Crystal structure and Hirshfeld surface analysis of 5-acetyl-2-amino-4-(4-bromo­phen­yl)-6-oxo-1-phenyl-1,4,5,6-tetra­hydro­pyridine-3-carbo­nitrile

Mamedov, I.G.; Khrustalev, V.N.; Akkurt, M.; Novikov, A.P.; Asgarova, A.R.; Aliyeva, K.N.; Akobirshoeva, A.A.

doi:10.1107/S2056989022001232

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ISSN: 2056-9890

Volume 78| Part 3| March 2022| Pages 291-296

https://doi.org/10.1107/S2056989022001232

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Crystal structure and Hirshfeld surface analysis of 5-acetyl-2-amino-4-(4-bromophenyl)-6-oxo-1-phenyl-1,4,5,6-tetrahydropyridine-3-carbonitrile

Ibrahim G. Mamedov,^a Victor N. Khrustalev,^b,^c Mehmet Akkurt,^d Anton P. Novikov,^b Ayten R. Asgarova,^a Khatira N. Aliyeva ^a and Anzurat A. Akobirshoeva ^e ^*

^aDepartment of Chemistry, Baku State University, 23 Z. Khalilov str., Az, 1148 Baku, Azerbaijan, ^bPeoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklay str., Moscow, 117198, Russian Federation, ^cN. D. Zelinsky Institute of Organic Chemistry RAS, Leninsky Prosp. 47, 119991 Moscow, Russian Federation, ^dDepartment of Physics, Faculty of Sciences, Erciyes University, 38039 Kayseri, Turkey, and ^eAcad. Sci. Republ. Tajikistan, Kh. Yu. Yusufbekov Pamir Biol. Inst., 1 Kholdorova str., 736002, Khorog, Gbao, Tajikistan
^*Correspondence e-mail: anzurat2003@mail.ru

Edited by A. V. Yatsenko, Moscow State University, Russia (Received 24 January 2022; accepted 1 February 2022; online 3 February 2022)

The crystal structure of the title compound, C₂₀H₁₆BrN₃O₂, was determined using an inversion twin. Its asymmetric unit comprises two crystallographically independent molecules (A and B) being the stereoisomers. Both molecules are linked by pairs of N—H⋯O hydrogen bonds, forming a dimer with an R²₂(16) ring motif. The dimers are connected by further N—H⋯O and N—H⋯N hydrogen bonds, forming chains along the c-axis direction·C—Br⋯π interactions between these chains contribute to the stabilization of the molecular packing. Hirshfeld surface analysis showed that the most important contributions to the crystal packing are from H⋯H, C⋯H/H⋯C, O⋯H/H⋯O, Br⋯H/H⋯Br and N⋯H/H⋯N interactions.

Keywords: crystal structure; tetrahydropyridine; hydrogen bonds; dimers; C—Br⋯π contacts; Hirshfeld surface analysis.

CCDC reference: 2149629

1. Chemical context

Nitrogen-based heterocycles are an important class of organic molecules that are used extensively in different branches of chemistry (Yadigarov et al., 2009 ; Abdelhamid et al., 2011 ; Magerramov et al., 2018 ; Yin et al., 2020 ; Khalilov et al., 2021 ). In particular, the synthesis of heterocyclic systems comprising a bioactive pyridine core with a broad spectrum of biological activities is noteworthy (Mamedov et al., 2020 ; Wojcicka & Redzicka, 2021 ). On the other hand, the pyridine ring is an essential part of diverse natural products, such as nicotinic acid, nicotinamide, vitamin B₃ and diverse alkaloids (Aida et al., 2009 ). In the framework of our ongoing structural studies (Safarova et al., 2019 ; Naghiyev et al., 2020 , 2021a ,b ; Maharramov et al., 2021 ), we report here the crystal structure and Hirshfeld surface analysis of the title compound, 5-acetyl-2-amino-4-(4-bromophenyl)-6-oxo-1-phenyl-1,4,5,6-tetrahydropyridine-3-carbonitrile.

