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![[Figure 5]](mn5051fig5mag.jpg)
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Figure 5
(a) Cartoon representation of a monomer of the human LDH-A binary complex (purple) with NADH (grey) with positions of sequence variation among mammalian LDH-A enzymes shown as sticks and coloured in orange. Selected residues in close proximity to the active site are labelled. (b) Superposition of the human LDH-A apo form (purple) with LDH-A apo structures from spiny dogfish (cyan; PDB entry 6ldh; 0.45 Å r.m.s.d., 79% sequence identity; Abad-Zapatero et al., 1987  ) and ice mackerel (light blue; PDB entry 2v65; 0.6 Å r.m.s.d., 71% sequence identity; Coquelle et al., 2007). |
![[Figure 5]](mn5051fig5.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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