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Figure 2
Verification of the oG*–hOgg1 system in solution and in crystals. (a) Enzymatic activity of WT and N149C hOgg1 with G-, oG- or oG*-containing oligonucleotides. The double-stranded DNA was incubated with 0, 1 or 2 molar equivalents of WT or N149C hOgg1. (b) A representative picture of G*O co-crystals. (c) HPLC chromatograms of (i) oG*-containing oligonucleotide, (ii) double-stranded DNA before complex formation and (iii) double-stranded DNA recovered from the crystals. (d) Diffraction power of G*O (square data points, solid line) and lysozyme (circular data points, dashed line) crystals versus 365 nm illumination dose. The red square represents the dose used to obtain the G*Olight data set.

IUCrJ
Volume 12| Part 5| September 2025| Pages 515-522
ISSN: 2052-2525
https://doi.org/10.1107/S2052252525006062