2. Structural commentary

The title compound crystallizes in the monoclinic space group Pc with Z = 4, and with two molecules, A and B, in the asymmetric unit (Fig. 1). These molecules are stereoisimers with an R,R absolute configurations at C3 and C4 in molecule A, whereas the corresponding atoms in B, C23 and C24, have an S configuration. In both molecules, the conformation of the central dihydropyridine ring is close to screw-boat [the puckering parameters (Cremer & Pople, 1975 ) are θ = 63.9 (11)°, φ = 148.9 (12)° in A and θ = 115.1 (11)°, φ = 339.4 (12)° in B]. In molecule A, the phenyl (C7–C12) and bromophenyl (C14–C19) rings form dihedral angles of 64.0 (4) and 86.3 (4)°, respectively, with the mean plane of the central dihydropyridine ring. In molecule B, the corresponding dihedral angles are 77.2 (4) and 83.9 (4)°. The acetyl groups in both molecules are almost planar [largest deviations of 0.005 (8) and 0.035 (8) Å for atoms C1 (A) and C23 (B), respectively] and they make the dihedral angles of 89.5 (5) and 87.7 (5)° with the mean planes of the dihydropyridine rings in these molecules.

Figure 1
Asymmetric unit of the title compounds showing two crystallographically independent molecules, A and B. Displacement ellipsoids are drawn at the 30% probability level. The intermolecular N—H⋯O hydrogen bonds are drawn with dashed lines.

3. Supramolecular features

Strong N6—H6B⋯O21 and N26—H26A⋯O1 hydrogen bonds (Fig. 1, Table 1) link molecules A and B into dimers with an $[R_{2}^{2}]$ (16) ring motif (Bernstein et al., 1995 ). These dimers are additionally stabilized by C=O⋯π interactions [O21⋯Cg2 = 3.620 (8) Å, C21=O21⋯Cg2 = 110.8 (6)°, O1⋯Cg5 = 3.748 (8) Å, C1=O1⋯Cg5 = 125.1 (6)°, where Cg2 and Cg5 are the centroids of the C7–C12 phenyl ring in molecule A and the C27–C32 phenyl ring in molecule B, respectively]. The dimers are connected by N—H⋯O and N—H⋯N hydrogen bonds with an R₃³(14) ring motif into chains along the c-axis direction (Table 1; Figs. 2, 3, 4 and 5). C—Br⋯π interactions are also observed [Br1⋯Cg6^v = 3.407 (4) Å, C17—Br1⋯Cg6^v = 145.2 (3)°; symmetry code (v) −1 + x, 1 − y, − $[{1\over 2}]$ + z; Cg6 is the centroid of the C34–C39 ring]. Together with the other intermolecular contacts given in Table 2, these interactions contribute to the stabilization of the molecular packing, forming a three-dimensional network (Figs. 6 and 7).

Table 1
Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
N6—H6A⋯O2ⁱ	0.90	1.87	2.766 (9)	175
N6—H6B⋯O21	0.90	2.31	3.115 (9)	149
C18—H18⋯N40ⁱⁱ	0.95	2.46	3.256 (12)	141
C23—H23⋯N40ⁱⁱⁱ	1.00	2.47	3.426 (11)	161
N26—H26A⋯O1	0.90	1.99	2.784 (9)	146
N26—H26B⋯N20^iv	0.90	2.43	3.139 (10)	136
Symmetry codes: (i) $[x, -y+1, z+{\script{1\over 2}}]$ ; (ii) ; (iii) $[x, -y+2, z+{\script{1\over 2}}]$ ; (iv) $[x, -y+1, z-{\script{1\over 2}}]$ .

