10)
O11	−0.0186 (5)	0.4883 (5)	0.75406 (16)	0.0794 (14)
H11	−0.0946	0.4904	0.7300	0.095*	0.37 (5)
C11	0.0848 (6)	0.3961 (6)	0.74309 (19)	0.0505 (13)
H11A	0.0096	0.3236	0.7555	0.061*	0.37 (5)
C12	0.1054 (6)	0.3494 (6)	0.68241 (17)	0.0462 (14)
H12A	0.0077	0.3787	0.6600	0.055*
H12B	0.1093	0.2534	0.6813	0.055*
C13	0.2724 (5)	0.4064 (4)	0.65804 (16)	0.0304 (10)
C14	0.4232 (5)	0.3676 (5)	0.69638 (16)	0.0317 (10)
H14	0.4225	0.2706	0.6983	0.038*
C15	0.5829 (6)	0.4056 (6)	0.66180 (18)	0.0475 (13)
H15A	0.6814	0.3518	0.6724	0.057*
H15B	0.6117	0.4982	0.6673	0.057*
C16	0.5302 (6)	0.3788 (5)	0.60003 (19)	0.0439 (12)
H16A	0.5952	0.3047	0.5849	0.053*
H16B	0.5525	0.4561	0.5768	0.053*
O17	0.3035 (5)	0.2073 (3)	0.60334 (13)	0.0470 (9)
H17	0.3483	0.1710	0.5761	0.056*
C17	0.3341 (6)	0.3464 (4)	0.60053 (18)	0.0341 (10)
C18	0.2557 (7)	0.5567 (4)	0.65183 (19)	0.0498 (14)
H18A	0.2373	0.5958	0.6883	0.075*
H18B	0.1596	0.5769	0.6277	0.075*
H18C	0.3597	0.5918	0.6356	0.075*
C19	0.1897 (8)	0.5455 (5)	0.8583 (2)	0.0627 (16)
H19A	0.2072	0.5607	0.8979	0.094*
H19B	0.0770	0.5761	0.8476	0.094*
H19C	0.2756	0.5927	0.8371	0.094*
O20	0.2825 (5)	0.5018 (4)	0.52541 (15)	0.0710 (12)
C20	0.2376 (7)	0.4036 (5)	0.54976 (18)	0.0425 (12)
O21	−0.0136 (6)	0.3977 (4)	0.48722 (15)	0.0686 (12)
H21	−0.0259	0.4765	0.4947	0.082*
C21	0.0713 (7)	0.3343 (6)	0.5321 (2)	0.0587 (15)
H21A	0.0981	0.2441	0.5211	0.070*
H21B	−0.0059	0.3303	0.5643	0.070*

Atomic displacement parameters (Ų)

	U^11	U^22	U^33	U^12	U^13	U^23
C1	0.040 (3)	0.098 (5)	0.030 (2)	−0.015 (3)	0.005 (2)	−0.007 (3)
C2	0.043 (3)	0.092 (5)	0.032 (3)	−0.017 (3)	0.007 (2)	−0.007 (3)
O3	0.091 (3)	0.083 (3)	0.058 (2)	−0.022 (3)	0.014 (2)	0.026 (2)
C3	0.063 (4)	0.066 (4)	0.026 (2)	−0.014 (3)	0.005 (3)	−0.006 (3)
C4	0.043 (3)	0.045 (3)	0.030 (2)	−0.003 (2)	0.000 (2)	−0.003 (2)
C5	0.032 (2)	0.038 (3)	0.022 (2)	−0.002 (2)	−0.0003 (18)	−0.0060 (19)
C6	0.034 (3)	0.055 (3)	0.039 (3)	−0.005 (3)	−0.007 (2)	0.002 (3)
C7	0.026 (2)	0.066 (4)	0.041 (3)	−0.005 (2)	−0.005 (2)	0.009 (3)
C8	0.029 (2)	0.035 (2)	0.032 (2)	−0.006 (2)	−0.0011 (19)	0.001 (2)
C9	0.034 (2)	0.040 (3)	0.0241 (19)	0.002 (2)	−0.0007 (19)	−0.0037 (19)
C10	0.031 (2)	0.043 (3)	0.024 (2)	0.000 (2)	−0.0007 (19)	−0.006 (2)
O11	0.052 (2)	0.134 (4)	0.051 (2)	0.046 (3)	−0.0146 (18)	−0.022 (3)
C11	0.033 (3)	0.086 (4)	0.032 (2)	0.006 (3)	0.001 (2)	−0.004 (3)
C12	0.030 (3)	0.077 (4)	0.031 (2)	−0.007 (3)	−0.003 (2)	−0.007 (3)
C13	0.028 (2)	0.037 (3)	0.025 (2)	0.003 (2)	0.0013 (18)	−0.0019 (19)
C14	0.026 (2)	0.037 (3)	0.031 (2)	−0.001 (2)	−0.0005 (19)	0.002 (2)
C15	0.032 (3)	0.068 (4)	0.042 (3)	−0.005 (3)	0.005 (2)	0.003 (3)
C16	0.042 (3)	0.053 (3)	0.036 (2)	0.005 (3)	0.009 (2)	0.002 (2)
O17	0.070 (2)	0.0341 (19)	0.0370 (18)	0.0005 (17)	0.0102 (18)	−0.0031 (15)
C17	0.042 (3)	0.031 (2)	0.029 (2)	−0.003 (2)	0.006 (2)	0.000 (2)
C18	0.066 (3)	0.043 (3)	0.040 (3)	0.011 (3)	−0.003 (3)	0.000 (2)
C19	0.081 (4)	0.054 (3)	0.053 (3)	0.027 (3)	−0.010 (3)	−0.018 (3)
O20	0.082 (3)	0.076 (3)	0.054 (2)	−0.012 (3)	−0.013 (2)	0.034 (2)
C20	0.052 (3)	0.048 (3)	0.028 (2)	0.003 (3)	0.006 (2)	0.001 (2)
O21	0.093 (3)	0.062 (3)	0.051 (2)	0.019 (3)	−0.035 (2)	−0.023 (2)
C21	0.069 (4)	0.067 (4)	0.040 (3)	−0.008 (3)	−0.014 (3)	−0.006 (3)

Geometric parameters (Å, º)

C1—C2	1.530 (6)	C12—C13	1.528 (6)
C1—C10	1.532 (6)	C12—H12A	0.9700
C1—H1A	0.9700	C12—H12B	0.9700
C1—H1B	0.9700	C13—C18	1.530 (6)
C2—C3	1.491 (7)	C13—C14	1.531 (6)
C2—H2A	0.9700	C13—C17	1.565 (5)
C2—H2B	0.9700	C14—C15	1.531 (6)
O3—C3	1.233 (6)	C14—H14	0.9800
C3—C4	1.458 (7)	C15—C16	1.542 (6)
C4—C5	1.341 (6)	C15—H15A	0.9700
C4—H4	0.9300	C15—H15B	0.9700
C5—C6	1.492 (6)	C16—C17	1.553 (6)
C5—C10	1.537 (6)	C16—H16A	0.9700
C6—C7	1.533 (6)	C16—H16B	0.9700
C6—H6A	0.9700	O17—C17	1.426 (5)
C6—H6B	0.9700	O17—H17	0.8200
C7—C8	1.525 (5)	C17—C20	1.529 (6)
C7—H7A	0.9700	C18—H18A	0.9600
C7—H7B	0.9700	C18—H18B	0.9600
C8—C14	1.526 (5)	C18—H18C	0.9600
C8—C9	1.550 (5)	C19—H19A	0.9600
C8—H8	0.9800	C19—H19B	0.9600
C9—C11	1.521 (6)	C19—H19C	0.9600
C9—C10	1.564 (5)	O20—C20	1.199 (6)
C9—H9	0.9800	C20—C21	1.524 (7)
C10—C19	1.537 (6)	O21—C21	1.404 (6)
O11—C11	1.255 (6)	O21—H21	0.8200
O11—H11	0.8200	C21—H21A	0.9700
C11—C12	1.520 (6)	C21—H21B	0.9700
C11—H11A	0.9800
C2—C1—C10	114.5 (4)	C11—C12—H12A	109.8
C2—C1—H1A	108.6	C13—C12—H12A	109.8
C10—C1—H1A	108.6	C11—C12—H12B	109.8
C2—C1—H1B	108.6	C13—C12—H12B	109.8
C10—C1—H1B	108.6	H12A—C12—H12B	108.3
H1A—C1—H1B	107.6	C12—C13—C18	109.8 (4)
C3—C2—C1	109.1 (4)	C12—C13—C14	109.0 (3)
C3—C2—H2A	109.9	C18—C13—C14	112.1 (4)
C1—C2—H2A	109.9	C12—C13—C17	116.2 (4)
C3—C2—H2B	109.9	C18—C13—C17	109.0 (4)
C1—C2—H2B	109.9	C14—C13—C17	100.6 (3)
H2A—C2—H2B	108.3	C8—C14—C13	114.4 (3)
O3—C3—C4	121.2 (5)	C8—C14—C15	119.3 (4)
O3—C3—C2	122.7 (5)	C13—C14—C15	103.6 (3)
C4—C3—C2	116.1 (4)	C8—C14—H14	106.2
C5—C4—C3	123.6 (5)	C13—C14—H14	106.2
C5—C4—H4	118.2	C15—C14—H14	106.2
C3—C4—H4	118.2	C14—C15—C16	104.4 (4)
C4—C5—C6	121.6 (4)	C14—C15—H15A	110.9
C4—C5—C10	122.7 (4)	C16—C15—H15A	110.9
C6—C5—C10	115.7 (4)	C14—C15—H15B	110.9
C5—C6—C7	111.6 (4)	C16—C15—H15B	110.9
C5—C6—H6A	109.3	H15A—C15—H15B	108.9
C7—C6—H6A	109.3	C15—C16—C17	106.8 (4)
C5—C6—H6B	109.3	C15—C16—H16A	110.4
C7—C6—H6B	109.3	C17—C16—H16A	110.4
H6A—C6—H6B	108.0	C15—C16—H16B	110.4
C8—C7—C6	113.2 (4)	C17—C16—H16B	110.4
C8—C7—H7A	108.9	H16A—C16—H16B	108.6
C6—C7—H7A	108.9	C17—O17—H17	109.5
C8—C7—H7B	108.9	O17—C17—C20	109.1 (4)
C6—C7—H7B	108.9	O17—C17—C16	111.7 (4)
H7A—C7—H7B	107.8	C20—C17—C16	113.1 (4)
C7—C8—C14	110.7 (4)	O17—C17—C13	106.8 (3)
C7—C8—C9	109.2 (3)	C20—C17—C13	112.9 (3)
C14—C8—C9	108.6 (3)	C16—C17—C13	102.9 (3)
C7—C8—H8	109.5	C13—C18—H18A	109.5
C14—C8—H8	109.5	C13—C18—H18B	109.5
C9—C8—H8	109.5	H18A—C18—H18B	109.5
C11—C9—C8	110.6 (4)	C13—C18—H18C	109.5
C11—C9—C10	115.1 (4)	H18A—C18—H18C	109.5
C8—C9—C10	115.1 (3)	H18B—C18—H18C	109.5
C11—C9—H9	104.9	C10—C19—H19A	109.5
C8—C9—H9	104.9	C10—C19—H19B	109.5
C10—C9—H9	104.9	H19A—C19—H19B	109.5
C1—C10—C5	109.9 (4)	C10—C19—H19C	109.5
C1—C10—C19	111.8 (4)	H19A—C19—H19C	109.5
C5—C10—C19	107.5 (4)	H19B—C19—H19C	109.5
C1—C10—C9	107.7 (3)	O20—C20—C21	119.5 (5)
C5—C10—C9	105.9 (3)	O20—C20—C17	123.3 (5)
C19—C10—C9	113.8 (4)	C21—C20—C17	117.1 (4)
C11—O11—H11	109.5	C21—O21—H21	109.5
O11—C11—C12	119.5 (4)	O21—C21—C20	113.2 (5)
O11—C11—C9	121.5 (4)	O21—C21—H21A	108.9
C12—C11—C9	115.2 (4)	C20—C21—H21A	108.9
O11—C11—H11A	96.5	O21—C21—H21B	108.9
C12—C11—H11A	96.5	C20—C21—H21B	108.9
C9—C11—H11A	96.5	H21A—C21—H21B	107.8
C11—C12—C13	109.2 (4)

