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November 2020 issue
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Cover illustration: Lattice-translocation defects in toad neuraminidase [Li et al. (2020), Acta Cryst. D76, 1057-1064]. Neuraminidase (NA) inhibitors are one of the two major classes of antivirals available for the treatment and prevention of influenza. X-ray crystal structure determination of NA head domains and their complexes with various inhibitors are of importance for the design and optimization of anti-influenza drugs. However, the globular tetrameric properties of NA head domains may produce crystals with pathological imperfections, lattice-translocation defects, making structure determination no longer straightforward. Here a crystal of the NA head domain from the Wuhan Asiatic toad influenza virus provides an example of the identification and solution of this type of crystal pathology.
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