Table 2
Summary of short interatomic contacts (Å) in the title compound

Contact	Distance	Symmetry operation
O2⋯H30	2.63	x − 1, −y + 1, z − $[{1\over 2}]$
O1⋯H26A	1.99	x, y, z
H13C⋯H16	2.46	x + 1, y, z
O2⋯H6A	1.87	x, −y + 1, z − $[{1\over 2}]$
H18⋯N40	2.46	x, y − 1, z
N20⋯H26B	2.43	x, −y + 1, z + $[{1\over 2}]$
C9⋯Br2	3.377 (10)	x − 1, −y + 2, z − $[{1\over 2}]$
H13C⋯O22	2.79	x, −y + 1, z − $[{1\over 2}]$
C16⋯H36	2.86	x − 1, y − 1, z
H11⋯H26A	2.47	x − 1, y, z
O21⋯H31	2.84	x − 1, y, z
H23⋯N40	2.47	x, −y + 2, z + $[{1\over 2}]$
H31⋯O21	2.84	x + 1, y, z

Figure 2
A general view of the N—H⋯O and N—H⋯N hydrogen bonds in the structure of the title compound.

Figure 3
The crystal packing of the title compound viewed down the a axis, showing chains running along the c-axis direction formed through N—H⋯O and N—H⋯N hydrogen bonds.

Figure 4
The crystal packing of the title compound viewed down the b axis, showing chains running along the c axis formed through N—H⋯O and N—H⋯N hydrogen bonds.

Figure 5
The crystal packing of the title compound viewed down the c axis, with intermolecular N—H⋯O, C—H⋯N and N—H⋯N hydrogen bonds.

Figure 6
The C—Br⋯π and C=O⋯π interactions in the structure of the title compound viewed down the a axis.

Figure 7
A view of the C—Br⋯π and C=O⋯π interactions in the structure of the title compound viewed down the b axis.

4. Hirshfeld surface analysis

To visualize the intermolecular interactions for both independent molecules A and B, CrystalExplorer17 (Turner et al., 2017 ) was used to generate Hirshfeld surfaces and corresponding two-dimensional fingerprint plots. The d_norm mappings were performed in the range of −0.6596 to 1.4042 arbitrary units for molecule A and −0.5436 to 1.4926 arbitrary units for molecule B. Bright red circles on the d_norm surfaces (Fig. 8a,b,c,d) indicate regions of N—H⋯O interactions. The N—H⋯N and C—H⋯N interactions (Tables 1 and 2) also cause red spots on the Hirshfeld surfaces.

Figure 8
Front and back views of the Hirshfeld surfaces mapped over d_norm for molecule A (a, b) and molecule B (c, d).

The fingerprint plots (Fig. 9) reveal that while the H⋯H interactions make the greatest contributions (Table 3), as would be expected for a molecule with such a predominance of H atoms, C⋯H/H⋯C, O⋯H/H⋯O, Br⋯H/H⋯Br and N⋯H/H⋯N contacts are also substantial. Table 3 gives the contributions of the other, less significant contacts. The fact that the same type of interactions provide different contributions to the Hirshfeld surface for molecules A and B can be attributed to the different environments of these molecules in the crystalline state.

Table 3
Percentage contributions of interatomic contacts to the Hirshfeld surfaces of molecules A and B of the title compound

Contact	Contribution for A	Contribution for B
H⋯H	32.8	33.8
C⋯H/H⋯C	19.6	18.9
O⋯H/H⋯O	17.2	13.5
Br⋯H/H⋯Br	10.6	11.3
N⋯H/H⋯N	9.4	14.0
Br⋯C/C⋯Br	4.8	4.6
N⋯O/O⋯N	2.1	–
C⋯O/O⋯C	1.4	1.3
Br⋯O/O⋯Br	0.8	0.9
C⋯C	0.7	0.7
N⋯N	0.5	0.4
Br⋯N/N⋯Br	0.1	0.6

Figure 9
The two-dimensional fingerprint plots [(a) for molecule A and (b) for molecule B], showing all interactions and those delineated into H⋯H, C⋯H/H⋯C, O⋯H/H⋯O, Br⋯H/H⋯Br, N⋯H/H⋯N interactions. The d_i and d_e values are the closest internal and external distances (in Å) from given points on the Hirshfeld surfaces.