(C_KL3)

Crystal data

C21H29.27O5	Dx = 1.296 Mg m^−3
Mr = 361.71	Mo Kα radiation, λ = 0.71073 Å
Orthorhombic, P212121	Cell parameters from 52 reflections
a = 7.7308 (7) Å	θ = 2–20°
b = 10.1237 (9) Å	µ = 0.09 mm^−1
c = 23.694 (2) Å	T = 296 K
V = 1854.4 (3) Å^3	Prism, colourles
Z = 4	0.1 × 0.05 × 0.05 mm
F(000) = 781

Data collection

Bruker d8 quest diffractometer	Rint = 0.214
Absorption correction: multi-scan sadabs	θmax = 30.5°, θmin = 2.7°
Tmin = 0.633, Tmax = 0.746	h = −10→11
30635 measured reflections	k = −11→14
5649 independent reflections	l = −33→33
1824 reflections with I > 2σ(I)

Refinement

Refinement on F^2	H-atom parameters constrained
Least-squares matrix: full	w = 1/[σ^2(Fo^2) + (0.0625P)^2] where P = (Fo^2 + 2Fc^2)/3
R[F^2 > 2σ(F^2)] = 0.072	(Δ/σ)max < 0.001
wR(F^2) = 0.191	Δρmax = 0.24 e Å^−3
S = 0.97	Δρmin = −0.21 e Å^−3
5649 reflections	Extinction correction: SHELXL-2014/7 (Sheldrick 2014, Fc^*=kFc[1+0.001xFc^2λ^3/sin(2θ)]^-1/4
242 parameters	Extinction coefficient: 0.012 (3)
0 restraints	Absolute structure: Flack x determined using 519 quotients [(I+)-(I-)]/[(I+)+(I-)] (Parsons, Flack and Wagner, Acta Cryst. B69 (2013) 249-259).
Hydrogen site location: inferred from neighbouring sites	Absolute structure parameter: −3.3 (10)

Special details

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Ų)

	x	y	z	Uiso*/Ueq	Occ. (<1)
C1	0.0404 (7)	0.3216 (8)	0.8654 (2)	0.064 (2)
H1A	−0.0605	0.3726	0.8546	0.076*
H1B	0.0349	0.2378	0.8456	0.076*
C2	0.0337 (8)	0.2954 (7)	0.9292 (2)	0.0629 (19)
H2A	0.0280	0.3787	0.9494	0.075*
H2B	−0.0691	0.2448	0.9383	0.075*
O3	0.1847 (6)	0.1291 (5)	0.9818 (2)	0.0867 (16)
C3	0.1903 (9)	0.2211 (7)	0.9470 (3)	0.0584 (17)
C4	0.3531 (7)	0.2615 (6)	0.9219 (2)	0.0471 (15)
H4	0.4554	0.2284	0.9369	0.057*
C5	0.3624 (7)	0.3449 (6)	0.8778 (2)	0.0405 (14)
C6	0.5343 (7)	0.3946 (6)	0.8565 (2)	0.0523 (17)
H6A	0.6268	0.3518	0.8773	0.063*
H6B	0.5425	0.4889	0.8631	0.063*
C7	0.5574 (7)	0.3671 (6)	0.7932 (2)	0.0507 (16)
H7A	0.6631	0.4092	0.7804	0.061*
H7B	0.5701	0.2727	0.7876	0.061*
C8	0.4065 (6)	0.4166 (6)	0.7573 (2)	0.0395 (14)
H8	0.4056	0.5134	0.7574	0.047*
C9	0.2344 (6)	0.3650 (5)	0.7821 (2)	0.0387 (14)
H9	0.2458	0.2686	0.7807	0.046*
C10	0.2046 (7)	0.3964 (5)	0.8461 (2)	0.0410 (14)
O11	−0.0141 (6)	0.4951 (6)	0.7532 (2)	0.0858 (16)
H11	−0.0537	0.5230	0.7234	0.103*	0.63 (6)
C11	0.0840 (7)	0.3949 (8)	0.7433 (2)	0.0567 (17)
H11A	0.0053	0.3251	0.7559	0.068*	0.63 (6)
C12	0.1055 (6)	0.3506 (7)	0.6825 (2)	0.0500 (17)
H12A	0.0075	0.3804	0.6603	0.060*
H12B	0.1091	0.2549	0.6809	0.060*
C13	0.2730 (6)	0.4075 (5)	0.6577 (2)	0.0356 (13)
C14	0.4241 (6)	0.3675 (6)	0.6966 (2)	0.0397 (14)
H14	0.4229	0.2708	0.6985	0.048*
C15	0.5849 (7)	0.4052 (7)	0.6626 (2)	0.0577 (17)
H15A	0.6833	0.3513	0.6734	0.069*
H15B	0.6140	0.4975	0.6681	0.069*
C16	0.5322 (7)	0.3782 (6)	0.6003 (2)	0.0512 (15)
H16A	0.5551	0.4553	0.5772	0.061*
H16B	0.5971	0.3042	0.5853	0.061*
O17	0.3042 (5)	0.2070 (3)	0.60370 (17)	0.0531 (11)
H17	0.3489	0.1703	0.5765	0.064*
C17	0.3358 (7)	0.3465 (5)	0.6006 (2)	0.0401 (13)
C18	0.2571 (8)	0.5566 (5)	0.6517 (2)	0.0577 (18)
H18A	0.2360	0.5951	0.6881	0.087*
H18B	0.1628	0.5772	0.6269	0.087*
H18C	0.3626	0.5917	0.6364	0.087*
C19	0.1886 (9)	0.5440 (6)	0.8590 (3)	0.069 (2)
H19A	0.2005	0.5581	0.8989	0.104*
H19B	0.0774	0.5752	0.8468	0.104*
H19C	0.2778	0.5914	0.8394	0.104*
O20	0.2855 (6)	0.5014 (5)	0.52516 (19)	0.0790 (14)
C20	0.2402 (8)	0.4035 (6)	0.5497 (2)	0.0482 (15)
O21	−0.0112 (7)	0.3977 (4)	0.48676 (19)	0.0739 (14)
H21	−0.0249	0.4761	0.4943	0.089*
C21	0.0738 (9)	0.3343 (7)	0.5322 (3)	0.069 (2)
H21A	0.1004	0.2442	0.5214	0.082*
H21B	−0.0038	0.3310	0.5643	0.082*

Atomic displacement parameters (Ų)

