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Figure 1
(a) Structure of the 3CL Mpro dimer from SARS-CoV-2 (PDB entry 6wqf; Kneller et al., 2020BB18) in cartoon representation. The locations of the 12 amino-acid substitutions relative to the SARS-CoV enzyme are shown as violet spheres in one monomer. The catalytic Cys–His dyad is shown as sticks in each monomer. (b) Amino-acid sequence alignment of 3CL Mpro from SARS-CoV-2 (first row) and SARS-CoV (second row) indicating the positions of the amino-acid substitutions. The catalytic His41 and Cys145 are highlighted in black.

IUCrJ
Volume 7| Part 6| November 2020| Pages 1028-1035
ISSN: 2052-2525
https://doi.org/10.1107/S2052252520012634