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Figure 1
Structures of d-cGrx1, m-cGrx1 and the m-cGrx1–cMsrA complex. (a) d-cGrx1 is shown in cyan (left) and the domain-swapped structures of m-cGrx are shown in magenta (β3-swap; middle) and orange (β1-swap; right). (b) The heterohexameric state contains two cMsrA molecules and four cGrx1 molecules: cMsrA is in green, a domain-swapped dimer of cGrx1 is in blue and purple, and a disulfide dimer of cGrx1 is in beige. The catalytic pocket (CP) of cMsrA is indicated by a yellow circle. (c) Diagram of the heterohexamer of the monothiol cGrx1–cMsrA complex. The interfaces between cGrx1 and cMsrA are labeled in translucent boxes and disulfide bridges are shown as red lines. (d) The monomeric d-cGrx1 consists of three α-helices (α1, α2 and α3) and four β-sheets (β1, β2, β3 and β4). The N- and C-termini of d-cGrx1 are labeled N and C, respectively. Cys13 and Cys16 form a disulfide bond, which is represented as a stick.

IUCrJ
Volume 7| Part 6| November 2020| Pages 1019-1027
ISSN: 2052-2525
https://doi.org/10.1107/S2052252520011598