	U^11	U^22	U^33	U^12	U^13	U^23
C1	0.040 (3)	0.106 (6)	0.045 (4)	−0.014 (4)	0.008 (3)	−0.004 (4)
C2	0.053 (4)	0.090 (5)	0.045 (4)	−0.017 (4)	0.007 (3)	−0.001 (4)
O3	0.102 (4)	0.079 (4)	0.078 (3)	−0.023 (3)	0.008 (3)	0.021 (3)
C3	0.070 (5)	0.061 (5)	0.044 (4)	−0.016 (4)	0.002 (4)	−0.007 (4)
C4	0.050 (4)	0.048 (4)	0.043 (4)	−0.001 (3)	−0.002 (3)	−0.003 (3)
C5	0.042 (3)	0.039 (3)	0.041 (3)	0.000 (3)	−0.002 (3)	−0.005 (3)
C6	0.040 (3)	0.065 (4)	0.051 (4)	−0.005 (3)	−0.004 (3)	0.004 (3)
C7	0.030 (3)	0.072 (5)	0.050 (4)	−0.004 (3)	−0.001 (3)	0.006 (3)
C8	0.033 (3)	0.041 (3)	0.045 (3)	−0.004 (3)	−0.003 (3)	−0.002 (3)
C9	0.033 (3)	0.042 (4)	0.041 (3)	0.000 (3)	−0.001 (2)	−0.001 (3)
C10	0.038 (3)	0.047 (4)	0.038 (3)	−0.001 (3)	0.000 (3)	−0.007 (3)
O11	0.071 (3)	0.126 (4)	0.061 (3)	0.052 (3)	−0.017 (2)	−0.017 (3)
C11	0.040 (3)	0.089 (5)	0.041 (4)	0.009 (4)	0.001 (3)	−0.006 (4)
C12	0.036 (3)	0.071 (5)	0.043 (4)	−0.003 (3)	−0.003 (3)	−0.006 (3)
C13	0.034 (3)	0.033 (3)	0.040 (3)	0.002 (3)	−0.001 (3)	−0.001 (3)
C14	0.032 (3)	0.043 (4)	0.044 (3)	−0.006 (3)	0.002 (3)	0.003 (3)
C15	0.042 (3)	0.077 (5)	0.055 (4)	−0.005 (3)	0.002 (3)	0.003 (4)
C16	0.049 (3)	0.051 (4)	0.053 (4)	0.002 (3)	0.010 (3)	0.003 (3)
O17	0.074 (3)	0.035 (2)	0.049 (3)	0.001 (2)	0.009 (2)	−0.0039 (19)
C17	0.050 (3)	0.027 (3)	0.044 (3)	−0.001 (3)	0.004 (3)	−0.001 (3)
C18	0.073 (4)	0.044 (4)	0.057 (4)	0.013 (3)	−0.002 (3)	0.002 (3)
C19	0.080 (5)	0.061 (5)	0.066 (5)	0.026 (4)	−0.019 (4)	−0.012 (4)
O20	0.091 (3)	0.075 (3)	0.072 (3)	−0.016 (3)	−0.014 (3)	0.029 (3)
C20	0.058 (4)	0.049 (4)	0.038 (3)	−0.001 (4)	−0.004 (3)	0.001 (3)
O21	0.098 (3)	0.057 (3)	0.067 (3)	0.014 (3)	−0.033 (3)	−0.018 (3)
C21	0.076 (5)	0.078 (5)	0.052 (4)	−0.005 (4)	−0.017 (4)	−0.004 (4)

Geometric parameters (Å, º)

C1—C2	1.537 (7)	C12—C13	1.534 (7)
C1—C10	1.546 (8)	C12—H12A	0.9700
C1—H1A	0.9700	C12—H12B	0.9700
C1—H1B	0.9700	C13—C18	1.522 (7)
C2—C3	1.486 (9)	C13—C14	1.542 (7)
C2—H2A	0.9700	C13—C17	1.565 (7)
C2—H2B	0.9700	C14—C15	1.529 (7)
O3—C3	1.244 (7)	C14—H14	0.9800
C3—C4	1.451 (8)	C15—C16	1.556 (7)
C4—C5	1.345 (7)	C15—H15A	0.9700
C4—H4	0.9300	C15—H15B	0.9700
C5—C6	1.509 (7)	C16—C17	1.552 (7)
C5—C10	1.524 (7)	C16—H16A	0.9700
C6—C7	1.534 (7)	C16—H16B	0.9700
C6—H6A	0.9700	O17—C17	1.435 (6)
C6—H6B	0.9700	O17—H17	0.8200
C7—C8	1.530 (7)	C17—C20	1.528 (8)
C7—H7A	0.9700	C18—H18A	0.9600
C7—H7B	0.9700	C18—H18B	0.9600
C8—C14	1.527 (7)	C18—H18C	0.9600
C8—C9	1.545 (7)	C19—H19A	0.9600
C8—H8	0.9800	C19—H19B	0.9600
C9—C11	1.514 (7)	C19—H19C	0.9600
C9—C10	1.567 (7)	O20—C20	1.200 (7)
C9—H9	0.9800	C20—C21	1.522 (8)
C10—C19	1.531 (7)	O21—C21	1.415 (7)
O11—C11	1.288 (7)	O21—H21	0.8200
O11—H11	0.8200	C21—H21A	0.9700
C11—C12	1.517 (7)	C21—H21B	0.9700
C11—H11A	0.9800
C2—C1—C10	113.7 (5)	C11—C12—H12A	109.6
C2—C1—H1A	108.8	C13—C12—H12A	109.6
C10—C1—H1A	108.8	C11—C12—H12B	109.6
C2—C1—H1B	108.8	C13—C12—H12B	109.6
C10—C1—H1B	108.8	H12A—C12—H12B	108.1
H1A—C1—H1B	107.7	C18—C13—C12	109.9 (5)
C3—C2—C1	109.8 (5)	C18—C13—C14	112.1 (5)
C3—C2—H2A	109.7	C12—C13—C14	108.2 (4)
C1—C2—H2A	109.7	C18—C13—C17	109.7 (4)
C3—C2—H2B	109.7	C12—C13—C17	116.4 (4)
C1—C2—H2B	109.7	C14—C13—C17	100.3 (4)
H2A—C2—H2B	108.2	C8—C14—C15	119.1 (4)
O3—C3—C4	120.9 (7)	C8—C14—C13	114.2 (4)
O3—C3—C2	122.6 (6)	C15—C14—C13	103.6 (4)
C4—C3—C2	116.6 (6)	C8—C14—H14	106.3
C5—C4—C3	122.8 (6)	C15—C14—H14	106.3
C5—C4—H4	118.6	C13—C14—H14	106.3
C3—C4—H4	118.6	C14—C15—C16	104.0 (4)
C4—C5—C6	121.1 (5)	C14—C15—H15A	111.0
C4—C5—C10	123.7 (5)	C16—C15—H15A	111.0
C6—C5—C10	115.2 (5)	C14—C15—H15B	111.0
C5—C6—C7	111.7 (4)	C16—C15—H15B	111.0
C5—C6—H6A	109.3	H15A—C15—H15B	109.0
C7—C6—H6A	109.3	C17—C16—C15	106.8 (5)
C5—C6—H6B	109.3	C17—C16—H16A	110.4
C7—C6—H6B	109.3	C15—C16—H16A	110.4
H6A—C6—H6B	107.9	C17—C16—H16B	110.4
C8—C7—C6	113.3 (4)	C15—C16—H16B	110.4
C8—C7—H7A	108.9	H16A—C16—H16B	108.6
C6—C7—H7A	108.9	C17—O17—H17	109.5
C8—C7—H7B	108.9	O17—C17—C20	109.3 (5)
C6—C7—H7B	108.9	O17—C17—C16	111.8 (4)
H7A—C7—H7B	107.7	C20—C17—C16	113.1 (5)
C14—C8—C7	110.5 (4)	O17—C17—C13	106.9 (4)
C14—C8—C9	109.0 (4)	C20—C17—C13	112.6 (4)
C7—C8—C9	109.5 (4)	C16—C17—C13	103.0 (4)
C14—C8—H8	109.3	C13—C18—H18A	109.5
C7—C8—H8	109.3	C13—C18—H18B	109.5
C9—C8—H8	109.3	H18A—C18—H18B	109.5
C11—C9—C8	111.2 (4)	C13—C18—H18C	109.5
C11—C9—C10	115.8 (4)	H18A—C18—H18C	109.5
C8—C9—C10	115.3 (4)	H18B—C18—H18C	109.5
C11—C9—H9	104.3	C10—C19—H19A	109.5
C8—C9—H9	104.3	C10—C19—H19B	109.5
C10—C9—H9	104.3	H19A—C19—H19B	109.5
C5—C10—C19	107.4 (5)	C10—C19—H19C	109.5
C5—C10—C1	110.1 (4)	H19A—C19—H19C	109.5
C19—C10—C1	110.7 (5)	H19B—C19—H19C	109.5
C5—C10—C9	106.8 (4)	O20—C20—C21	119.6 (6)
C19—C10—C9	113.8 (4)	O20—C20—C17	123.6 (5)
C1—C10—C9	107.9 (4)	C21—C20—C17	116.7 (5)
C11—O11—H11	109.5	C21—O21—H21	109.5
O11—C11—C9	119.9 (5)	O21—C21—C20	113.0 (6)
O11—C11—C12	118.1 (5)	O21—C21—H21A	109.0
C9—C11—C12	115.7 (5)	C20—C21—H21A	109.0
O11—C11—H11A	98.4	O21—C21—H21B	109.0
C9—C11—H11A	98.4	C20—C21—H21B	109.0
C12—C11—H11A	98.4	H21A—C21—H21B	107.8
C11—C12—C13	110.2 (5)