5. Database survey

A search of the Cambridge Structural Database (CSD, Version 5.42, update of September 2021; Groom et al., 2016 ) for the tetrahydropyridine unit gave 1340 hits, and some of which, namely OZAKOS (Naghiyev et al., 2021c ), JEBREQ (Mohana et al., 2017 ), JEBRAM (Mohana et al., 2017), SETWUK (Suresh et al., 2007 ) and SETWOE (Suresh et al., 2007) closely resemble the title compound.

In OZAKOS (space group: Pc), the molecular conformation of the title compound is stabilized by an intramolecular O—H⋯O hydrogen bond, forming an S(6) ring motif. In the crystal, molecules are linked by intermolecular N—H⋯N and C—H⋯N hydrogen bonds, and N—H⋯π and C—H⋯π interactions, forming a three-dimensional network.

In both the related salts, JEBREQ (space group: P $[\overline{1}]$ ) and JEBRAM (space group: P $[\overline{1}]$ ), the N atom in the 1-position of the pyrimidine ring is protonated. In the hydrated salt JEBREQ, the presence of the water molecule prevents the formation of the familiar $[R_{2}^{2}]$ (8) ring motif. Instead, an expanded ring [i.e. R³₂(8)] is formed involving the sulfonate group, the pyrimidinium cation and the water molecule. Both salts form a supramolecular homosynthon [ $[R_{2}^{2}]$ (8) ring motif] through N—H⋯N hydrogen bonds. The molecular structures are further stabilized by π–π stacking, and C=O⋯π, C—H⋯O and C—H⋯Cl interactions. It appears that the protonation state of the pyrimidine ring influences the intermolecular interactions within the crystal lattice to a substantial extent. In JEBRAM, the protonated N atom and the amino group of the pyrimidinium cation interact with the carboxylate group of the anion through N—H⋯O hydrogen bonds, forming a heterosynthon with an $[R_{2}^{2}]$ (8) ring motif.

The polysubstituted pyridines, SETWUK (space group: P2₁/n) and SETWOE (space group: P2₁/c), adopt nearly planar structures. The crystal structure of SETWUK is stabilized by intermolecular C—H⋯F and C—H⋯π interactions. The C—H⋯F bond generates a linear chain with a C(14) motif. The crystal structure of SETWOE is stabilized by intermolecular C—H⋯O and C—H⋯π interactions. The C—H⋯O hydrogen bonds generate rings with R²₂(14) and R²₂(20) motifs. In addition, in SETWOE and SETWUK, intramolecular O—H⋯O interactions are found, which generate an S(6) graph-set motif. No significant aryl–aryl or π–π interactions exist in these structures. All this bears some resemblance to the title compound.

6. Synthesis and crystallization

To a solution of 2-(4-bromobenzylidene)malononitrile (1.19 g; 5.1 mmol) and acetoacetanilide (0.92 g; 5.2 mmol) in methanol (25 mL), piperidine (2–3 drops) was added and the mixture was stirred at room temperature for 48 h. Then 15 mL of methanol were removed by rotary evaporation from the reaction mixture, which was left overnight. The precipitated crystals were separated by filtration and recrystallized from ethanol/water (1:1) solution (yield 66%; m.p. 536–537 K).

¹H NMR (300 MHz, DMSO-d₆, m.h.): 2.29 (s, 3H, CH₃—C=O); 4.15 (d, 1H, CH-Ar); 4.34 (d, 1H, CH—C=O); 5.98 (s, 2H, NH₂); 7.12–7.35 (m, 5H, 5CH_ar); 7.40 (d, 2H, 2CH_ar); 7.61 (d, 2H, 2CH_ar).

