Supporting information
Crystallographic Information File (CIF) https://doi.org/10.1107/S0108270106011620/fg3014sup1.cif | |
Structure factor file (CIF format) https://doi.org/10.1107/S0108270106011620/fg30149sup2.hkl |
CCDC reference: 609427
NMR spectra were recorded of samples dissolved in CDCl3 (1H at 400 MHz, with residual CHCl3 as ref. δH 7.25 p.p.m.; 13C at 100 MHz, with the center line of the solvent resonance δC 77.0 p.p.m. as ref.) EIMS were measured using 70 eV sample bombardment. 18-Deoxylycoctamol, (8), m.p. 500–505 K (from Me2CO–hexanes); EIMS m/z 403.2352, C23H33NO5 requires 403.2359; 1H NMR: δH 5.38 (1H, br s, H-14), 5.12 (1H, br s, H-15A) and 5.14 (1H, br s, H-15B), 4.19 (1H, d, J = 2 Hz, H-17), 4.13 (2H, br s, H-16), 3.93 (1H, dq, J = 14.1 and 7.1 Hz, H-20A), 3.57 (3H, s, OCH3), 3.38 (1H, br m), 3.30 (3H, s, OCH3), 3.21 (1H, d, J = 4.1 Hz, H-6), 3.07 (1H, br m), 2.97 (1H, dq, J = 14.1 and 7.1 Hz, H-20B), 2.39 (3H, m), 1.99 (1H, m), 1.94 (1H, m), 1.58 (1H, dd, J = 4.1 and 2.1 Hz, H-5), 1.31 (2H, m), 1.27 (3H, s, H-18), and 1.12 (3H, t, J = 7.1 Hz, H-21); 13C NMR: δC 172.6 (s), 149.1 (s), 143.9 (s), 121.5 (d), 113.0 (t), 85.4 (d), 83.3 (d), 61.7 (t), 60.3 (q), 56.9 (d), 56.5 (q), 53.2 (d), 47.7 (d), 39.0 (t), 36.3 (t), 36.0 (t), 25.2 (t), 22.2 (q), and 11.7 (q). 18-Deoxydihydrolycoctamone (9), m.p. 484–486 K (from Me2CO–hexanes); EIMS m/z 389.2565, C23H35NO4 requires 389.2566; 1H NMR: δH 5.27 (1H, br s, H-15A), 5.25 (1H, br s, H-15B), 4.08 (1H, d, J = 1.5 Hz, H-17), 3.99 (1H, dq, H-20A), 3.55 (3H, s, OCH3), 3.28 (3H, s, OCH3), 3.22 (1H, d, J = 4 Hz, H-6), 3.01 (1H, m), 2.99 (1H, dq, H-20B), 2.76 (1H, m), 2.1–1.8 (4H, m), 1.75–1.55 (4H, m), 1.49 (1H, dd, J = 1.5 and 4 Hz, H-5), 1.26 (3H, s, H-18), 1.13 (3H, t, J = 7.1 Hz, H-21), 0.96 (3H, d, J = (?)Hz, H-15) and 0.94 (1H, m); 13C NMR: δC 172.7 (s), 144.1 (s), 112.9 (t), 84.5 (d), 83.5 (d), 78.4 (s), 60.2 (q), 56.3 (d), 56.2 (q), 54.1 (d), 50.9 (q), 42.8 (s), 39.2 (t), 39.1 (d), 38.6 (t), 38.5 (s), 36.5 (t), 34.6 (d), 33.3 (t), 25.4 (t), 22.1 (q), 18.8 (q), and 11.7 (q).
The H atoms were located in difference Fourier syntheses and were included in the refinements at idealized positions (C—H = 0.96 Å) with isotropic displacement parameters equal to 1.5 (hydroxy atom) and 1.2 (the rest) times the equivalent displacement parameters of the atoms to which they were bonded. The final difference map was free of any chemically significant features. An absolute structure was not established in this analysis; Friedel pairs of reflections were merged.
Data collection: COLLECT (Nonius, 1998); cell refinement: HKL DENZO (Otwinowski & Minor, 1997); data reduction: SCALEPACK (Otwinowski & Minor, 1997); program(s) used to solve structure: SAPI91 (Fan, 1991); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997); molecular graphics: ORTEPII (Johnson, 1976); software used to prepare material for publication: SHELXL97).
