Response of pheochromocytoma neuronal cells to varying intensity of continuous wave terahertz radiation

Linklater, D.P.; Perera, P.G.T.; Vilagosh, Z.; Perez-Gonzalez, A.; Le, P.H.; Sharma, T.; Leeming, M.G.; Williamson, N.A.; Appadoo, D.; Croft, R.; Ivanova, E.P.

doi:10.1107/S1600577525008227

Figure 6
Scheme of the potential molecular/biological processes affected by non-ionizing THz radiation. The activation of the CaN complex occurs swiftly in response to an influx of intracellular calcium (Ca²⁺), playing a crucial role in the dephosphorylation of various important substrates. CaN is known to dephosphorylate the microtubule-associated proteins Mapt and MAP2. Dephosphorylation of the Tau proteins (Mapt and MAP2) by CaN is associated with cellular response to oxidative stress (Zambrano et al., 2004

). Mitochondrial translocases 1 and 2 make up part of the mitochondrial permeability transition pore complex (2 out of 7 proteins). Transitional pore openings in the inner mitochondrial membrane are linked to mitochondrial dysfunction caused by mitochondrial depolarization, cessation of ATP synthesis, Ca²⁺ release, pyridine nucleotide depletion, inhibition of respiration and matrix swelling. Short-term openings may be involved in the physiological regulation of Ca²⁺ and ROS homeostasis and provide mitochondria with a fast mechanism for Ca²⁺ release, which could be a possible trigger due to SS THz radiation and as shown by previous findings where THz irradiation drove the activation of voltage-gated calcium (Ca²⁺) channels.

JOURNAL OF
SYNCHROTRON
RADIATION

ISSN: 1600-5775

Volume 32| Part 6| November 2025| Pages 1431-1444

https://doi.org/10.1107/S1600577525008227

Open

access

Search IUCr Journals		doi		Advanced search
Author		volume	page