Figure 4
The mechanism of Mhp1 taken from Shimamura et al. (2010). The movements are delineated by arrows. A: Helix 10 bends over the substrate. B: The hash motif rotates by 30° around the rotation axis shown as a black line. C: The small extracellular helix moves to seal completely the extracellular side of the protein. D: Helix 5 bends to open the cavity on the intracellular side in a reciprocal manner to helix 10. |