Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules

Nomme, J.; Murphy, J.M.; Su, Y.; Sansone, N.D.; Armijo, A.L.; Olson, S.T.; Radu, C.; Lavie, A.

doi:10.1107/S1399004713025030

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 1
Schematic of the dCK inhibitors and their apparent IC₅₀ values. (a) Schematic diagram of the F-series family of compounds and the nature of the substituent at the 5-position of the thiazole ring. (b) Data and curve fit used to determine the IC₅₀^app values. (c) IC₅₀^app values, errors and coefficients of determination (R²).

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 70| Part 1| December 2014| Pages 68-78

doi:10.1107/S1399004713025030

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