Fig. 1. An ORTEPII (Johnson, 1976) drawing of (9), with the crystallographic numbering scheme; displacement ellipsoids have been plotted at the 25% probability level. |
C23H35NO4 | F(000) = 424 |
Mr = 389.52 | Dx = 1.244 Mg m−3 |
Monoclinic, P21 | Mo Kα radiation, λ = 0.71073 Å |
Hall symbol: P 2yb | Cell parameters from 4396 reflections |
a = 9.675 (5) Å | θ = 3.8–27.5° |
b = 10.401 (6) Å | µ = 0.08 mm−1 |
c = 11.063 (7) Å | T = 295 K |
β = 110.86 (3)° | Needle, colorless |
V = 1040.3 (10) Å3 | 0.12 × 0.04 × 0.03 mm |
Z = 2 |
Nonius KappaCCD diffractometer | 2486 independent reflections |
Radiation source: fine-focus sealed tube | 1390 reflections with I > 2σ(I) |
Graphite monochromator | Rint = 0.060 |
ω and ϕ scans | θmax = 27.5°, θmin = 3.8° |
Absorption correction: multi-scan (SORTAV; Blessing, 1997) | h = −12→12 |
Tmin = 0.990, Tmax = 0.997 | k = −12→13 |
4396 measured reflections | l = −14→14 |
Refinement on F2 | Hydrogen site location: inferred from neighbouring sites |
Least-squares matrix: full | H-atom parameters constrained |
R[F2 > 2σ(F2)] = 0.051 | w = 1/[σ2(Fo2) + (0.057P)2] where P = (Fo2 + 2Fc2)/3 |
wR(F2) = 0.124 | (Δ/σ)max < 0.001 |
S = 1.01 | Δρmax = 0.17 e Å−3 |
2486 reflections | Δρmin = −0.20 e Å−3 |
255 parameters | Extinction correction: SHELXL97, Fc*=kFc[1+0.001xFc2λ3/sin(2θ)]-1/4 |
1 restraint | Extinction coefficient: 0.048 (8) |
Primary atom site location: structure-invariant direct methods | Absolute structure: Flack H D (1983), Acta Cryst. A39, 876-881 |
Secondary atom site location: difference Fourier map |
C23H35NO4 | V = 1040.3 (10) Å3 |
Mr = 389.52 | Z = 2 |
Monoclinic, P21 | Mo Kα radiation |
a = 9.675 (5) Å | µ = 0.08 mm−1 |
b = 10.401 (6) Å | T = 295 K |
c = 11.063 (7) Å | 0.12 × 0.04 × 0.03 mm |
β = 110.86 (3)° |
Nonius KappaCCD diffractometer | 2486 independent reflections |
Absorption correction: multi-scan (SORTAV; Blessing, 1997) | 1390 reflections with I > 2σ(I) |
Tmin = 0.990, Tmax = 0.997 | Rint = 0.060 |
4396 measured reflections |
R[F2 > 2σ(F2)] = 0.051 | 1 restraint |
wR(F2) = 0.124 | H-atom parameters constrained |
S = 1.01 | Δρmax = 0.17 e Å−3 |
2486 reflections | Δρmin = −0.20 e Å−3 |
255 parameters | Absolute structure: Flack H D (1983), Acta Cryst. A39, 876-881 |
x | y | z | Uiso*/Ueq | ||
O1 | 0.7998 (3) | 0.2269 (3) | 0.3992 (3) | 0.0557 (8) | |
O2 | 0.5504 (3) | 0.0570 (3) | −0.0709 (2) | 0.0531 (7) | |
O3 | 0.2990 (3) | −0.1443 (3) | 0.2343 (3) | 0.0531 (7) | |
O4 | 0.5389 (3) | −0.3278 (2) | 0.3259 (3) | 0.0533 (7) | |
H4 | 0.5147 | −0.3577 | 0.2527 | 0.080* | |
N1 | 0.6941 (3) | −0.0023 (3) | 0.1308 (3) | 0.0406 (8) | |
C1 | 0.6472 (4) | 0.2025 (3) | 0.3249 (4) | 0.0451 (10) | |