¹³C NMR (75 MHz, DMSO-d₆, m.h.): 27.86 (CH₃—C=O), 37.94 (CH—Ar), 57.24 (=C_quat), 62.41 (CH—C=O), 117.21 (CN), 121.25 (Br-Car), 127.67 (CH_ar), 128.19 (2CH_ar), 129.58 (2CH_ar), 130.15 (2CH_ar), 130.74 (2CH_ar), 136.98 (C_ar), 140.37 (C_ar), 154.14 (=C_quat), 166.20 (N—C=O), 202.55 (C=O).

7. Refinement details

Crystal data, data collection and structure refinement details are summarized in Table 4. All H atoms were positioned geometrically (N—H = 0.90 Å, C—H = 0.95–1.00 Å) and refined as riding with U_iso(H) = 1.2U_eq(C, N) or 1.5U_eq(C-methyl).

Table 4
Experimental details

Crystal data
Chemical formula	C₂₀H₁₆BrN₃O₂
M_r	410.26
Crystal system, space group	Monoclinic, Pc
Temperature (K)	100
a, b, c (Å)	9.5889 (7), 13.2144 (10), 14.4529 (10)
β (°)	103.9395 (18)
V (Å³)	1777.4 (2)
Z	4
Radiation type	Mo Kα
μ (mm⁻¹)	2.33
Crystal size (mm)	0.05 × 0.04 × 0.03

Data collection
Diffractometer	Bruker D8 QUEST PHOTON-III CCD
Absorption correction	Multi-scan (SADABS; Krause et al., 2015 )
T_min, T_max	0.818, 0.926
No. of measured, independent and observed [I > 2σ(I)] reflections	34410, 10756, 5403
R_int	0.099
(sin θ/λ)_max (Å⁻¹)	0.714

Refinement
R[F² > 2σ(F²)], wR(F²), S	0.065, 0.132, 0.98
No. of reflections	10756
No. of parameters	471
No. of restraints	2
H-atom treatment	H-atom parameters constrained
Δρ_max, Δρ_min (e Å⁻³)	0.50, −0.66
Absolute structure	Refined as an inversion twin
Absolute structure parameter	0.473 (14)
Computer programs: CrysAlis PRO (Rigaku OD, 2021 $[Rigaku OD (2021). CrysAlis PRO. Rigaku Oxford Diffraction, Yarnton, England.]$ ), SHELXT (Sheldrick, 2015a ), SHELXL (Sheldrick, 2015b ), ORTEP-3 for Windows (Farrugia, 2012 ) and PLATON (Spek, 2020 ).

Supporting information

CCDC reference: 2149629

Crystal structure: contains datablock I. DOI: https://doi.org/10.1107/S2056989022001232/yk2165sup1.cif

Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S2056989022001232/yk2165Isup2.hkl

Supporting information file. DOI: https://doi.org/10.1107/S2056989022001232/yk2165Isup3.cml

checkCIF report

Computing details top

Data collection: CrysAlis PRO (Rigaku OD, 2021); cell refinement: CrysAlis PRO (Rigaku OD, 2021); data reduction: CrysAlis PRO (Rigaku OD, 2021); program(s) used to solve structure: SHELXT (Sheldrick, 2015a); program(s) used to refine structure: SHELXL (Sheldrick, 2015b); molecular graphics: ORTEP-3 for Windows (Farrugia, 2012); software used to prepare material for publication: PLATON (Spek, 2020).