(KL5)

Crystal data

C21H29.48O5	Dx = 1.306 Mg m^−3
Mr = 361.92	Mo Kα radiation, λ = 0.71073 Å
Orthorhombic, P212121	Cell parameters from 72 reflections
a = 7.6953 (9) Å	θ = 2–20°
b = 10.1268 (11) Å	µ = 0.09 mm^−1
c = 23.619 (3) Å	T = 296 K
V = 1840.6 (4) Å^3	Prism, colourless
Z = 4	0.1 × 0.05 × 0.05 mm
F(000) = 782

Data collection

Bruker d8 quest diffractometer	Rint = 0.061
Absorption correction: multi-scan sadabs	θmax = 30.5°, θmin = 2.7°
Tmin = 0.617, Tmax = 0.746	h = −10→10
15740 measured reflections	k = −14→8
5534 independent reflections	l = −33→32
4255 reflections with I > 2σ(I)

Refinement

Refinement on F^2	Hydrogen site location: inferred from neighbouring sites
Least-squares matrix: full	H-atom parameters constrained
R[F^2 > 2σ(F^2)] = 0.104	w = 1/[σ^2(Fo^2) + (0.197P)^2 + 1.1973P] where P = (Fo^2 + 2Fc^2)/3
wR(F^2) = 0.315	(Δ/σ)max < 0.001
S = 1.05	Δρmax = 0.42 e Å^−3
5534 reflections	Δρmin = −0.34 e Å^−3
241 parameters	Absolute structure: Flack x determined using 1236 quotients [(I+)-(I-)]/[(I+)+(I-)] (Parsons, Flack and Wagner, Acta Cryst. B69 (2013) 249-259).
0 restraints	Absolute structure parameter: −4.7 (10)

Special details

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Ų)

	x	y	z	Uiso*/Ueq	Occ. (<1)
C1	0.0404 (7)	0.3178 (9)	0.8653 (2)	0.0502 (17)
H1A	−0.0624	0.3661	0.8536	0.060*
H1B	0.0393	0.2332	0.8461	0.060*
C2	0.0318 (8)	0.2943 (8)	0.9291 (2)	0.0483 (16)
H2A	0.0277	0.3782	0.9489	0.058*
H2B	−0.0726	0.2451	0.9384	0.058*
O3	0.1841 (9)	0.1291 (6)	0.9817 (2)	0.0694 (16)
C3	0.1869 (8)	0.2191 (6)	0.9471 (2)	0.0421 (13)
C4	0.3525 (8)	0.2621 (6)	0.9220 (2)	0.0354 (11)
H4	0.4553	0.2305	0.9377	0.042*
C5	0.3627 (6)	0.3437 (5)	0.87814 (19)	0.0268 (9)
C6	0.5348 (6)	0.3920 (6)	0.8570 (2)	0.0351 (11)
H6A	0.6269	0.3475	0.8775	0.042*
H6B	0.5446	0.4858	0.8645	0.042*
C7	0.5588 (6)	0.3680 (7)	0.7939 (2)	0.0380 (12)
H7A	0.5738	0.2741	0.7875	0.046*
H7B	0.6640	0.4121	0.7815	0.046*
C8	0.4055 (6)	0.4174 (5)	0.75786 (19)	0.0256 (8)
H8	0.4036	0.5142	0.7579	0.031*
C9	0.2336 (6)	0.3643 (5)	0.78222 (18)	0.0243 (8)
H9	0.2465	0.2681	0.7808	0.029*
C10	0.2030 (6)	0.3955 (5)	0.84664 (18)	0.0281 (9)
O11	−0.0063 (8)	0.5034 (7)	0.7515 (2)	0.0660 (17)
H11	−0.1004	0.4996	0.7353	0.079*	0.74 (12)
C11	0.0791 (7)	0.3930 (8)	0.7433 (2)	0.0450 (15)
H11A	−0.0055	0.3277	0.7566	0.054*	0.74 (12)
C12	0.1048 (6)	0.3498 (7)	0.6823 (2)	0.0378 (12)
H12A	0.0075	0.3798	0.6595	0.045*
H12B	0.1083	0.2541	0.6804	0.045*
C13	0.2742 (6)	0.4065 (4)	0.65824 (18)	0.0241 (8)
C14	0.4251 (6)	0.3671 (5)	0.69718 (19)	0.0246 (8)
H14	0.4246	0.2704	0.6992	0.029*
C15	0.5861 (7)	0.4059 (8)	0.6634 (2)	0.0447 (14)
H15A	0.6857	0.3533	0.6746	0.054*
H15B	0.6133	0.4986	0.6686	0.054*
C16	0.5344 (7)	0.3771 (6)	0.6009 (2)	0.0379 (11)
H16A	0.5582	0.4534	0.5773	0.046*
H16B	0.5998	0.3025	0.5864	0.046*
O17	0.3064 (6)	0.2078 (4)	0.60384 (16)	0.0394 (9)
H17	0.3585	0.1706	0.5781	0.047*
C17	0.3377 (7)	0.3458 (4)	0.60094 (19)	0.0267 (9)
C18	0.2585 (10)	0.5559 (5)	0.6511 (3)	0.0423 (13)
H18A	0.2593	0.5974	0.6876	0.064*
H18B	0.1518	0.5763	0.6320	0.064*
H18C	0.3547	0.5878	0.6291	0.064*
C19	0.1854 (10)	0.5419 (6)	0.8596 (3)	0.0501 (16)
H19A	0.1906	0.5554	0.8997	0.075*
H19B	0.0761	0.5735	0.8454	0.075*
H19C	0.2784	0.5893	0.8416	0.075*
O20	0.2877 (8)	0.5018 (6)	0.5256 (2)	0.0640 (16)
C20	0.2414 (7)	0.4027 (6)	0.5499 (2)	0.0343 (10)
O21	−0.0093 (8)	0.3973 (5)	0.4870 (2)	0.0606 (15)
H21	−0.0342	0.4727	0.4967	0.073*
C21	0.0751 (10)	0.3321 (8)	0.5320 (3)	0.0522 (16)
H21A	0.1030	0.2426	0.5205	0.063*
H21B	−0.0031	0.3271	0.5641	0.063*

Atomic displacement parameters (Ų)

	U^11	U^22	U^33	U^12	U^13	U^23
C1	0.027 (3)	0.098 (5)	0.025 (2)	−0.014 (3)	0.0026 (19)	−0.011 (3)
C2	0.036 (3)	0.086 (5)	0.023 (2)	−0.016 (3)	0.0055 (19)	−0.005 (3)
O3	0.085 (4)	0.073 (3)	0.050 (3)	−0.017 (3)	0.008 (3)	0.018 (3)
C3	0.047 (3)	0.054 (3)	0.025 (2)	−0.014 (3)	0.005 (2)	−0.003 (2)
C4	0.037 (3)	0.044 (3)	0.026 (2)	−0.002 (2)	−0.0015 (19)	0.000 (2)
C5	0.0242 (19)	0.033 (2)	0.0235 (19)	−0.0018 (17)	−0.0023 (15)	−0.0056 (16)
C6	0.025 (2)	0.049 (3)	0.032 (2)	−0.008 (2)	−0.0071 (18)	0.008 (2)
C7	0.0187 (19)	0.065 (3)	0.030 (2)	−0.003 (2)	0.0007 (17)	0.007 (2)
C8	0.0229 (19)	0.0295 (19)	0.0245 (19)	−0.0066 (16)	−0.0023 (15)	0.0022 (16)
C9	0.0205 (18)	0.0301 (19)	0.0223 (18)	−0.0015 (16)	−0.0006 (14)	−0.0032 (15)
C10	0.027 (2)	0.037 (2)	0.0202 (18)	0.0024 (18)	0.0004 (16)	−0.0043 (17)
O11	0.053 (3)	0.101 (4)	0.043 (2)	0.044 (3)	−0.014 (2)	−0.018 (3)
C11	0.022 (2)	0.088 (5)	0.025 (2)	0.011 (3)	0.0001 (18)	−0.002 (3)
C12	0.023 (2)	0.066 (4)	0.024 (2)	−0.008 (2)	−0.0019 (17)	−0.004 (2)
C13	0.025 (2)	0.0255 (18)	0.0217 (18)	0.0002 (16)	0.0018 (15)	0.0007 (15)
C14	0.0178 (17)	0.0297 (19)	0.0262 (19)	−0.0011 (15)	0.0000 (15)	0.0002 (16)
C15	0.028 (2)	0.075 (4)	0.032 (2)	−0.012 (3)	0.0049 (19)	0.005 (3)
C16	0.033 (2)	0.049 (3)	0.032 (2)	0.000 (2)	0.010 (2)	0.002 (2)
O17	0.060 (3)	0.0277 (16)	0.0303 (17)	−0.0001 (16)	0.0079 (17)	−0.0060 (14)
C17	0.032 (2)	0.0235 (18)	0.0245 (19)	−0.0029 (17)	0.0042 (17)	−0.0006 (15)
C18	0.061 (4)	0.033 (2)	0.033 (2)	0.007 (3)	−0.001 (2)	0.001 (2)
C19	0.066 (4)	0.044 (3)	0.040 (3)	0.026 (3)	−0.016 (3)	−0.016 (2)
O20	0.074 (4)	0.071 (3)	0.047 (3)	−0.020 (3)	−0.012 (2)	0.031 (3)
C20	0.039 (3)	0.042 (3)	0.0216 (19)	0.003 (2)	0.0017 (18)	−0.0004 (19)
O21	0.078 (4)	0.058 (3)	0.046 (2)	0.014 (3)	−0.032 (3)	−0.021 (2)
C21	0.052 (4)	0.071 (4)	0.034 (3)	−0.009 (3)	−0.012 (3)	−0.008 (3)

