Comparison of human and bacterial monofunctional catalase structures obtained by electron cryomicroscopy

Slowik, D.; Li, J.; Wilson, H.; Shtyrov, A.; Chen, S.; McMullan, G.; Russo, C.J.; Murshudov, G.; Henderson, R.

doi:10.1107/S2052252526008845

Figure 3
Side-by-side NADPH environments. Cat_T blue, cat_H pink. Although the NADPH conformation itself is very similar, the surrounding residues and water molecules have significant differences. Of the six surrounding residues that are labelled, four have significantly different identities. Other residues near NADPH are also discussed in the text; H222(H) is in front of this slice with its NE2 forming a 3.04 Å hydrogen bond with OX3 of NADPH; Y183(T,L)/F198(H) is behind the slice and 3.4 Å from NADPH.

IUCrJ

Volume 13| Part 6| November 2026| Pages 807-818

ISSN: 2052-2525

https://doi.org/10.1107/S2052252526008845

CRYO | EM

Open

access