H1 | 0.5891 | 0.2351 | 0.3726 | 0.054* | |
C2 | 0.6044 (4) | 0.2709 (4) | 0.1956 (4) | 0.0524 (11) | |
H2A | 0.6753 | 0.2512 | 0.1558 | 0.063* | |
H2B | 0.6040 | 0.3619 | 0.2101 | 0.063* | |
C3 | 0.4533 (4) | 0.2288 (4) | 0.1045 (4) | 0.0520 (10) | |
H3A | 0.4316 | 0.2656 | 0.0201 | 0.062* | |
H3B | 0.3810 | 0.2571 | 0.1397 | 0.062* | |
C4 | 0.4413 (4) | 0.0809 (4) | 0.0909 (3) | 0.0421 (9) | |
C5 | 0.4646 (4) | 0.0220 (4) | 0.2231 (3) | 0.0390 (9) | |
H5 | 0.3957 | 0.0640 | 0.2546 | 0.047* | |
C6 | 0.4379 (4) | −0.1243 (4) | 0.2183 (4) | 0.0416 (9) | |
H6 | 0.4322 | −0.1555 | 0.1350 | 0.050* | |
C7 | 0.5658 (4) | −0.1939 (4) | 0.3221 (3) | 0.0406 (9) | |
C8 | 0.7075 (4) | −0.1644 (4) | 0.2980 (3) | 0.0410 (9) | |
C9 | 0.5828 (4) | −0.1356 (4) | 0.4537 (4) | 0.0469 (9) | |
H9 | 0.4882 | −0.1403 | 0.4633 | 0.056* | |
C10 | 0.6290 (4) | 0.0078 (4) | 0.4550 (3) | 0.0421 (9) | |
H10 | 0.5632 | 0.0583 | 0.4833 | 0.051* | |
C11 | 0.6205 (4) | 0.0550 (4) | 0.3196 (3) | 0.0389 (8) | |
C12 | 0.7788 (4) | 0.0156 (4) | 0.5672 (4) | 0.0537 (11) | |
H12A | 0.7912 | 0.0996 | 0.6055 | 0.064* | |
H12B | 0.8556 | 0.0001 | 0.5330 | 0.064* | |
C13 | 0.7708 (5) | −0.0860 (5) | 0.6598 (4) | 0.0689 (13) | |
H13 | 0.7069 | −0.0563 | 0.7034 | 0.083* | |
C14 | 0.6988 (5) | −0.1980 (4) | 0.5721 (4) | 0.0567 (11) | |
H14A | 0.7671 | −0.2448 | 0.5435 | 0.068* | |
H14B | 0.6511 | −0.2561 | 0.6122 | 0.068* | |
C15 | 0.8104 (4) | −0.2519 (4) | 0.3088 (4) | 0.0537 (11) | |
H15A | 0.8991 | −0.2304 | 0.2931 | 0.064* | |
H15B | 0.7948 | −0.3384 | 0.3316 | 0.064* | |
C16 | 0.9141 (5) | −0.1143 (5) | 0.7692 (4) | 0.0814 (16) | |
H16A | 0.8982 | −0.1814 | 0.8224 | 0.098* | |
H16B | 0.9882 | −0.1410 | 0.7353 | 0.098* | |
H16C | 0.9467 | −0.0379 | 0.8201 | 0.098* | |
C17 | 0.7249 (4) | −0.0230 (3) | 0.2719 (3) | 0.0380 (9) | |
H17 | 0.8251 | 0.0027 | 0.3188 | 0.046* | |
C18 | 0.2909 (4) | 0.0477 (5) | −0.0095 (4) | 0.0561 (11) | |
H18A | 0.2827 | −0.0440 | −0.0193 | 0.067* | |
H18B | 0.2132 | 0.0793 | 0.0175 | 0.067* | |
H18C | 0.2825 | 0.0863 | −0.0906 | 0.067* | |
C19 | 0.5656 (4) | 0.0415 (4) | 0.0441 (3) | 0.0410 (9) | |
C20 | 0.8143 (4) | −0.0370 (4) | 0.0855 (4) | 0.0519 (11) | |
H20A | 0.7800 | −0.0277 | −0.0069 | 0.062* | |
H20B | 0.8414 | −0.1249 | 0.1082 | 0.062* | |
C21 | 0.9517 (5) | 0.0440 (5) | 0.1429 (5) | 0.0787 (15) | |
H21A | 1.0259 | 0.0163 | 0.1096 | 0.094* | |
H21B | 0.9275 | 0.1324 | 0.1202 | 0.094* | |
H21C | 0.9889 | 0.0352 | 0.2354 | 0.094* | |
C22 | 0.8241 (5) | 0.3500 (5) | 0.4584 (5) | 0.0790 (15) | |
H22A | 0.9276 | 0.3627 | 0.5058 | 0.095* | |
H22B | 0.7883 | 0.4170 | 0.3952 | 0.095* | |
H22C | 0.7710 | 0.3523 | 0.5169 | 0.095* | |
C23 | 0.2121 (4) | −0.2467 (5) | 0.1608 (5) | 0.0688 (13) | |
