Figure 1
General schematic of LTGFβ-1 activation to show the LTGFβ-1 complex and the activation releasing TGFβ-1. In the latent complex form, the N-terminal α1 helix and latency-lasso segments of the straightjacket domain of LAP cage TGFβ-1, maintain latency and prevent receptor binding (Shi et al., 2011). |