Geometric parameters (Å, º)

C1—C2	1.527 (8)	C12—C13	1.533 (7)
C1—C10	1.542 (8)	C12—H12A	0.9700
C1—H1A	0.9700	C12—H12B	0.9700
C1—H1B	0.9700	C13—C18	1.526 (7)
C2—C3	1.478 (10)	C13—C14	1.535 (6)
C2—H2A	0.9700	C13—C17	1.565 (6)
C2—H2B	0.9700	C14—C15	1.525 (7)
O3—C3	1.225 (8)	C14—H14	0.9800
C3—C4	1.471 (8)	C15—C16	1.556 (8)
C4—C5	1.328 (7)	C15—H15A	0.9700
C4—H4	0.9300	C15—H15B	0.9700
C5—C6	1.498 (7)	C16—C17	1.547 (7)
C5—C10	1.529 (7)	C16—H16A	0.9700
C6—C7	1.521 (7)	C16—H16B	0.9700
C6—H6A	0.9700	O17—C17	1.419 (6)
C6—H6B	0.9700	O17—H17	0.8200
C7—C8	1.538 (7)	C17—C20	1.528 (7)
C7—H7A	0.9700	C18—H18A	0.9600
C7—H7B	0.9700	C18—H18B	0.9600
C8—C14	1.529 (6)	C18—H18C	0.9600
C8—C9	1.540 (6)	C19—H19A	0.9600
C8—H8	0.9800	C19—H19B	0.9600
C9—C11	1.530 (7)	C19—H19C	0.9600
C9—C10	1.572 (6)	O20—C20	1.209 (7)
C9—H9	0.9800	C20—C21	1.526 (9)
C10—C19	1.520 (8)	O21—C21	1.410 (8)
O11—C11	1.311 (9)	O21—H21	0.8200
O11—H11	0.8200	C21—H21A	0.9700
C11—C12	1.520 (7)	C21—H21B	0.9700
C11—H11A	0.9800
C2—C1—C10	113.4 (5)	C11—C12—H12A	109.5
C2—C1—H1A	108.9	C13—C12—H12A	109.5
C10—C1—H1A	108.9	C11—C12—H12B	109.5
C2—C1—H1B	108.9	C13—C12—H12B	109.5
C10—C1—H1B	108.9	H12A—C12—H12B	108.1
H1A—C1—H1B	107.7	C18—C13—C12	110.2 (5)
C3—C2—C1	109.1 (5)	C18—C13—C14	112.6 (4)
C3—C2—H2A	109.9	C12—C13—C14	108.9 (4)
C1—C2—H2A	109.9	C18—C13—C17	108.5 (4)
C3—C2—H2B	109.9	C12—C13—C17	116.0 (4)
C1—C2—H2B	109.9	C14—C13—C17	100.3 (4)
H2A—C2—H2B	108.3	C15—C14—C8	119.0 (4)
O3—C3—C4	120.3 (7)	C15—C14—C13	103.5 (4)
O3—C3—C2	124.1 (6)	C8—C14—C13	113.6 (4)
C4—C3—C2	115.6 (5)	C15—C14—H14	106.7
C5—C4—C3	123.3 (5)	C8—C14—H14	106.7
C5—C4—H4	118.3	C13—C14—H14	106.7
C3—C4—H4	118.3	C14—C15—C16	103.9 (4)
C4—C5—C6	121.1 (5)	C14—C15—H15A	111.0
C4—C5—C10	123.1 (5)	C16—C15—H15A	111.0
C6—C5—C10	115.8 (4)	C14—C15—H15B	111.0
C5—C6—C7	112.5 (4)	C16—C15—H15B	111.0
C5—C6—H6A	109.1	H15A—C15—H15B	109.0
C7—C6—H6A	109.1	C17—C16—C15	106.7 (4)
C5—C6—H6B	109.1	C17—C16—H16A	110.4
C7—C6—H6B	109.1	C15—C16—H16A	110.4
H6A—C6—H6B	107.8	C17—C16—H16B	110.4
C6—C7—C8	113.4 (4)	C15—C16—H16B	110.4
C6—C7—H7A	108.9	H16A—C16—H16B	108.6
C8—C7—H7A	108.9	C17—O17—H17	109.5
C6—C7—H7B	108.9	O17—C17—C20	109.1 (4)
C8—C7—H7B	108.9	O17—C17—C16	111.6 (4)
H7A—C7—H7B	107.7	C20—C17—C16	113.4 (4)
C14—C8—C7	109.5 (4)	O17—C17—C13	107.0 (4)
C14—C8—C9	108.6 (3)	C20—C17—C13	112.5 (4)
C7—C8—C9	109.8 (4)	C16—C17—C13	103.0 (4)
C14—C8—H8	109.6	C13—C18—H18A	109.5
C7—C8—H8	109.6	C13—C18—H18B	109.5
C9—C8—H8	109.6	H18A—C18—H18B	109.5
C11—C9—C8	112.1 (4)	C13—C18—H18C	109.5
C11—C9—C10	115.3 (4)	H18A—C18—H18C	109.5
C8—C9—C10	114.8 (4)	H18B—C18—H18C	109.5
C11—C9—H9	104.3	C10—C19—H19A	109.5
C8—C9—H9	104.3	C10—C19—H19B	109.5
C10—C9—H9	104.3	H19A—C19—H19B	109.5
C19—C10—C5	108.0 (4)	C10—C19—H19C	109.5
C19—C10—C1	111.6 (5)	H19A—C19—H19C	109.5
C5—C10—C1	109.7 (4)	H19B—C19—H19C	109.5
C19—C10—C9	113.8 (4)	O20—C20—C21	120.3 (5)
C5—C10—C9	106.4 (4)	O20—C20—C17	123.0 (5)
C1—C10—C9	107.2 (4)	C21—C20—C17	116.6 (5)
C11—O11—H11	109.5	C21—O21—H21	109.5
O11—C11—C12	116.8 (5)	O21—C21—C20	112.1 (6)
O11—C11—C9	117.5 (5)	O21—C21—H21A	109.2
C12—C11—C9	114.5 (4)	C20—C21—H21A	109.2
O11—C11—H11A	101.3	O21—C21—H21B	109.2
C12—C11—H11A	101.3	C20—C21—H21B	109.2
C9—C11—H11A	101.3	H21A—C21—H21B	107.9
C11—C12—C13	110.7 (4)

(C_KL2_HC)

Crystal data

C21H30O5	Dx = 1.242 Mg m^−3
Mr = 362.45	Cu Kα radiation, λ = 1.54178 Å
Orthorhombic, P212121	Cell parameters from 321 reflections
a = 10.1439 (14) Å	θ = 2–20°
b = 12.4255 (16) Å	µ = 0.71 mm^−1
c = 30.496 (5) Å	T = 300 K
V = 3843.8 (10) Å^3	Prism, colourless
Z = 8	0.2 × 0.1 × 0.1 mm
F(000) = 1544

Data collection

Bruker d8 quest diffractometer	Rint = 0.909
Absorption correction: multi-scan sadabs	θmax = 62.8°, θmin = 2.9°
Tmin = 0.493, Tmax = 0.752	h = −11→10
22035 measured reflections	k = −14→14
6127 independent reflections	l = −35→20
931 reflections with I > 2σ(I)

Refinement

Refinement on F^2	H atoms treated by a mixture of independent and constrained refinement
Least-squares matrix: full	w = 1/[σ^2(Fo^2) + (0.1385P)^2] where P = (Fo^2 + 2Fc^2)/3
R[F^2 > 2σ(F^2)] = 0.098	(Δ/σ)max = 2.522
wR(F^2) = 0.392	Δρmax = 0.34 e Å^−3
S = 0.83	Δρmin = −0.29 e Å^−3
6127 reflections	Extinction correction: SHELXL-2014/7 (Sheldrick 2014, Fc^*=kFc[1+0.001xFc^2λ^3/sin(2θ)]^-1/4
486 parameters	Extinction coefficient: 0.0005 (2)
0 restraints	Absolute structure: Flack x determined using 212 quotients [(I+)-(I-)]/[(I+)+(I-)] (Parsons, Flack and Wagner, Acta Cryst. B69 (2013) 249-259).
Hydrogen site location: inferred from neighbouring sites	Absolute structure parameter: 0.7 (7)