H23A | 0.1220 | −0.2545 | 0.1781 | 0.083* | |
H23B | 0.1891 | −0.2315 | 0.0702 | 0.083* | |
H23C | 0.2681 | −0.3247 | 0.1855 | 0.083* |
U11 | U22 | U33 | U12 | U13 | U23 | |
O1 | 0.0521 (16) | 0.0482 (18) | 0.0597 (17) | −0.0058 (14) | 0.0115 (13) | 0.0007 (14) |
O2 | 0.0666 (17) | 0.0563 (18) | 0.0412 (15) | 0.0020 (14) | 0.0252 (13) | 0.0066 (14) |
O3 | 0.0454 (14) | 0.0602 (18) | 0.0593 (16) | −0.0057 (14) | 0.0256 (13) | −0.0040 (15) |
O4 | 0.0697 (17) | 0.0387 (16) | 0.0509 (16) | −0.0062 (13) | 0.0207 (15) | 0.0018 (13) |
N1 | 0.0403 (17) | 0.0438 (19) | 0.0425 (17) | 0.0004 (14) | 0.0207 (15) | 0.0021 (15) |
C1 | 0.045 (2) | 0.040 (2) | 0.050 (2) | 0.0006 (18) | 0.0170 (18) | −0.0025 (18) |
C2 | 0.070 (3) | 0.035 (2) | 0.054 (3) | −0.0012 (19) | 0.025 (2) | 0.0026 (19) |
C3 | 0.062 (2) | 0.046 (2) | 0.048 (2) | 0.010 (2) | 0.019 (2) | 0.005 (2) |
C4 | 0.0408 (19) | 0.045 (2) | 0.040 (2) | 0.0005 (17) | 0.0139 (16) | 0.0016 (18) |
C5 | 0.0395 (19) | 0.042 (2) | 0.0386 (19) | 0.0039 (16) | 0.0176 (15) | −0.0012 (17) |
C6 | 0.045 (2) | 0.046 (2) | 0.0370 (19) | −0.0007 (18) | 0.0188 (16) | 0.0002 (17) |
C7 | 0.046 (2) | 0.041 (2) | 0.038 (2) | 0.0015 (17) | 0.0188 (17) | 0.0036 (18) |
C8 | 0.045 (2) | 0.042 (2) | 0.036 (2) | 0.0025 (18) | 0.0147 (16) | 0.0011 (17) |
C9 | 0.053 (2) | 0.048 (2) | 0.044 (2) | −0.0056 (19) | 0.0230 (18) | 0.0019 (19) |
C10 | 0.050 (2) | 0.042 (2) | 0.037 (2) | 0.0063 (18) | 0.0188 (17) | −0.0013 (17) |
C11 | 0.0423 (19) | 0.039 (2) | 0.0374 (19) | 0.0016 (17) | 0.0163 (15) | 0.0001 (17) |
C12 | 0.065 (2) | 0.053 (3) | 0.041 (2) | −0.003 (2) | 0.0157 (19) | −0.0039 (19) |
C13 | 0.081 (3) | 0.058 (3) | 0.054 (3) | 0.002 (2) | 0.006 (2) | 0.007 (2) |
C14 | 0.069 (3) | 0.055 (3) | 0.044 (2) | −0.001 (2) | 0.018 (2) | 0.009 (2) |
C15 | 0.055 (2) | 0.051 (2) | 0.057 (3) | 0.008 (2) | 0.023 (2) | 0.005 (2) |
C16 | 0.090 (3) | 0.074 (4) | 0.057 (3) | 0.004 (3) | −0.002 (3) | 0.012 (3) |
C17 | 0.0383 (19) | 0.040 (2) | 0.0346 (19) | 0.0007 (16) | 0.0116 (15) | −0.0009 (16) |
C18 | 0.047 (2) | 0.070 (3) | 0.049 (2) | 0.002 (2) | 0.0137 (18) | 0.016 (2) |
C19 | 0.047 (2) | 0.039 (2) | 0.037 (2) | −0.0046 (18) | 0.0155 (16) | −0.0016 (18) |
C20 | 0.054 (2) | 0.056 (3) | 0.058 (3) | 0.007 (2) | 0.034 (2) | 0.003 (2) |
C21 | 0.056 (3) | 0.086 (4) | 0.104 (4) | −0.014 (3) | 0.042 (3) | −0.010 (3) |
C22 | 0.077 (3) | 0.060 (3) | 0.087 (4) | −0.014 (3) | 0.014 (3) | −0.007 (3) |
C23 | 0.058 (2) | 0.066 (3) | 0.081 (3) | −0.015 (3) | 0.022 (2) | −0.004 (3) |
O1—C22 | 1.419 (6) | C10—C12 | 1.538 (5) |
O1—C1 | 1.434 (4) | C10—C11 | 1.551 (5) |
O2—C19 | 1.238 (4) | C10—H10 | 0.9599 |
O3—C23 | 1.420 (5) | C11—C17 | 1.529 (5) |
