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Figure 1
Cell proliferation and angiogenesis requires interaction between the cell and the extracellular matrix that is mediated by integrins. Endogenous RGD peptides bind to integrins and anchor migrating and dividing cells. The desired mode of action of RGD antagonists is to block endogenous RGD peptide binding, thus preventing continued cellular proliferation and angiogenesis.

Journal logoJOURNAL OF
SYNCHROTRON
RADIATION
ISSN: 1600-5775
Volume 20| Part 2| February 2013| Pages 226-233
doi:10.1107/S0909049513001647
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