Special details

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Ų)

	x	y	z	Uiso*/Ueq
C1A	0.324 (3)	0.301 (3)	0.7637 (11)	0.128 (12)
H1A1	0.4113	0.3296	0.7587	0.153*
H1A2	0.2688	0.3225	0.7392	0.153*
C2A	0.332 (3)	0.176 (3)	0.7643 (11)	0.110 (11)
H2A1	0.2441	0.1453	0.7644	0.131*
H2A2	0.3777	0.1505	0.7384	0.131*
O3A	0.4594 (19)	0.0529 (18)	0.8060 (8)	0.131 (9)
C3A	0.402 (3)	0.142 (3)	0.8029 (17)	0.125 (13)
C4A	0.401 (3)	0.206 (3)	0.8431 (12)	0.121 (13)
H4A	0.4481	0.1828	0.8674	0.146*
C5A	0.334 (3)	0.298 (4)	0.8452 (13)	0.096 (11)
C6A	0.313 (3)	0.353 (3)	0.8867 (14)	0.145 (14)
H6A1	0.3772	0.3262	0.9078	0.174*
H6A2	0.2262	0.3344	0.8976	0.174*
C7A	0.325 (3)	0.477 (3)	0.8840 (10)	0.127 (12)
H7A1	0.2947	0.5070	0.9115	0.152*
H7A2	0.4176	0.4951	0.8810	0.152*
C8A	0.252 (3)	0.529 (3)	0.8482 (12)	0.103 (10)
H8A	0.1572	0.5210	0.8527	0.124*
C9A	0.294 (3)	0.476 (3)	0.8052 (10)	0.087 (9)
H9A	0.3900	0.4826	0.8052	0.105*
C10A	0.269 (3)	0.350 (3)	0.8049 (13)	0.096 (10)
O11A	0.1128 (17)	0.5040 (19)	0.7540 (7)	0.111 (7)
H11A	0.1001	0.4969	0.7276	0.08 (11)*
C11A	0.251 (3)	0.534 (3)	0.7616 (9)	0.102 (10)
H1	0.3036	0.5050	0.7375	0.122*
C12A	0.272 (3)	0.658 (3)	0.7632 (9)	0.103 (10)
H12A	0.3654	0.6738	0.7597	0.123*
H12B	0.2255	0.6917	0.7390	0.123*
C13A	0.225 (3)	0.706 (3)	0.8057 (12)	0.097 (10)
C14A	0.288 (3)	0.650 (2)	0.8428 (11)	0.090 (9)
H14A	0.3824	0.6517	0.8368	0.108*
C15A	0.266 (3)	0.725 (3)	0.8842 (10)	0.132 (13)
H15A	0.3383	0.7177	0.9050	0.158*
H15B	0.1838	0.7087	0.8989	0.158*
C16A	0.264 (3)	0.841 (3)	0.8625 (12)	0.109 (11)
H16A	0.1848	0.8796	0.8712	0.131*
H16B	0.3400	0.8825	0.8718	0.131*
O17A	0.4081 (17)	0.8334 (18)	0.8015 (7)	0.112 (6)
H17A	0.4151	0.8404	0.7749	0.00 (5)*
C17A	0.266 (3)	0.826 (3)	0.8134 (13)	0.113 (11)
C18A	0.074 (2)	0.711 (2)	0.8095 (7)	0.124 (12)
H18A	0.0385	0.6403	0.8132	0.186*
H18B	0.0378	0.7429	0.7833	0.186*
H18C	0.0500	0.7550	0.8343	0.186*
C19A	0.118 (2)	0.3170 (19)	0.8084 (9)	0.134 (13)
H19A	0.0811	0.3119	0.7796	0.201*
H19B	0.0717	0.3706	0.8250	0.201*
H19C	0.1108	0.2487	0.8229	0.201*
O20A	0.109 (2)	0.9659 (18)	0.8050 (8)	0.125 (9)
C20A	0.194 (4)	0.915 (3)	0.7888 (12)	0.102 (11)
O21A	0.1419 (17)	0.9895 (18)	0.7188 (7)	0.120 (7)
H21A	0.1804	1.0449	0.7118	0.00 (5)*
C21A	0.232 (3)	0.918 (3)	0.7396 (12)	0.174 (19)
H3	0.3215	0.9442	0.7362	0.209*
H21B	0.2257	0.8470	0.7269	0.209*
C1B	0.317 (3)	1.172 (3)	0.6069 (11)	0.114 (11)
H1B1	0.4048	1.1414	0.6105	0.137*
H1B2	0.2652	1.1514	0.6322	0.137*
C2B	0.329 (3)	1.303 (3)	0.6053 (12)	0.140 (15)
H2B1	0.2423	1.3351	0.6080	0.168*
H2B2	0.3830	1.3284	0.6295	0.168*
O3B	0.444 (2)	1.4225 (18)	0.5594 (9)	0.160 (12)
C3B	0.391 (3)	1.337 (4)	0.562 (2)	0.144 (18)
C4B	0.370 (4)	1.273 (3)	0.5245 (17)	0.15 (2)
H4B	0.4009	1.2961	0.4974	0.179*
C5B	0.309 (4)	1.180 (5)	0.5275 (13)	0.14 (2)
C6B	0.272 (3)	1.117 (3)	0.4871 (15)	0.150 (17)
H6B1	0.1802	1.1318	0.4808	0.180*
H6B2	0.3232	1.1461	0.4629	0.180*
C7B	0.290 (3)	0.998 (4)	0.4873 (9)	0.137 (13)
H7B1	0.3838	0.9812	0.4866	0.165*
H7B2	0.2499	0.9674	0.4614	0.165*
C8B	0.228 (3)	0.948 (2)	0.5284 (12)	0.086 (9)
H8B	0.1324	0.9581	0.5272	0.103*
C9B	0.280 (3)	1.001 (3)	0.5686 (12)	0.099 (9)
H9B	0.3753	0.9926	0.5659	0.119*
C10B	0.259 (3)	1.129 (3)	0.5685 (15)	0.093 (10)
O11B	0.1163 (19)	0.9724 (16)	0.6275 (6)	0.115 (7)
H11B	0.0646	0.9370	0.6127	2 (2)*
C11B	0.248 (4)	0.950 (3)	0.6139 (11)	0.106 (11)
H2	0.3090	0.9801	0.6356	0.128*
C12B	0.268 (3)	0.825 (3)	0.6127 (9)	0.109 (10)
H12C	0.3619	0.8097	0.6138	0.130*
H12D	0.2287	0.7941	0.6388	0.130*
C13B	0.210 (3)	0.769 (3)	0.5725 (12)	0.095 (10)
C14B	0.260 (3)	0.823 (3)	0.5317 (11)	0.120 (12)
H14B	0.3566	0.8172	0.5331	0.144*
C15B	0.219 (3)	0.756 (3)	0.4939 (11)	0.122 (11)
H15C	0.2791	0.7644	0.4694	0.146*
H15D	0.1306	0.7733	0.4846	0.146*
C16B	0.227 (3)	0.631 (3)	0.5144 (11)	0.126 (12)
H16C	0.1457	0.5924	0.5090	0.151*
H16D	0.2996	0.5913	0.5014	0.151*
O17B	0.392 (2)	0.639 (2)	0.5739 (8)	0.122 (8)
H17B	0.4330	0.6775	0.5567	0.09 (13)*
C17B	0.250 (4)	0.648 (3)	0.5646 (11)	0.105 (10)
C18B	0.058 (2)	0.779 (2)	0.5739 (8)	0.130 (12)
H18D	0.0325	0.8501	0.5652	0.196*
H18E	0.0272	0.7651	0.6031	0.196*
H18F	0.0195	0.7273	0.5542	0.196*
C19B	0.105 (2)	1.160 (2)	0.5697 (9)	0.146 (13)
H19D	0.0666	1.1327	0.5962	0.218*
H19E	0.0617	1.1286	0.5449	0.218*
H19F	0.0960	1.2367	0.5688	0.218*
O20B	0.086 (2)	0.5175 (19)	0.5811 (7)	0.144 (9)
C20B	0.184 (3)	0.569 (3)	0.5939 (15)	0.119 (13)
O21B	0.1432 (19)	0.4876 (19)	0.6605 (8)	0.136 (8)
H21C	0.1834	0.4542	0.6795	0.03 (7)*
C21B	0.230 (3)	0.562 (3)	0.6398 (12)	0.154 (16)
H4	0.3204	0.5361	0.6409	0.185*
H21D	0.2260	0.6317	0.6540	0.185*

Atomic displacement parameters (Ų)

