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Figure 1
Diagram of mix-and-spray setup for microcrystal deposition onto TEM grids. Microcrystals are propelled through the nozzle (a) via an HPLC pump and droplets are formed and focused using nitrogen gas. Droplets are propelled across a 5 cm space onto grids driven by gravity into liquid ethane. Adjustment of both liquid flow rate and gas speed allows optimization of droplet size and distribution onto the grid. (b) Physical apparatus highlighting the grid, tweezers, isolated chamber and nozzle. Tweezers are shown in a mid-plunge position after exiting the shuttered chamber above.

IUCrJ
Volume 13| Part 4| July 2026|
ISSN: 2052-2525
https://doi.org/10.1107/S2052252526005129