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Acta Cryst. (2008). E64, o1920    [ doi:10.1107/S160053680802864X ]

3-(4-Methoxyphenyl)-1-(2-pyrrolyl)prop-2-en-1-one

D.-Q. Li

Abstract top

The title molecule, C14H13NO2, is almost flat with a dihedral angle of 8.0 (1)° between the pyrrole and benzene rings. The central C3O ketone unit has an s-cis conformation and is also coplanar with a torsion angle of -0.6 (3) °. An intramolecular C-H...O hydrogen bond generates an S(5) ring motif. In addition, the methoxy group is coplanar with the attached benzene ring. In the crystal structure, neighboring molecules are paired through N-H...O hydrogen bonds into centrosymmetric dimers with an R22(10) motif.

Comment top

Chalcone derivatives have recently attracted extensive interest due to possessing a wide variety of pharmaceutical (Lin et al., 2002; Modzelewska et al., 2006; Sogawa et al., 1994) and biological properties (Opletalova, 2000; Opletalova & Sedivy, 1999). Some substituted chalcones also exhibit the potential applications as non-linear optical materials (Agrinskaya et al., 1999; Indira et al., 2002). Considering the importance of these types of compounds, a new chalcone compound was synthesized and its crystal structure is reported here.

The molecular structure of the title molecule (Fig. 1) is almost planar as indicated by a dihedral angle of 8.0 (1) ° between the pyrrole and benzene rings. The central O1/C5/C6/C7 ketone motif exhibits an s-cis conformation as usual in other related chalcone derivatives (Bukhari et al., 2008; Fun et al., 2008; Gong, et al., 2008;) and also coplanar with a torsion angle of -0.6 (3) °, meanwhile, O1 atom acts as an acceptor and is involved in an intramolecular C—H···O hydrogen bond (Table 1) to generate an S(5) ring motif. In the crystal packing, the compound can be stabilized by intermolecular N—H···O hydrogen bonds with –NH groups as donors to form centrosymmetric dimers with an R22(10) motif as shown in Fig. 2.

Related literature top

For the pharmaceutical and biological properties of chalcones, see: Lin et al. (2002); Modzelewska et al. (2006); Opletalova (2000); Opletalova & Sedivy (1999); Sogawa et al. (1994). For chalcones as non-linear optical materials, see: Agrinskaya et al. (1999); Indira et al. (2002). For other related literature, see: (Bukhari et al. (2008); Fun et al. (2008); Gong, et al. (2008).

Experimental top

The title compound was synthesized by the condensation of 2-acetylpyrrole (1.09 g, 10.0 mmol) and 4-methoxybenzaldehyde (1.06 g, 5.0 mmol) in methanol (30 ml) and ammonia (25%, 25 ml) in the presence of sodium hydroxide (0.56 g, 10 mmol). After refluxed at 358 K for 8 h, the contents of the flask were cooled to give a yellow crude precipitate which was separated by filtration, washed with water and iced ethanol. Recrystallization from ethanol afforded yellow prism-like crystals. Yield: 0.85 g (74.8%).

Refinement top

All H-atoms were positioned geometrically and refined using a riding model with d(C—H) = 0.93 Å, Uiso=1.2Ueq (C) for aromatic and ethylene; 0.96 Å, Uiso= 1.5Ueq (C) for CH3 atoms, and d(N—H) = 0.86 Å, Uiso=1.2Ueq (N) for pyrrole nitrogen atom.

Computing details top

Data collection: SMART (Bruker, 2002); cell refinement: SAINT (Bruker, 2002); data reduction: SAINT (Bruker, 2002); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXTL (Sheldrick, 2008).

