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![[Figure 1]](gm5051fig1mag.jpg)
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Figure 1
The results of the ICA for glucose isomerase (GI) mapped onto 1XIB. The metal-binding residues in the active site are labelled with magenta, while the residues involved in substrate binding are labelled yellow. (a) dρ/dD maps of specific radiation-induced changes at different temperatures. All maps are contoured at ±5σ, with the exception of the 100 K map, which is contoured at ±4.5σ. Red colour represents loss of electron density and green colour represents gain of electron density. (b) Map of the first component of the ICA contoured at ±5σ with red colour representing loss of electron density and green colour representing gain of electron density. The map represents the common part of the specific radiation-induced changes between all data analysed. As this is the common part between the data collected at different temperatures, it is equivalent to the changes that are independent of temperature, so it is interpreted as a map of (dρ/dD) type. (c) ![[\partial^2\rho/\partial DT]](teximages/gm5051fi5.gif) map of the second component of the ICA, contoured at ±4σ and representing those specific radiation-induced changes that vary with temperature. Grey colour denotes the decrease in the rate of specific radiation damage with change of temperature, while orange denotes the increase in the rate of specific radiation damage with change of temperature. |
![[Figure 1]](gm5051fig1.jpg)
 | JOURNAL OF SYNCHROTRON RADIATION |
ISSN: 1600-5775
