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Figure 1
Schematic drawing of MAC assembly. Activation of the alternative pathway or the classical/lectin pathway generates C5 convertases (C3bBb3b and C4b2a3b, respectively) that cleave C5; the resulting C5b (orange) binds C6 (red) at the membrane. C5b6 recruits C7 (purple), C8 (blue) and C9 (turquoise), which polymerizes to form a giant β-barrel pore in lipid bilayers. CD59, clusterin and vitronectin are complement regulators that inhibit MAC formation.

IUCrJ
Volume 13| Part 3| May 2026| Pages 221-227
ISSN: 2052-2525
https://doi.org/10.1107/S2052252526002927