Figures top
[Figure 1] Fig. 1. The molecular structure of the title compound with displacement ellipsoids drawn at the 30% probability level and H atoms as spheres of arbitrary radius.
[Figure 2] Fig. 2. Packing diagram of the title structure showing the N—H···.O hydrogen bonding interactions.
3-(4-Methoxyphenyl)-1-(2-pyrrolyl)prop-2-en-1-one top
Crystal data top
C14H13NO2F(000) = 480
Mr = 227.25Dx = 1.250 Mg m−3
Monoclinic, P21/cMo Kα radiation, λ = 0.71073 Å
Hall symbol: -P 2ybcCell parameters from 1716 reflections
a = 5.0815 (7) Åθ = 2.4–25.8°
b = 17.172 (3) ŵ = 0.08 mm−1
c = 13.973 (2) ÅT = 293 K
β = 97.878 (3)°Prism, yellow
V = 1207.8 (3) Å30.40 × 0.24 × 0.20 mm
Z = 4
Data collection top
Bruker APEX area-detector
diffractometer		2369 independent reflections
Radiation source: fine-focus sealed tube1809 reflections with I > 2σ(I)
graphiteRint = 0.020
φ and ω scansθmax = 26.0°, θmin = 1.9°
Absorption correction: multi-scan
(SADABS; Sheldrick, 1996)		h = −6→5
Tmin = 0.967, Tmax = 0.988k = −20→21
5842 measured reflectionsl = −14→17
Refinement top
Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.047Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.124H-atom parameters constrained
S = 1.05 w = 1/[σ2(Fo2) + (0.0557P)2 + 0.1497P]
where P = (Fo2 + 2Fc2)/3
2369 reflections(Δ/σ)max < 0.001
155 parametersΔρmax = 0.13 e Å−3
0 restraintsΔρmin = −0.13 e Å−3
Crystal data top
C14H13NO2V = 1207.8 (3) Å3
Mr = 227.25Z = 4
Monoclinic, P21/cMo Kα radiation
a = 5.0815 (7) ŵ = 0.08 mm−1
b = 17.172 (3) ÅT = 293 K
c = 13.973 (2) Å0.40 × 0.24 × 0.20 mm
β = 97.878 (3)°
Data collection top
Bruker APEX area-detector
diffractometer		2369 independent reflections
Absorption correction: multi-scan
(SADABS; Sheldrick, 1996)		1809 reflections with I > 2σ(I)
Tmin = 0.967, Tmax = 0.988Rint = 0.020
5842 measured reflectionsθmax = 26.0°
Refinement top
R[F2 > 2σ(F2)] = 0.047H-atom parameters constrained
wR(F2) = 0.124Δρmax = 0.13 e Å−3
S = 1.05Δρmin = −0.13 e Å−3
2369 reflectionsAbsolute structure: ?
155 parametersFlack parameter: ?
0 restraintsRogers parameter: ?
Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/Ueq
N1−0.2188 (3)0.56328 (8)0.38761 (9)0.0567 (4)
H1−0.19760.54370.44480.068*
O10.1957 (3)0.45435 (7)0.40994 (8)0.0707 (4)
O20.9171 (3)0.29580 (8)−0.06480 (9)0.0769 (4)
C1−0.0745 (3)0.54326 (9)0.31541 (10)0.0520 (4)
C2−0.1690 (4)0.58892 (10)0.23690 (12)0.0634 (5)
H2−0.10820.58850.17710.076*
C3−0.3705 (4)0.63554 (11)0.26280 (13)0.0707 (5)
H3−0.46880.67210.22380.085*
C4−0.3978 (3)0.61792 (11)0.35599 (12)0.0634 (5)
H4−0.52020.64010.39160.076*
C50.1294 (3)0.48406 (9)0.32984 (11)0.0535 (4)
C60.2491 (3)0.45958 (10)0.24510 (11)0.0570 (4)
H60.19130.48340.18620.068*
C70.4347 (3)0.40549 (10)0.24796 (11)0.0556 (4)
H70.49090.38350.30810.067*
C80.5616 (3)0.37631 (9)0.16757 (11)0.0517 (4)
C90.7403 (3)0.31532 (10)0.17995 (11)0.0578 (4)
H90.77890.29300.24090.069*
C100.8645 (3)0.28594 (10)0.10527 (12)0.0586 (4)
H100.98270.24450.11600.070*
C110.8105 (3)0.31894 (10)0.01503 (11)0.0563 (4)
C120.6337 (4)0.38052 (11)0.00062 (12)0.0714 (5)
H120.59780.4033−0.06020.086*
C130.5110 (4)0.40830 (11)0.07518 (12)0.0669 (5)
H130.39150.44940.06390.080*
C141.0982 (4)0.23244 (12)−0.05485 (15)0.0873 (6)
H14A1.24450.2445−0.00600.131*
H14B1.16310.2235−0.11530.131*
H14C1.00940.1866−0.03650.131*
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
N10.0611 (8)0.0626 (9)0.0479 (7)−0.0046 (7)0.0129 (6)−0.0043 (6)
O10.0880 (9)0.0760 (8)0.0520 (7)0.0121 (7)0.0233 (6)0.0115 (6)
