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Figure 4
Single-particle cryo-EM structures of orthodox AQPs. (a) Tetrameric structural model of AQP2. (b) AQP2 C-terminal features observed in single-particle cryo-EM. Representative class averages of full-length AQP2 and its C-terminal deletion mutant. (c) Structure of AQPZ with ALFA tag bound to nanobody. (d) Structure of ANK1 complex containing AQP1. (e) Structure of AQP4. (f) Structure of AQP4 in complex with Fab58. (g) Structure of AQP4 in complex with Fab186. More detailed structural information is summarized in Table 1[link].

IUCrJ
Volume 13| Part 4| July 2026|
ISSN: 2052-2525
https://doi.org/10.1107/S2052252526003234