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![[Figure 2]](eh5025fig2mag.jpg)
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Figure 2
(a) First cryo-EM MAC structure (EMDB entry EMD-3134, 8.5 Å; Serna et al., 2016  ). (b) Cryo-EM structures of open (EMDB entry EMD-0106, 5.6 Å, top; Menny et al., 2018) and closed conformations (EMDB entry EMD-0107, 5.6 Å, bottom; Menny et al., 2018) of the MAC pore. (c) Atomic model of the MAC closed conformation (PDB entry 6h04; Menny et al., 2018). Complement proteins coloured as in Fig. 1. (d) Coulombic electrostatic potential ranging from −10 (red) to 10 (blue) kcal (mol·e)−1 calculated from the model shown in (c). The position of the membrane relative to the models is indicated by double black lines. The boxed region highlights a patch of positively charged residues within the membrane-interacting regions of C6, C7 and C8. |
![[Figure 2]](eh5025fig2.jpg)
ISSN: 2052-2525
CRYO | EM
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