O3—C6 | 1.432 (4) | C12—C13 | 1.493 (6) |
O4—C7 | 1.420 (4) | C12—H12A | 0.9601 |
O4—H4 | 0.8200 | C12—H12B | 0.9600 |
N1—C19 | 1.350 (4) | C13—C16 | 1.509 (6) |
N1—C20 | 1.466 (4) | C13—C14 | 1.517 (6) |
N1—C17 | 1.497 (5) | C13—H13 | 0.9600 |
C1—C2 | 1.517 (6) | C14—H14A | 0.9600 |
C1—C11 | 1.553 (5) | C14—H14B | 0.9600 |
C1—H1 | 0.9600 | C15—H15A | 0.9600 |
C2—C3 | 1.515 (5) | C15—H15B | 0.9600 |
C2—H2A | 0.9600 | C16—H16A | 0.9602 |
C2—H2B | 0.9600 | C16—H16B | 0.9600 |
C3—C4 | 1.547 (5) | C16—H16C | 0.9598 |
C3—H3A | 0.9600 | C17—H17 | 0.9600 |
C3—H3B | 0.9600 | C18—H18A | 0.9600 |
C4—C18 | 1.523 (5) | C18—H18B | 0.9600 |
C4—C19 | 1.525 (5) | C18—H18C | 0.9601 |
C4—C5 | 1.527 (5) | C20—C21 | 1.510 (6) |
C5—C6 | 1.541 (5) | C20—H20A | 0.9599 |
C5—C11 | 1.544 (5) | C20—H20B | 0.9599 |
C5—H5 | 0.9599 | C21—H21A | 0.9601 |
C6—C7 | 1.537 (5) | C21—H21B | 0.9599 |
C6—H6 | 0.9599 | C21—H21C | 0.9600 |
C7—C8 | 1.518 (5) | C22—H22A | 0.9600 |
C7—C9 | 1.532 (5) | C22—H22B | 0.9601 |
C8—C15 | 1.323 (5) | C22—H22C | 0.9599 |
C8—C17 | 1.521 (5) | C23—H23A | 0.9600 |
C9—C14 | 1.533 (5) | C23—H23B | 0.9600 |
C9—C10 | 1.555 (5) | C23—H23C | 0.9600 |
C9—H9 | 0.9600 | ||
C22—O1—C1 | 113.1 (3) | C10—C11—C1 | 109.0 (3) |
C23—O3—C6 | 115.4 (3) | C13—C12—C10 | 104.6 (3) |
C7—O4—H4 | 109.5 | C13—C12—H12A | 111.8 |
C19—N1—C20 | 118.8 (3) | C10—C12—H12A | 109.8 |
C19—N1—C17 | 125.5 (3) | C13—C12—H12B | 112.9 |
C20—N1—C17 | 115.7 (3) | C10—C12—H12B | 108.2 |
O1—C1—C2 | 109.7 (3) | H12A—C12—H12B | 109.5 |
O1—C1—C11 | 108.7 (3) | C12—C13—C16 | 115.5 (4) |
C2—C1—C11 | 116.2 (3) | C12—C13—C14 | 103.2 (4) |
O1—C1—H1 | 107.9 | C16—C13—C14 | 116.4 (4) |
C2—C1—H1 | 109.6 | C12—C13—H13 | 108.4 |
C11—C1—H1 | 104.4 | C16—C13—H13 | 103.4 |
C3—C2—C1 | 111.5 (3) | C14—C13—H13 | 109.8 |
C3—C2—H2A | 108.1 | C13—C14—C9 | 104.5 (3) |
C1—C2—H2A | 109.5 | C13—C14—H14A | 112.8 |
C3—C2—H2B | 109.6 | C9—C14—H14A | 108.3 |
C1—C2—H2B | 108.7 | C13—C14—H14B | 111.9 |
H2A—C2—H2B | 109.5 | C9—C14—H14B | 109.6 |
C2—C3—C4 | 111.9 (3) | H14A—C14—H14B | 109.5 |
C2—C3—H3A | 110.9 | C8—C15—H15A | 121.0 |
C4—C3—H3A | 108.6 | C8—C15—H15B | 119.0 |
C2—C3—H3B | 108.1 | H15A—C15—H15B | 120.0 |
C4—C3—H3B | 107.7 | C13—C16—H16A | 109.3 |
H3A—C3—H3B | 109.5 | C13—C16—H16B | 110.1 |
C18—C4—C19 | 110.9 (3) | H16A—C16—H16B | 109.5 |
C18—C4—C5 | 112.6 (3) | C13—C16—H16C | 109.0 |
C19—C4—C5 | 110.6 (3) | H16A—C16—H16C | 109.5 |
C18—C4—C3 | 108.4 (3) | H16B—C16—H16C | 109.5 |
C19—C4—C3 | 105.0 (3) | N1—C17—C8 | 110.0 (3) |
C5—C4—C3 | 109.0 (3) | N1—C17—C11 | 111.9 (3) |
C4—C5—C6 | 113.4 (3) | C8—C17—C11 | 108.4 (3) |
C4—C5—C11 | 110.4 (3) | N1—C17—H17 | 108.2 |
C6—C5—C11 | 110.7 (3) | C8—C17—H17 | 109.0 |
