journal menuforthcoming articles
The following articles are a selection of those recently accepted for publication in IUCrJ.
See also Forthcoming articles in all IUCr journals.
research papersA comparative study of single-particle cryo-EM with liquid-nitrogen and liquid-helium cooling
Radiation damage is the most fundamental limitation for achieving high resolution in cryo-EM, and is expected to be reduced at liquid helium temperature. Surprisingly, cryo-EM reconstructions of apoferritin samples cooled with liquid helium showed no improvement in resolution over liquid nitrogen cooled samples, but substantially more beam-induced particle motion.
research papersDiversifying Molecular and Topological Space via a Supramolecular Solid-State Synthesis: A Purely Organic mok Net Sustained by Hydrogen Bonds
A hydrogen-bond-directed [2+2] photodimerization performed in the organic solid state is used to generate a head-to-head (HH) cyclobutane photoproduct functionalized with cis-phenolic and cis-pyridyl groups. The photoproduct self-assembles as a pure form in the solid state to form a rare three-dimensional hydrogen-bonded network with a topology that conforms to a mok net. The construction of the HH cyclobutane is achieved using a newly introduced supramolecular protecting group strategy.
research papersA cryo-EM grid preparation device for time-resolved structural studies
Time-resolved structural studies are becoming an important tool in understanding biological function. Here we describe a cryo-EM grid freezing device capable of rapidly mixing and plunge freezing grids within 10 ms.
research papersEngineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein
The development and characterization of a surrogate system to support drug discovery targeting a complex heteromeric human glycine receptor is described.
research papersNew Small-Angle X-ray Scattering Model for Polymer Spherulite with Limited Lateral Size of Lamellar Crystals
SAXS in real polymer system is highly from the scattering induced by evanescent wave. An evidence for the existence of the evanescent wave was identified in the scattering of isotactic polypropylene.
research papersThe DRS–AIMP2–EPRS subcomplex acts as a pivot in the multi-tRNA synthetase complex
The ternary complex structure of human aspartyl-tRNA synthetase (DRS) and two glutathione S-transferase domains from aminoacyl-tRNA synthase complex-interacting multifunctional protein 2 and glutamyl-prolyl-tRNA synthetase (AIMP2GST and EPRSGST, respectively) was determined at 3.6 Å resolution, providing insight into the pivotal role of the ternary complex within the multi-tRNA synthetase complex.
research papersConformational characterization of full-length X-chromosome-linked inhibitor of apoptosis protein (XIAP) through an integrated approach
The anti-apoptotic multidomain protein XIAP is shown to be a compact dimer in solution as determined by an integrative approach combining NMR, SAXS, EPR and molecular modelling.
research papersresearch papersResolution and dose dependence of radiation damage in biomolecular systems
Data from several radiation-damage studies using protein crystals are reanalyzed to determine the local dose- and resolution-dependent decay of diffracted intensity at T = 100 K. The results are inconsistent with long-accepted models and with a proposed linear scaling between maximum tolerable dose and resolution, but are reproduced by a simple, physics-based model.
