journal menu
![[Figure 1]](hi5657fig1mag.jpg)
|
|
Figure 1
SARS-CoV-2 trimeric spike proteins are captured in discrete `RBD up' and `RBD down' states by single-particle cryo-EM and cryo-ET. (a) High-resolution structures of SARS-CoV-2 spike proteins in complex with ACE2 indicate a trimeric spike protein with ACE2 bound to up RBDs (EMDB-25760). (b) Cryo-ET of SARS-CoV-2 virions indicate that prefusion spike proteins can have all RBDs down, one RBD up, or two RBDs up in the absence of ACE2 (PDB IDs 6vyb, 6vxx and 6x2b) (Henderson et al., 2020  ; Ke et al., 2020; Walls et al., 2020). (c) Atomic models of different RBD-directed neutralizing antibodies which have preferential binding to RBDs in the down and/or up position (PDB IDs 7mjh and 7mjj) (Zhu et al., 2021). |
![[Figure 1]](hi5657fig1.jpg)
ISSN: 2052-2525
CRYO | EM
Open 
access
access