	U^11	U^22	U^33	U^12	U^13	U^23
C1A	0.11 (3)	0.14 (4)	0.13 (4)	−0.03 (3)	0.00 (2)	0.02 (3)
C2A	0.11 (3)	0.10 (3)	0.13 (3)	0.02 (2)	0.00 (2)	0.01 (3)
O3A	0.101 (15)	0.100 (16)	0.19 (2)	0.013 (13)	−0.025 (14)	−0.022 (18)
C3A	0.09 (3)	0.11 (4)	0.17 (4)	−0.02 (3)	−0.01 (3)	0.03 (4)
C4A	0.13 (3)	0.12 (3)	0.11 (3)	0.03 (3)	−0.06 (3)	−0.04 (3)
C5A	0.07 (2)	0.13 (4)	0.09 (3)	−0.01 (2)	−0.01 (2)	0.01 (3)
C6A	0.16 (3)	0.11 (4)	0.16 (5)	0.03 (3)	−0.03 (3)	0.04 (3)
C7A	0.13 (3)	0.16 (4)	0.09 (3)	−0.04 (3)	0.00 (2)	0.00 (3)
C8A	0.12 (3)	0.10 (3)	0.09 (3)	−0.02 (2)	−0.01 (2)	0.01 (3)
C9A	0.08 (2)	0.11 (3)	0.07 (2)	0.01 (2)	−0.006 (19)	0.02 (2)
C10A	0.09 (3)	0.12 (3)	0.08 (3)	0.00 (2)	0.02 (2)	0.01 (3)
O11A	0.089 (15)	0.143 (19)	0.102 (18)	−0.005 (14)	−0.009 (11)	−0.018 (17)
C11A	0.06 (2)	0.16 (3)	0.08 (3)	0.02 (2)	0.010 (18)	0.00 (3)
C12A	0.11 (2)	0.12 (3)	0.08 (3)	−0.03 (2)	−0.01 (2)	0.00 (2)
C13A	0.08 (2)	0.12 (3)	0.10 (3)	−0.02 (2)	0.01 (2)	−0.01 (3)
C14A	0.10 (2)	0.08 (3)	0.09 (3)	−0.01 (2)	−0.04 (2)	0.02 (2)
C15A	0.11 (2)	0.17 (4)	0.12 (3)	−0.01 (3)	0.01 (2)	0.04 (3)
C16A	0.070 (19)	0.14 (3)	0.11 (3)	0.00 (2)	−0.02 (2)	−0.02 (3)
O17A	0.095 (17)	0.142 (18)	0.10 (2)	0.003 (14)	−0.008 (12)	0.015 (17)
C17A	0.07 (3)	0.14 (4)	0.12 (4)	0.02 (3)	−0.01 (2)	0.02 (3)
C18A	0.07 (2)	0.22 (3)	0.08 (2)	−0.02 (2)	0.021 (16)	0.02 (2)
C19A	0.07 (2)	0.10 (2)	0.23 (4)	0.02 (2)	0.00 (2)	0.05 (2)
O20A	0.090 (16)	0.128 (19)	0.16 (2)	0.007 (15)	0.027 (15)	−0.020 (16)
C20A	0.11 (3)	0.11 (3)	0.09 (3)	−0.02 (2)	−0.02 (3)	0.00 (3)
O21A	0.102 (14)	0.14 (2)	0.119 (18)	−0.022 (16)	−0.002 (13)	0.025 (17)
C21A	0.15 (3)	0.24 (5)	0.14 (4)	0.11 (3)	−0.05 (3)	−0.01 (3)
C1B	0.13 (3)	0.09 (3)	0.13 (4)	0.03 (2)	0.00 (2)	0.01 (2)
C2B	0.14 (3)	0.15 (4)	0.13 (4)	−0.02 (3)	0.02 (3)	−0.01 (3)
O3B	0.15 (2)	0.13 (2)	0.20 (2)	−0.038 (17)	0.044 (18)	−0.02 (2)
C3B	0.06 (3)	0.14 (5)	0.23 (6)	0.02 (3)	−0.06 (3)	−0.02 (5)
C4B	0.11 (3)	0.12 (4)	0.22 (6)	−0.07 (2)	0.02 (3)	−0.04 (3)
C5B	0.11 (3)	0.26 (7)	0.06 (3)	0.06 (4)	−0.03 (3)	−0.03 (4)
C6B	0.11 (3)	0.11 (3)	0.22 (5)	0.02 (3)	−0.01 (3)	0.08 (3)
C7B	0.10 (2)	0.24 (5)	0.08 (2)	0.00 (3)	0.02 (2)	0.03 (3)
C8B	0.064 (19)	0.08 (2)	0.11 (3)	0.004 (18)	−0.02 (2)	−0.01 (2)
C9B	0.064 (19)	0.12 (3)	0.11 (3)	0.02 (2)	0.00 (2)	−0.01 (3)
C10B	0.09 (3)	0.10 (3)	0.10 (3)	0.00 (2)	−0.02 (2)	−0.03 (3)
O11B	0.094 (13)	0.130 (17)	0.120 (16)	0.021 (14)	0.004 (13)	0.003 (13)
C11B	0.14 (3)	0.09 (3)	0.09 (3)	0.01 (3)	−0.02 (2)	−0.04 (2)
C12B	0.10 (2)	0.14 (3)	0.08 (3)	0.01 (2)	0.018 (19)	−0.01 (2)
C13B	0.10 (3)	0.10 (3)	0.09 (3)	0.01 (2)	−0.03 (2)	−0.02 (2)
C14B	0.13 (3)	0.15 (4)	0.08 (3)	0.01 (3)	0.05 (3)	−0.01 (3)
C15B	0.11 (2)	0.15 (3)	0.10 (3)	0.00 (2)	−0.01 (2)	−0.03 (3)
C16B	0.09 (2)	0.18 (4)	0.11 (3)	−0.01 (2)	0.00 (2)	0.04 (3)
O17B	0.064 (13)	0.16 (2)	0.15 (2)	0.001 (16)	0.017 (15)	−0.014 (16)
C17B	0.11 (3)	0.14 (3)	0.07 (3)	0.03 (3)	0.03 (2)	0.01 (2)
C18B	0.07 (2)	0.18 (3)	0.15 (3)	0.02 (2)	0.000 (18)	0.00 (2)
C19B	0.08 (2)	0.17 (3)	0.18 (4)	0.01 (3)	0.01 (2)	0.03 (3)
O20B	0.107 (18)	0.18 (2)	0.14 (2)	−0.006 (18)	−0.040 (16)	−0.007 (17)
C20B	0.06 (2)	0.15 (4)	0.14 (4)	0.01 (2)	0.02 (3)	0.03 (3)
O21B	0.151 (19)	0.13 (2)	0.12 (2)	0.033 (18)	−0.021 (17)	0.017 (16)
C21B	0.17 (4)	0.18 (4)	0.12 (3)	−0.02 (3)	0.01 (3)	0.08 (3)

Geometric parameters (Å, º)

