**Figure 4**
C_{α}-normalized *D*_{loss} damage signature histogram plots over all atoms of specific residue types for (*a*, *b*) myrosinase, (*c*, *d*) malate dehydrogenase, (*e*, *f*) TRAP and (*g*, *h*) GH7. The normalization scheme is: C_{α}-normalized *D*_{loss}(atom) = [*D*_{loss}(atom) − ]/, where is the average *D*_{loss} calculated over the set of C_{α} atoms. Two residue types are directly compared in each plot: (*a*, *c*, *e*, *g*) Tyr and Phe, and (*b*, *d*, *f*, *h*) Asp and Asn. Gaussian kernel density estimates, which are non-parametric approximations of the probability density function underlying each *D*_{loss} distribution, are overlaid on the histogram plots. Highest dose datasets for each series are displayed; other doses within each series exhibit qualitatively similar behaviour. |