Modification of the Langendorff system of the isolated beating heart for experimental radiotherapy at a synchrotron: 4000 Gy in a heart beat

Schültke, E.; Lerch, M.; Kirschstein, T.; Lange, F.; Porath, K.; Fiedler, S.; Davis, J.; Paino, J.; Engels, E.; Barnes, M.; Klein, M.; Hall, C.; Häusermann, D.; Hildebrandt, G.

doi:10.1107/S1600577522004489

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Figure 3
(a) Setup of the Langendorff heart, recording coronary perfusion pressure, temperature, electrocardiogram (ECG) and left ventricular pressure. (b₁) ECG (black traces), left ventricular pressure (blue traces), time course of the heart rate (HR) and enlarged ECG during baseline before irradiation (HR; HRV: heart rate variability; ΔLVP: change in left ventricular pressure). (b₂) ECG (black traces), left ventricular pressure (blue traces), time course of the heart rate (HR) and enlarged ECG during irradiation and early post-irradiation. A transient increase of left ventricular pressure was observed in this phase. (b₃) ECG (black traces), left ventricular pressure (blue traces), time course of the HR and enlarged ECG at different post-irradiation time points. The heart rate completely returned to pre-irradiation baseline values within 60 min after MBI. (c) NE challenge ECG before and after irradiation (left) and heart rate (right). Norepinephrine (NE) still increased the heart rate after irradiation.

JOURNAL OF
SYNCHROTRON
RADIATION

ISSN: 1600-5775

Volume 29| Part 4| July 2022| Pages 1027-1032

https://doi.org/10.1107/S1600577522004489

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