C4—C5—H5 | 106.3 | C11—C17—H17 | 109.3 |
C6—C5—H5 | 109.4 | C4—C18—H18A | 109.1 |
C11—C5—H5 | 106.4 | C4—C18—H18B | 110.3 |
O3—C6—C7 | 112.4 (3) | H18A—C18—H18B | 109.5 |
O3—C6—C5 | 107.0 (3) | C4—C18—H18C | 109.1 |
C7—C6—C5 | 111.0 (3) | H18A—C18—H18C | 109.5 |
O3—C6—H6 | 109.5 | H18B—C18—H18C | 109.5 |
C7—C6—H6 | 108.3 | O2—C19—N1 | 121.1 (3) |
C5—C6—H6 | 108.6 | O2—C19—C4 | 119.6 (3) |
O4—C7—C8 | 113.0 (3) | N1—C19—C4 | 119.2 (3) |
O4—C7—C9 | 108.6 (3) | N1—C20—C21 | 113.9 (4) |
C8—C7—C9 | 106.8 (3) | N1—C20—H20A | 108.9 |
O4—C7—C6 | 112.2 (3) | C21—C20—H20A | 108.1 |
C8—C7—C6 | 108.1 (3) | N1—C20—H20B | 108.7 |
C9—C7—C6 | 108.0 (3) | C21—C20—H20B | 107.7 |
C15—C8—C7 | 122.9 (4) | H20A—C20—H20B | 109.5 |
C15—C8—C17 | 123.5 (3) | C20—C21—H21A | 109.7 |
C7—C8—C17 | 113.4 (3) | C20—C21—H21B | 109.1 |
C7—C9—C14 | 116.3 (3) | H21A—C21—H21B | 109.5 |
C7—C9—C10 | 108.8 (3) | C20—C21—H21C | 109.6 |
C14—C9—C10 | 106.1 (3) | H21A—C21—H21C | 109.5 |
C7—C9—H9 | 107.5 | H21B—C21—H21C | 109.5 |
C14—C9—H9 | 108.7 | O1—C22—H22A | 110.1 |
C10—C9—H9 | 109.3 | O1—C22—H22B | 111.2 |
C12—C10—C11 | 118.3 (3) | H22A—C22—H22B | 109.5 |
C12—C10—C9 | 104.1 (3) | O1—C22—H22C | 107.0 |
C11—C10—C9 | 112.3 (3) | H22A—C22—H22C | 109.5 |
C12—C10—H10 | 104.6 | H22B—C22—H22C | 109.5 |
C11—C10—H10 | 109.2 | O3—C23—H23A | 110.1 |
C9—C10—H10 | 107.8 | O3—C23—H23B | 110.1 |
C17—C11—C5 | 104.3 (3) | H23A—C23—H23B | 109.5 |
C17—C11—C10 | 110.6 (3) | O3—C23—H23C | 108.2 |
C5—C11—C10 | 107.5 (3) | H23A—C23—H23C | 109.5 |
C17—C11—C1 | 114.5 (3) | H23B—C23—H23C | 109.5 |
C5—C11—C1 | 110.7 (3) | ||
C22—O1—C1—C2 | 78.3 (4) | C6—C5—C11—C1 | −179.8 (3) |
C22—O1—C1—C11 | −153.6 (4) | C12—C10—C11—C17 | 60.3 (4) |
O1—C1—C2—C3 | 169.7 (3) | C9—C10—C11—C17 | −60.9 (4) |
C11—C1—C2—C3 | 45.9 (4) | C12—C10—C11—C5 | 173.5 (3) |
C1—C2—C3—C4 | −52.4 (4) | C9—C10—C11—C5 | 52.3 (4) |
C2—C3—C4—C18 | −175.8 (3) | C12—C10—C11—C1 | −66.4 (4) |
C2—C3—C4—C19 | −57.3 (4) | C9—C10—C11—C1 | 172.4 (3) |
C2—C3—C4—C5 | 61.2 (4) | O1—C1—C11—C17 | −53.5 (4) |
C18—C4—C5—C6 | 53.3 (4) | C2—C1—C11—C17 | 70.8 (4) |
C19—C4—C5—C6 | −71.4 (4) | O1—C1—C11—C5 | −171.0 (3) |
C3—C4—C5—C6 | 173.6 (3) | C2—C1—C11—C5 | −46.7 (4) |
C18—C4—C5—C11 | 178.1 (3) | O1—C1—C11—C10 | 71.0 (4) |
C19—C4—C5—C11 | 53.4 (4) | C2—C1—C11—C10 | −164.8 (3) |
C3—C4—C5—C11 | −61.5 (4) | C11—C10—C12—C13 | −154.6 (4) |
C23—O3—C6—C7 | −94.5 (4) | C9—C10—C12—C13 | −29.3 (4) |
C23—O3—C6—C5 | 143.4 (3) | C10—C12—C13—C16 | 170.2 (4) |
C4—C5—C6—O3 | −105.6 (3) | C10—C12—C13—C14 | 42.0 (4) |
C11—C5—C6—O3 | 129.8 (3) | C12—C13—C14—C9 | −38.0 (4) |
C4—C5—C6—C7 | 131.4 (3) | C16—C13—C14—C9 | −165.6 (4) |
C11—C5—C6—C7 | 6.8 (4) | C7—C9—C14—C13 | 140.6 (4) |
O3—C6—C7—O4 | 55.9 (4) | C10—C9—C14—C13 | 19.6 (4) |