O20.0977 (9)0.0780 (9)0.0577 (7)0.0310 (7)0.0207 (7)0.0018 (6)
C10.0533 (9)0.0579 (10)0.0459 (8)−0.0089 (7)0.0107 (7)−0.0036 (7)
C20.0698 (11)0.0717 (12)0.0499 (9)0.0006 (9)0.0120 (8)0.0007 (8)
C30.0771 (12)0.0731 (12)0.0605 (11)0.0098 (10)0.0042 (9)0.0001 (9)
C40.0606 (10)0.0670 (11)0.0630 (10)0.0017 (9)0.0098 (8)−0.0132 (9)
C50.0581 (9)0.0570 (10)0.0468 (8)−0.0110 (8)0.0120 (7)0.0004 (7)
C60.0610 (10)0.0631 (10)0.0480 (8)−0.0034 (8)0.0112 (7)0.0020 (7)
C70.0607 (10)0.0594 (10)0.0473 (8)−0.0088 (8)0.0097 (7)0.0029 (7)
C80.0562 (9)0.0501 (9)0.0492 (8)−0.0053 (7)0.0084 (7)0.0006 (7)
C90.0609 (10)0.0617 (11)0.0499 (9)0.0015 (8)0.0049 (8)0.0112 (7)
C100.0583 (10)0.0567 (10)0.0604 (10)0.0089 (8)0.0062 (8)0.0056 (8)
C110.0636 (10)0.0549 (10)0.0507 (9)0.0046 (8)0.0096 (8)−0.0014 (7)
C120.0972 (14)0.0701 (12)0.0473 (9)0.0254 (11)0.0115 (9)0.0082 (8)
C130.0855 (13)0.0608 (11)0.0553 (10)0.0232 (9)0.0137 (9)0.0050 (8)
C140.1013 (15)0.0851 (14)0.0779 (13)0.0345 (13)0.0212 (11)−0.0047 (11)
Geometric parameters (Å, °) top
N1—C41.339 (2)C7—C81.459 (2)
N1—C11.3699 (19)C7—H70.9300
N1—H10.8600C8—C91.382 (2)
O1—C51.2342 (18)C8—C131.394 (2)
O2—C111.3644 (19)C9—C101.386 (2)
O2—C141.419 (2)C9—H90.9300
C1—C21.380 (2)C10—C111.375 (2)
C1—C51.446 (2)C10—H100.9300
C2—C31.386 (2)C11—C121.384 (2)
C2—H20.9300C12—C131.371 (2)
C3—C41.362 (2)C12—H120.9300
C3—H30.9300C13—H130.9300
C4—H40.9300C14—H14A0.9600
C5—C61.465 (2)C14—H14B0.9600
C6—C71.320 (2)C14—H14C0.9600
C6—H60.9300
C4—N1—C1109.93 (14)C9—C8—C13116.70 (15)
C4—N1—H1125.0C9—C8—C7121.10 (14)
C1—N1—H1125.0C13—C8—C7122.20 (15)
C11—O2—C14117.91 (14)C8—C9—C10122.74 (15)
N1—C1—C2106.24 (15)C8—C9—H9118.6
N1—C1—C5121.30 (14)C10—C9—H9118.6
C2—C1—C5132.46 (15)C11—C10—C9119.07 (15)
C1—C2—C3108.04 (15)C11—C10—H10120.5
C1—C2—H2126.0C9—C10—H10120.5
C3—C2—H2126.0O2—C11—C10125.29 (15)
C4—C3—C2107.26 (17)O2—C11—C12115.23 (14)
C4—C3—H3126.4C10—C11—C12119.48 (15)
C2—C3—H3126.4C13—C12—C11120.59 (16)
N1—C4—C3108.52 (15)C13—C12—H12119.7
N1—C4—H4125.7C11—C12—H12119.7
C3—C4—H4125.7C12—C13—C8121.42 (16)
O1—C5—C1121.24 (14)C12—C13—H13119.3
O1—C5—C6121.48 (16)C8—C13—H13119.3
C1—C5—C6117.27 (14)O2—C14—H14A109.5
C7—C6—C5123.47 (15)O2—C14—H14B109.5
C7—C6—H6118.3H14A—C14—H14B109.5
C5—C6—H6118.3O2—C14—H14C109.5
C6—C7—C8127.43 (15)H14A—C14—H14C109.5
C6—C7—H7116.3H14B—C14—H14C109.5
C8—C7—H7116.3
C4—N1—C1—C20.86 (18)C6—C7—C8—C9−175.31 (17)
C4—N1—C1—C5−178.71 (14)C6—C7—C8—C135.0 (3)
N1—C1—C2—C3−0.38 (19)C13—C8—C9—C10−0.4 (3)
C5—C1—C2—C3179.11 (17)C7—C8—C9—C10179.89 (15)
C1—C2—C3—C4−0.2 (2)C8—C9—C10—C110.6 (3)
C1—N1—C4—C3−1.01 (19)C14—O2—C11—C100.2 (3)
C2—C3—C4—N10.7 (2)C14—O2—C11—C12−179.46 (18)
N1—C1—C5—O1−6.2 (2)C9—C10—C11—O2−179.72 (16)
C2—C1—C5—O1174.32 (17)C9—C10—C11—C12−0.1 (3)
N1—C1—C5—C6172.35 (14)O2—C11—C12—C13179.16 (17)
C2—C1—C5—C6−7.1 (3)C10—C11—C12—C13−0.5 (3)
O1—C5—C6—C7−0.6 (3)C11—C12—C13—C80.6 (3)
C1—C5—C6—C7−179.16 (15)C9—C8—C13—C12−0.2 (3)
C5—C6—C7—C8178.75 (15)C7—C8—C13—C12179.49 (16)
Hydrogen-bond geometry (Å, °) top
D—H···AD—HH···AD···AD—H···A
C7—H7···O10.932.522.838 (2)100.
N1—H1···O1i0.862.032.8314 (17)155.
Symmetry codes: (i) −x, −y+1, −z+1.
Table 1
Hydrogen-bond geometry (Å, °) top
D—H···AD—HH···AD···AD—H···A
C7—H7···O10.932.522.838 (2)100.
N1—H1···O1i0.862.032.8314 (17)155.
Symmetry codes: (i) −x, −y+1, −z+1.
Acknowledgements top

The authors thank Yulin Normal University for supporting this study.

references
References top

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