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Figure 2
MATα22 interaction with the MATβV1 N-terminus. (A) Cartoon representation of MATα2 tetramer (marine blue) interactions with MATβV1 (cornflower blue, salmon and light green). (B) Zoomed-in view of the MATα2 chain A interaction interface with the N-terminal hairpin of MATβV1, located within the MATα2 groove at the northern side; the ionic bond between Lys235 MATα2 and Glu5 MATβV1 is indicated by the dotted red line. His89 MATα2 in Chain A is in the conformation accommodating MATβV1 for the complex formation. (C) The steric clash of His89 MATα2 in Chain C and Chain D preventing full binding of the MATβV1 N-terminus (Coulomb density showing β-hairpin of one MATβV1 at the southern end modelled with 50% occupancy). (D) Coulomb density at the southern end interface showing two possible conformations of MATβV1 with equal probabilities of 50%.

IUCrJ
Volume 13| Part 4| July 2026|
ISSN: 2052-2525
https://doi.org/10.1107/S2052252526005075