C5—C6—C7—O4 | 175.7 (3) | C19—N1—C17—C8 | 99.5 (4) |
O3—C6—C7—C8 | −178.9 (3) | C20—N1—C17—C8 | −78.6 (4) |
C5—C6—C7—C8 | −59.1 (4) | C19—N1—C17—C11 | −21.1 (5) |
O3—C6—C7—C9 | −63.7 (4) | C20—N1—C17—C11 | 160.7 (3) |
C5—C6—C7—C9 | 56.1 (4) | C15—C8—C17—N1 | 80.3 (4) |
O4—C7—C8—C15 | −14.3 (5) | C7—C8—C17—N1 | −104.7 (3) |
C9—C7—C8—C15 | 104.9 (4) | C15—C8—C17—C11 | −157.0 (3) |
C6—C7—C8—C15 | −139.1 (4) | C7—C8—C17—C11 | 18.0 (4) |
O4—C7—C8—C17 | 170.6 (3) | C5—C11—C17—N1 | 51.2 (4) |
C9—C7—C8—C17 | −70.1 (4) | C10—C11—C17—N1 | 166.4 (3) |
C6—C7—C8—C17 | 45.9 (4) | C1—C11—C17—N1 | −70.0 (4) |
O4—C7—C9—C14 | 54.3 (4) | C5—C11—C17—C8 | −70.4 (3) |
C8—C7—C9—C14 | −67.8 (4) | C10—C11—C17—C8 | 44.8 (4) |
C6—C7—C9—C14 | 176.2 (3) | C1—C11—C17—C8 | 168.5 (3) |
O4—C7—C9—C10 | 174.0 (3) | C20—N1—C19—O2 | −2.7 (5) |
C8—C7—C9—C10 | 51.9 (4) | C17—N1—C19—O2 | 179.2 (3) |
C6—C7—C9—C10 | −64.2 (3) | C20—N1—C19—C4 | −178.6 (3) |
C7—C9—C10—C12 | −120.2 (3) | C17—N1—C19—C4 | 3.4 (5) |
C14—C9—C10—C12 | 5.6 (4) | C18—C4—C19—O2 | 39.3 (5) |
C7—C9—C10—C11 | 8.9 (4) | C5—C4—C19—O2 | 165.0 (3) |
C14—C9—C10—C11 | 134.7 (3) | C3—C4—C19—O2 | −77.6 (4) |
C4—C5—C11—C17 | −69.8 (4) | C18—C4—C19—N1 | −144.8 (3) |
C6—C5—C11—C17 | 56.6 (4) | C5—C4—C19—N1 | −19.1 (5) |
C4—C5—C11—C10 | 172.8 (3) | C3—C4—C19—N1 | 98.3 (4) |
C6—C5—C11—C10 | −60.8 (4) | C19—N1—C20—C21 | 117.1 (4) |
C4—C5—C11—C1 | 53.9 (4) | C17—N1—C20—C21 | −64.6 (5) |
D—H···A | D—H | H···A | D···A | D—H···A |
O4—H4···O2i | 0.82 | 2.08 | 2.900 (4) | 177 |
Symmetry code: (i) −x+1, y−1/2, −z. |
Experimental details
Crystal data | |
Chemical formula | C23H35NO4 |
Mr | 389.52 |
Crystal system, space group | Monoclinic, P21 |
Temperature (K) | 295 |
a, b, c (Å) | 9.675 (5), 10.401 (6), 11.063 (7) |
β (°) | 110.86 (3) |
V (Å3) | 1040.3 (10) |
Z | 2 |
Radiation type | Mo Kα |
µ (mm−1) | 0.08 |
Crystal size (mm) | 0.12 × 0.04 × 0.03 |
Data collection | |
Diffractometer | Nonius KappaCCD diffractometer |
Absorption correction | Multi-scan (SORTAV; Blessing, 1997) |
Tmin, Tmax | 0.990, 0.997 |
No. of measured, independent and observed [I > 2σ(I)] reflections | 4396, 2486, 1390 |
Rint | 0.060 |
(sin θ/λ)max (Å−1) | 0.650 |
Refinement | |
R[F2 > 2σ(F2)], wR(F2), S | 0.051, 0.124, 1.01 |
No. of reflections | 2486 |
No. of parameters | 255 |
No. of restraints | 1 |
H-atom treatment | H-atom parameters constrained |
Δρmax, Δρmin (e Å−3) | 0.17, −0.20 |
Absolute structure | Flack H D (1983), Acta Cryst. A39, 876-881 |
Computer programs: COLLECT (Nonius, 1998), HKL DENZO (Otwinowski & Minor, 1997), SCALEPACK (Otwinowski & Minor, 1997), SAPI91 (Fan, 1991), SHELXL97 (Sheldrick, 1997), ORTEPII (Johnson, 1976), SHELXL97).
