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Figure 3
GND-135 eliminates PDE6 cross-reactivity while maintaining VCP/p97 potency. (a) Detailed view of the binding pose of GND-135 in the VCP/p97 binding site. Key inter­acting residues are shown in stick representation, with hy­dro­gen bonds indicated by the dashed orange lines. (b) The binding pose of GND-135 in the binding pocket is unambiguously visualized as indicated by the experimental cryo-EM density in the map. (c) Ligplot showing the specific residues involved in the binding of GND-135 in the VCP/p97 binding pocket. Hydrogen bonds are indicated by green dashed lines.

IUCrJ
Volume 13| Part 4| July 2026|
ISSN: 2052-2525
https://doi.org/10.1107/S2052252526004604