C1A—C10A	1.50 (3)	C1B—C10B	1.42 (3)
C1A—C2A	1.56 (3)	C1B—C2B	1.64 (4)
C1A—H1A1	0.9700	C1B—H1B1	0.9700
C1A—H1A2	0.9700	C1B—H1B2	0.9700
C2A—C3A	1.44 (4)	C2B—C3B	1.51 (5)
C2A—H2A1	0.9700	C2B—H2B1	0.9700
C2A—H2A2	0.9700	C2B—H2B2	0.9700
O3A—C3A	1.26 (4)	O3B—C3B	1.20 (4)
C3A—C4A	1.46 (5)	C3B—C4B	1.42 (5)
C4A—C5A	1.33 (4)	C4B—C5B	1.31 (6)
C4A—H4A	0.9300	C4B—H4B	0.9300
C5A—C6A	1.45 (4)	C5B—C10B	1.49 (5)
C5A—C10A	1.54 (4)	C5B—C6B	1.50 (5)
C6A—C7A	1.55 (4)	C6B—C7B	1.49 (4)
C6A—H6A1	0.9700	C6B—H6B1	0.9700
C6A—H6A2	0.9700	C6B—H6B2	0.9700
C7A—C8A	1.47 (3)	C7B—C8B	1.53 (3)
C7A—H7A1	0.9700	C7B—H7B1	0.9700
C7A—H7A2	0.9700	C7B—H7B2	0.9700
C8A—C9A	1.53 (3)	C8B—C9B	1.48 (3)
C8A—C14A	1.55 (3)	C8B—C14B	1.60 (4)
C8A—H8A	0.9800	C8B—H8B	0.9800
C9A—C11A	1.57 (3)	C9B—C11B	1.55 (3)
C9A—C10A	1.59 (4)	C9B—C10B	1.61 (4)
C9A—H9A	0.9800	C9B—H9B	0.9800
C10A—C19A	1.58 (3)	C10B—C19B	1.60 (3)
O11A—C11A	1.47 (3)	O11B—C11B	1.43 (3)
O11A—H11A	0.8200	O11B—H11B	0.8200
C11A—C12A	1.56 (3)	C11B—C12B	1.57 (3)
C11A—H1	0.9800	C11B—H2	0.9800
C12A—C13A	1.50 (3)	C12B—C13B	1.53 (3)
C12A—H12A	0.9700	C12B—H12C	0.9700
C12A—H12B	0.9700	C12B—H12D	0.9700
C13A—C14A	1.47 (3)	C13B—C14B	1.50 (4)
C13A—C18A	1.54 (3)	C13B—C18B	1.55 (3)
C13A—C17A	1.57 (4)	C13B—C17B	1.58 (4)
C14A—C15A	1.58 (3)	C14B—C15B	1.48 (4)
C14A—H14A	0.9800	C14B—H14B	0.9800
C15A—C16A	1.59 (3)	C15B—C16B	1.67 (4)
C15A—H15A	0.9700	C15B—H15C	0.9700
C15A—H15B	0.9700	C15B—H15D	0.9700
C16A—C17A	1.51 (4)	C16B—C17B	1.56 (4)
C16A—H16A	0.9700	C16B—H16C	0.9700
C16A—H16B	0.9700	C16B—H16D	0.9700
O17A—C17A	1.49 (3)	O17B—C17B	1.47 (3)
O17A—H17A	0.8200	O17B—H17B	0.8200
C17A—C20A	1.54 (4)	C17B—C20B	1.48 (4)
C18A—H18A	0.9600	C18B—H18D	0.9600
C18A—H18B	0.9600	C18B—H18E	0.9600
C18A—H18C	0.9600	C18B—H18F	0.9600
C19A—H19A	0.9600	C19B—H19D	0.9600
C19A—H19B	0.9600	C19B—H19E	0.9600
C19A—H19C	0.9600	C19B—H19F	0.9600
O20A—C20A	1.17 (3)	O20B—C20B	1.25 (3)
C20A—C21A	1.55 (4)	C20B—C21B	1.48 (4)
O21A—C21A	1.42 (3)	O21B—C21B	1.43 (3)
O21A—H21A	0.8200	O21B—H21C	0.8200
C21A—H3	0.9700	C21B—H4	0.9700
C21A—H21B	0.9700	C21B—H21D	0.9700
C10A—C1A—C2A	114 (3)	C10B—C1B—C2B	112 (3)
C10A—C1A—H1A1	108.7	C10B—C1B—H1B1	109.1
C2A—C1A—H1A1	108.7	C2B—C1B—H1B1	109.1
C10A—C1A—H1A2	108.7	C10B—C1B—H1B2	109.1
C2A—C1A—H1A2	108.7	C2B—C1B—H1B2	109.1
H1A1—C1A—H1A2	107.6	H1B1—C1B—H1B2	107.9
C3A—C2A—C1A	109 (3)	C3B—C2B—C1B	110 (3)
C3A—C2A—H2A1	109.8	C3B—C2B—H2B1	109.8
C1A—C2A—H2A1	109.8	C1B—C2B—H2B1	109.8
C3A—C2A—H2A2	109.8	C3B—C2B—H2B2	109.8
C1A—C2A—H2A2	109.8	C1B—C2B—H2B2	109.8
H2A1—C2A—H2A2	108.3	H2B1—C2B—H2B2	108.2
O3A—C3A—C2A	123 (5)	O3B—C3B—C4B	120 (6)
O3A—C3A—C4A	115 (5)	O3B—C3B—C2B	120 (5)
C2A—C3A—C4A	122 (4)	C4B—C3B—C2B	119 (4)
C5A—C4A—C3A	121 (4)	C5B—C4B—C3B	121 (5)
C5A—C4A—H4A	119.6	C5B—C4B—H4B	119.7
C3A—C4A—H4A	119.6	C3B—C4B—H4B	119.7
C4A—C5A—C6A	121 (4)	C4B—C5B—C10B	126 (4)
C4A—C5A—C10A	122 (4)	C4B—C5B—C6B	121 (5)
C6A—C5A—C10A	116 (4)	C10B—C5B—C6B	113 (5)
C5A—C6A—C7A	114 (3)	C7B—C6B—C5B	119 (4)
C5A—C6A—H6A1	108.8	C7B—C6B—H6B1	107.6
C7A—C6A—H6A1	108.8	C5B—C6B—H6B1	107.6
C5A—C6A—H6A2	108.8	C7B—C6B—H6B2	107.6
C7A—C6A—H6A2	108.8	C5B—C6B—H6B2	107.6
H6A1—C6A—H6A2	107.6	H6B1—C6B—H6B2	107.1
C8A—C7A—C6A	116 (3)	C6B—C7B—C8B	111 (3)
C8A—C7A—H7A1	108.2	C6B—C7B—H7B1	109.5
C6A—C7A—H7A1	108.2	C8B—C7B—H7B1	109.5
C8A—C7A—H7A2	108.2	C6B—C7B—H7B2	109.5
C6A—C7A—H7A2	108.2	C8B—C7B—H7B2	109.5
H7A1—C7A—H7A2	107.4	H7B1—C7B—H7B2	108.1
C7A—C8A—C9A	108 (3)	C9B—C8B—C7B	111 (3)
C7A—C8A—C14A	113 (3)	C9B—C8B—C14B	108 (3)
C9A—C8A—C14A	105 (3)	C7B—C8B—C14B	111 (3)
C7A—C8A—H8A	110.1	C9B—C8B—H8B	109.0
C9A—C8A—H8A	110.1	C7B—C8B—H8B	109.0
C14A—C8A—H8A	110.1	C14B—C8B—H8B	109.0
C8A—C9A—C11A	117 (3)	C8B—C9B—C11B	119 (3)
C8A—C9A—C10A	113 (3)	C8B—C9B—C10B	113 (3)
C11A—C9A—C10A	114 (3)	C11B—C9B—C10B	112 (3)
C8A—C9A—H9A	103.8	C8B—C9B—H9B	103.5
C11A—C9A—H9A	103.8	C11B—C9B—H9B	103.5
C10A—C9A—H9A	103.8	C10B—C9B—H9B	103.5
C1A—C10A—C5A	110 (3)	C1B—C10B—C5B	113 (3)
C1A—C10A—C19A	108 (3)	C1B—C10B—C9B	108 (3)
C5A—C10A—C19A	105 (3)	C5B—C10B—C9B	112 (4)
C1A—C10A—C9A	110 (3)	C1B—C10B—C19B	107 (3)
C5A—C10A—C9A	110 (3)	C5B—C10B—C19B	104 (3)
C19A—C10A—C9A	114 (3)	C9B—C10B—C19B	111 (2)
C11A—O11A—H11A	109.5	C11B—O11B—H11B	109.5
O11A—C11A—C12A	113 (2)	O11B—C11B—C9B	112 (3)
O11A—C11A—C9A	106 (2)	O11B—C11B—C12B	109 (3)
C12A—C11A—C9A	113 (2)	C9B—C11B—C12B	111 (3)
O11A—C11A—H1	108.1	O11B—C11B—H2	108.4
C12A—C11A—H1	108.1	C9B—C11B—H2	108.4
C9A—C11A—H1	108.1	C12B—C11B—H2	108.4
C13A—C12A—C11A	111 (3)	C13B—C12B—C11B	115 (3)
C13A—C12A—H12A	109.3	C13B—C12B—H12C	108.6
C11A—C12A—H12A	109.3	C11B—C12B—H12C	108.6
C13A—C12A—H12B	109.3	C13B—C12B—H12D	108.6
C11A—C12A—H12B	109.3	C11B—C12B—H12D	108.6
H12A—C12A—H12B	108.0	H12C—C12B—H12D	107.5
C14A—C13A—C12A	110 (3)	C14B—C13B—C12B	109 (3)
C14A—C13A—C18A	113 (3)	C14B—C13B—C18B	109 (3)
C12A—C13A—C18A	114 (3)	C12B—C13B—C18B	109 (3)
C14A—C13A—C17A	102 (3)	C14B—C13B—C17B	102 (3)
C12A—C13A—C17A	114 (3)	C12B—C13B—C17B	117 (3)
C18A—C13A—C17A	102 (3)	C18B—C13B—C17B	110 (3)
C13A—C14A—C8A	116 (3)	C15B—C14B—C13B	107 (3)
C13A—C14A—C15A	106 (3)	C15B—C14B—C8B	116 (3)
C8A—C14A—C15A	117 (3)	C13B—C14B—C8B	115 (3)
C13A—C14A—H14A	105.7	C15B—C14B—H14B	105.9
C8A—C14A—H14A	105.7	C13B—C14B—H14B	105.9
C15A—C14A—H14A	105.7	C8B—C14B—H14B	105.9
C14A—C15A—C16A	102 (2)	C14B—C15B—C16B	103 (3)
C14A—C15A—H15A	111.4	C14B—C15B—H15C	111.2
C16A—C15A—H15A	111.4	C16B—C15B—H15C	111.2
C14A—C15A—H15B	111.4	C14B—C15B—H15D	111.2
C16A—C15A—H15B	111.4	C16B—C15B—H15D	111.2
H15A—C15A—H15B	109.3	H15C—C15B—H15D	109.2
C17A—C16A—C15A	107 (3)	C17B—C16B—C15B	105 (3)
C17A—C16A—H16A	110.3	C17B—C16B—H16C	110.8
C15A—C16A—H16A	110.3	C15B—C16B—H16C	110.8
C17A—C16A—H16B	110.3	C17B—C16B—H16D	110.8
C15A—C16A—H16B	110.3	C15B—C16B—H16D	110.8
H16A—C16A—H16B	108.5	H16C—C16B—H16D	108.9
C17A—O17A—H17A	109.5	C17B—O17B—H17B	109.5
O17A—C17A—C16A	104 (3)	C20B—C17B—O17B	106 (3)
O17A—C17A—C20A	107 (3)	C20B—C17B—C16B	116 (4)
C16A—C17A—C20A	113 (3)	O17B—C17B—C16B	109 (2)
O17A—C17A—C13A	107 (3)	C20B—C17B—C13B	115 (3)
C16A—C17A—C13A	106 (3)	O17B—C17B—C13B	107 (3)
C20A—C17A—C13A	119 (3)	C16B—C17B—C13B	104 (3)
C13A—C18A—H18A	109.5	C13B—C18B—H18D	109.5
C13A—C18A—H18B	109.5	C13B—C18B—H18E	109.5
H18A—C18A—H18B	109.5	H18D—C18B—H18E	109.5
C13A—C18A—H18C	109.5	C13B—C18B—H18F	109.5
H18A—C18A—H18C	109.5	H18D—C18B—H18F	109.5
H18B—C18A—H18C	109.5	H18E—C18B—H18F	109.5
C10A—C19A—H19A	109.5	C10B—C19B—H19D	109.5
C10A—C19A—H19B	109.5	C10B—C19B—H19E	109.5
H19A—C19A—H19B	109.5	H19D—C19B—H19E	109.5
C10A—C19A—H19C	109.5	C10B—C19B—H19F	109.5
H19A—C19A—H19C	109.5	H19D—C19B—H19F	109.5
H19B—C19A—H19C	109.5	H19E—C19B—H19F	109.5
O20A—C20A—C17A	122 (4)	O20B—C20B—C17B	121 (4)
O20A—C20A—C21A	125 (4)	O20B—C20B—C21B	121 (4)
C17A—C20A—C21A	112 (3)	C17B—C20B—C21B	118 (4)
C21A—O21A—H21A	109.5	C21B—O21B—H21C	109.5
O21A—C21A—C20A	107 (3)	O21B—C21B—C20B	105 (3)
O21A—C21A—H3	110.4	O21B—C21B—H4	110.7
C20A—C21A—H3	110.4	C20B—C21B—H4	110.7
O21A—C21A—H21B	110.4	O21B—C21B—H21D	110.7
C20A—C21A—H21B	110.4	C20B—C21B—H21D	110.7
H3—C21A—H21B	108.6	H4—C21B—H21D	108.8