Figure 3
The protein crystal conformational ensemble at ambient temperature is not dominated by global radiation damage [adapted from Russi et al. (2017)]. Analysis of conformational disorder with increasing radiation dose for three proteins. The slopes correspond to a linear regression of the number of distinct alternate conformers onto average diffraction weighted dose (Zeldin et al., 2013), with p-values reported at 95% confidence levels. The results did not identify a significant trend between dose and the observed protein conformational ensemble at cryogenic and room temperatures. |