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RNA helicases are indispensable for all organisms in each domain of life and have implications in numerous cellular processes. The DEAH-box RNA helicase Prp43 is involved in pre-mRNA splicing as well as rRNA maturation. Here, the crystal structure of Chaetomium thermophilum Prp43 at 2.9 Å resolution is revealed. Furthermore, it is demonstrated that Prp43 from C. thermophilum is capable of functionally replacing its orthologue from Saccharomyces cerevisiae in spliceosomal disassembly assays.

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Portable Document Format (PDF) file https://doi.org/10.1107/S2053230X15024498/no5098sup1.pdf
Supplementary figures and tables.

PDB reference: RNA helicase Prp43 from Chaetomium thermophilum bound to ADP, 5d0u


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