O1—C22 | 1.419 (6) | O4—C7 | 1.420 (4) |
O1—C1 | 1.434 (4) | N1—C19 | 1.350 (4) |
O2—C19 | 1.238 (4) | N1—C20 | 1.466 (4) |
O3—C23 | 1.420 (5) | N1—C17 | 1.497 (5) |
O3—C6 | 1.432 (4) | ||
C22—O1—C1 | 113.1 (3) | C19—N1—C17 | 125.5 (3) |
C23—O3—C6 | 115.4 (3) | C20—N1—C17 | 115.7 (3) |
C19—N1—C20 | 118.8 (3) |
D—H···A | D—H | H···A | D···A | D—H···A |
O4—H4···O2i | 0.82 | 2.08 | 2.900 (4) | 177 |
Symmetry code: (i) −x+1, y−1/2, −z. |
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During early work on the structure of the norditerpenoid alkaloid lycoctonine (1) it was discovered that the action of strong acids on the lactam derivative (2) induced the loss of two methanol units and its transformation into a product named lycoctamone (Edwards et al., 1954). Later studies revealed that lycoctamone was actually an αβ-unsaturated aldehyde and, after extensive investigations on this compound and some congeners, resulted in the proposed structure (3) (Benn et al. 1971). As shown here, this structure incorporates a revision of the stereochemistry at C-1 required (Pelletier et al., 1981; Edwards & Przybylska, 1982) as a result of an error in the original assignment in the X-ray crystallography of the derivative of (1), which had established the skeleton of these alkaloids (Przybylska & Marion, 1954; Przybylska, 1961); the same correction needs to be made to all other structures of Benn et al. (1971). The absolute structure of the lycoctonine series of compounds has been established previously (Przybylska & Marion, 1959).
The remarkable reorganization needed to produce (3) from (2) was rationalized as proceeding via a cascade of reactions, viz. a pinacolic rearrangement of (2) to (4), followed by a ring contraction of the protonated ketone via another acid-catalyzed 1,2-alkyl shift of the C-8,9 bond, to generate a carbocation that underwent a retro-Prins reaction with ring cleavage and loss of methanol forming an aldehyde, which finally underwent an acid catalyzed 1,2-elimination of another molecule of methanol. An alternative structure, (5), which would result from a fragmentation of protonated (4) induced by migration of the C-8,17 bond to generate a C-8 carbocation, appeared to be improbable because under the reaction conditions its exocyclic double bond would be expected to migrate to form a conjugated dienal system (Benn et al., 1971).
We now report the result of an X-ray crystallographic study which establishes the carbon skeleton of the lycoctamone system, and confirms the conclusions reached from the chemical investigations.
Sodium borohydride reduction of 18-deoxylycoctamone, (6), prepared from 18-deoxylycoctonam, (7) (Benn et al. 1971), gave the corresponding allylic alcohol (8), which was then subjected to hydrogenation over palladium, a process known to result in hydrogenolysis as well as reduction of the endocyclic double bond, (Edwards et al., 1954; Benn et al. 1971) to afford in good yield 18-deoxy-13β,14-dihydrolycoctam, (9), as a crystalline product. X-ray crystallography of this established the structure reported in this paper. This confirmed its molecular skeleton as that of (3), and not (5), and additionally showed that as expected hydrogenation had occurred from the β-face. Thus the structures assigned to lycoctamone and its analogues have been confirmed.
The structure of (9) contains a unique pentacyclic ring system (Fig. 1) that has not been reported in any stucture contained in the latest version of Cambridge Structural Database (2006 Release, Allen, 2002). The six-membered rings C1—C5/C11 (ring A), C5–C7/C9–C11 (ring B), C7–C11/C17 (ring C) and C4/C5/C11/C17/C19/N1 (ring D) adopt chair, boat, boat and C11-envelope conformations, respectively. The five membered ring, C9/C10/C12–C14 (ring E) exhibits a C13-envelope conformation. The puckering parameters (Cremer & Pople, 1975) for ring A are Q = 0.562 (4) Å, θ = 167.7 (4)° and ϕ = 8(2)°. In ring B, atoms C7 and C11 lie 0.735 (5) and 0.709 (5) Å, respectively, out of the plane formed by the remaining four atoms of the ring, the maximum deviation of any of these fours atoms from the plane being 0.052 (2) Å. Similarly, in ring C, atoms C7 and C11 lie 0.735 (5) and 0.709 (5) Å, respectively, out of the plane formed by the remaining four atoms of the ring, with a maximum deviation of 0.082 (2) Å. In the heterocyclic ring D, atom C11 lies 0.720 (5) Å out of the plane formed by the remaining five atoms, which show large deviations from planarity [between 0.120 (2) and 0.146 (3) Å].
The molecular dimensions in (9) are as expected and the structure is stabilized by strong intermolecular hydrogen bonds of the type O—H···O, linking the molecules into spirals along the b direction; details of hydrogen-bonding geometry have been provided in Table 2.