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Figure 5
Single-particle cryo-EM structures of aqua­glyceroporins AQP7 and AQP3. (a) Structural model of AQP7 forming a dimer of tetramers (right). Enlarged view of the AQP7 monomer from the extracellular view is shown, highlighting the ar/R filter residues (left). (b) Conformation of docked AQP7 monomers. (c) Extracellular and side views of the monomer conformation of AQP7 in complex with an inhibitor, highlighting the ar/R filter residues. Helices are partially removed in the side view for clarity. (d) Monomer conformation of AQP3 in DDM micelles. (e) Monomer conformation of AQP3 in lipid nanodiscs. (f) Monomer conformation of GlpF in lipid nanodiscs. (g) Monomer conformation of AQP7 in lipid nanodiscs. (h)–(j) Monomer conformations of AQP3 in lipid nanodiscs at (h) pH 8.0, (i) pH 5.5 and (j) pH 8.0 with H2O2. More detailed structural information is provided in Table 1[link].

IUCrJ
Volume 13| Part 4| July 2026|
ISSN: 2052-2525
https://doi.org/10.1107/S2052252526003234