Interactive segmentation of membrane and membrane-mimic densities in cryo-EM maps

SURFER performs automated segmentation of contextual membrane and membrane-mimic density in cryo-EM maps to enable robust separation of macromolecular signal from surrounding detergent or lipid–membrane features. It is conveniently distributed as a plugin for UCSF ChimeraX, allowing interactive application within standard map-visualization workflows.

PETIMOT: a novel framework for inferring protein motions from sparse data using SE(3)-equivariant graph neural networks

We present a new formulation for protein flexibility and learn protein motions from sparse experimental data.

Experimental estimation of copper-site geometry reproducibility in biologically relevant redox and saccharide-bound states of a model lytic polysaccharide monooxygenase

Small but measurable changes in the coordination geometry of a lytic polysaccharide monooxygenase copper active site are revealed by X-ray crystallography, providing structural insight into their catalytic flexibility.

Crystal structure of endo-β-1,6-galactanase from Streptomyces avermitilis

The crystal structure of S. avermitilis endo-β-1,6-galactanase belonging to GH30 subfamily 5 reveals the first structural framework for endo-β-1,6-galactanase. The β-1,6-galactobiose-bound complex identifies the catalytic subsites and a distal secondary sugar-binding site, providing insight into β-1,6-galactan recognition.

Structural basis for a p21-activated kinase 4 and nicotinamide phosphoribosyltransferase dual inhibitor

The 2-aminopyridine moiety of KPT-7523 binds p21-activated kinase 4 and nicotinamide phosphoribosyltransferase, enabling a versatile design for multi-target cancer therapy.

Protein Data Bank (PDB) Archive: a new architecture (beta) for scalable, PDBx/mmCIF-based data distribution

wwPDB has extended PDB IDs to 12 characters with a prefix `pdb_' followed by eight alphanumeric characters in lower case (for example pdb_1000axyz). A beta version of the PDB Archive (https://files-beta.wwpdb.org), with extended PDB IDs and an improved directory structure, is now available to help communities adopt extended PDB IDs and the PDBx/mmCIF format.

Optimal 1TEL–target protein linker character is target protein-dependent. Corrigendum

The article by Pedroza Romo et al. [(2026), Acta Cryst. D82, 516–532] is corrected.