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Figure 6
From the 1949 penicillin monograph: photograph of electron-density contours drawn on sheets of perspex showing the thiazolidine and β-lactam of potassium benzylpenicillin (Crowfoot et al., 1949aBB48). Owing to urgency created by the `extreme importance of penicillin as a military weapon' in WWII, determining the crystal structure of penicillin involved the first crystallographic use in Britain of a Hollerith computer; with Dorothy Hodgkin-Crowfoot as lead crystallographer and with Leslie J. Comrie's Scientific Computing Services Ltd developing the computing methodology. As noted in the penicillin monograph: `Under the terms of the contract for the publication of the Chemistry of Penicillin the publisher has agreed to waive its rights under the copyright after five years from the date of publication. Thereafter this volume will be in the public domain and dedicated to the public.'

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ISSN: 2053-2733
Volume 64| Part 1| January 2008| Pages 65-87
https://doi.org/10.1107/S0108767307051355
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