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![[Figure 2]](rq5020fig2mag.jpg)
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Figure 2
Structure and function of AQPs exemplified by AQP4. (a) Secondary structure of AQPs. The conserved NPA motifs and Arg residue at the ar/R filter are indicated. (b) Tetrameric structure of AQP4 (PDB ID 2zz9) (Tani et al., 2009  ) shown from side and extracellular views. (c) Monomer conformation of AQP4 shown from the side and an enlarged view of the pore region with NPA motifs (Asn97 at HB and Asn213 at HE) and ar/R filter (Phe77, His201, Ala210 and Arg216). Arrangement of seven modeled water molecules, excluding weak density corresponding to one water molecule at the ar/R filter (Tani et al., 2009). Distances between water molecules and coordinated atoms are also indicated. (d) Monomer conformation of AQP4 from an extracellular view, highlighting the ar/R filter residues. (e) Monomer conformation of GlpF (PDB ID 1lda) (Tajkhorshid et al., 2002) from an extracellular view, highlighting the ar/R filter residues. |
![[Figure 2]](rq5020fig2.jpg)
ISSN: 2052-2525
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