Comparison of human and bacterial monofunctional catalase structures obtained by electron cryomicroscopy

Slowik, D.; Li, J.; Wilson, H.; Shtyrov, A.; Chen, S.; McMullan, G.; Russo, C.J.; Murshudov, G.; Henderson, R.

doi:10.1107/S2052252526008845

Figure 4
Side-by-side images of the aqueous channel in cat_T, cat_L and cat_H through which H₂O₂ gains access to the active site, leading from the haem group to the molecular surface at the top. The Gaussian surface was created from the coordinates without the haem and water molecules. The atomic model includes both. The water molecules are shown as red spheres, with the two at the haem iron and the active-site histidine/asparagine in almost identical positions. The ordered water molecules higher in the channel have slightly different locations, and less well ordered water fills the remainder of the channels.

IUCrJ

Volume 13| Part 6| November 2026| Pages 807-818

ISSN: 2052-2525

https://doi.org/10.1107/S2052252526008845

CRYO | EM

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