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Figure 7
Effect of ICp6-Cu and X-ray irradiation on DNA damage determined by γ-H2AX immunostaining. (a) Representative immunofluorescence images of NT8e (i) and 4451 (ii) cells treated without (upper panel) or with (lower panel) 30 µM ICp6-Cu at various time points post-irradiation (7 Gy). Images show cell nuclei in blue and γ-H2AX foci in red. (b) Number of γ-H2AX foci at 30 min post-irradiation (7 Gy) in NT8e and 4451 cells without or with ICp6-Cu treatment (30 µM). (c) Changes in percentage of γ-H2AX foci in NT8e (i) and 4451 (ii) cells treated with or without 30 µM ICp6-Cu at different time periods post-irradiation (7 Gy), indicating repair kinetics of DSBs. Data represent mean ± standard deviation obtained from three independent experiments. *(p < 0.05), **(p < 0.01) indicate statistical significance between X-rays alone and ICp6-Cu plus X-ray treatment.

Journal logoJOURNAL OF
SYNCHROTRON
RADIATION
ISSN: 1600-5775
Volume 24| Part 6| November 2017| Pages 1265-1275
https://doi.org/10.1107/S1600577517012711
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