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Figure 6
Modelling of SAXS to an ensemble of conformations reveals that LAP exists predominantly in an extended conformation. (a) A Kratky plot comparing experimental SAXS profiles for LTGFβ-1 and LAP shows that LAP is more flexible. (b) The maximum particle dimension (Dmax) of the EOM random pool (blue) and of the ensemble that best explains the LAP scattering data (gold). (c) The radius of gyration (Rg) of the EOM random pool (blue) and of the ensemble (gold). (d) The LAP domain from the LTGFβ-1 crystal structure (blue; latency helix, purple; glycosylation, various) superimposed with models from the selected ensemble (gold, light blue, green, light purple).

Journal logoJOURNAL OF
SYNCHROTRON
RADIATION
ISSN: 1600-5775
Volume 26| Part 4| July 2019| Pages 967-979
https://doi.org/10.1107/S1600577519005113
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