On the application of phase relationships to complex structures. XX. RANTAN for large structures and fragment development

The RANTAN procedure has been used to solve an unknown structure with 100 atoms in the asymmetric unit. In a test of the power of the method a synthetic structure with 234 atoms in space group P1 was solved without difficulty. RANTAN is also very effective as a multisolution fragment-development procedure with as little as 10% of the structure in the fragment.