5-Acetyl-2-amino-4-(4-bromophenyl)-6-oxo-1-phenyl-1,4,5,6-tetrahydropyridine-3-carbonitrile top

Crystal data top

C₂₀H₁₆BrN₃O₂	F(000) = 832
M_r = 410.26	D_x = 1.533 Mg m⁻³
Monoclinic, Pc	Mo Kα radiation, λ = 0.71073 Å
a = 9.5889 (7) Å	Cell parameters from 3126 reflections
b = 13.2144 (10) Å	θ = 2.7–24.0°
c = 14.4529 (10) Å	µ = 2.33 mm⁻¹
β = 103.9395 (18)°	T = 100 K
V = 1777.4 (2) Å³	Prism, colourless
Z = 4	0.05 × 0.04 × 0.03 mm

Data collection top

Bruker D8 QUEST PHOTON-III CCD diffractometer	5403 reflections with I > 2σ(I)
φ and ω scans	R_int = 0.099
Absorption correction: multi-scan (SADABS; Krause et al., 2015)	θ_max = 30.5°, θ_min = 2.1°
T_min = 0.818, T_max = 0.926	h = −13→13
34410 measured reflections	k = −18→18
10756 independent reflections	l = −20→20

Refinement top

Refinement on F²	Hydrogen site location: mixed
Least-squares matrix: full	H-atom parameters constrained
R[F² > 2σ(F²)] = 0.065	w = 1/[σ²(F_o²) + (0.0401P)²] where P = (F_o² + 2F_c²)/3
wR(F²) = 0.132	(Δ/σ)_max < 0.001
S = 0.98	Δρ_max = 0.50 e Å⁻³
10756 reflections	Δρ_min = −0.66 e Å⁻³
471 parameters	Extinction correction: SHELXL, Fc^*=kFc[1+0.001xFc²λ³/sin(2θ)]^-1/4
2 restraints	Extinction coefficient: 0.0039 (3)
Primary atom site location: difference Fourier map	Absolute structure: Refined as an inversion twin
Secondary atom site location: difference Fourier map	Absolute structure parameter: 0.473 (14)

Special details top

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

Refinement. Refined as a two-component inversion twin.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²) top

	x	y	z	U_iso*/U_eq
Br1	−0.05184 (9)	0.02892 (6)	0.27044 (7)	0.0328 (2)
N1	0.3304 (7)	0.5094 (5)	0.4197 (5)	0.0194 (15)
C1	0.6385 (9)	0.4260 (6)	0.3992 (6)	0.0216 (19)
O1	0.6581 (7)	0.5145 (5)	0.4155 (5)	0.0456 (19)
C2	0.3768 (9)	0.4655 (6)	0.3455 (6)	0.0219 (18)
O2	0.3284 (7)	0.4954 (4)	0.2642 (4)	0.0273 (14)
C3	0.4864 (9)	0.3816 (6)	0.3708 (6)	0.0211 (18)
H3	0.4792	0.3389	0.3127	0.025*
C4	0.4547 (9)	0.3140 (6)	0.4498 (6)	0.0221 (19)
H4	0.5405	0.2699	0.4736	0.026*
C5	0.4402 (9)	0.3820 (6)	0.5310 (6)	0.0229 (19)
C6	0.3781 (9)	0.4741 (6)	0.5141 (6)	0.0213 (18)
N6	0.3596 (7)	0.5398 (5)	0.5816 (5)	0.0219 (15)
H6A	0.3529	0.5257	0.6413	0.026*
H6B	0.3534	0.6055	0.5646	0.026*
C7	0.2213 (9)	0.5898 (6)	0.3983 (6)	0.0212 (18)
C8	0.2595 (10)	0.6844 (7)	0.3737 (7)	0.031 (2)
H8	0.3538	0.6970	0.3663	0.037*
C9	0.1581 (10)	0.7610 (7)	0.3600 (7)	0.036 (2)
H9	0.1814	0.8267	0.3416	0.044*
C10	0.0223 (11)	0.7409 (8)	0.3732 (7)	0.036 (2)
H10	−0.0463	0.7940	0.3661	0.044*
C11	−0.0144 (11)	0.6464 (7)	0.3963 (6)	0.035 (2)
H11	−0.1089	0.6334	0.4031	0.042*
C12	0.0861 (10)	0.5691 (7)	0.4099 (6)	0.030 (2)
H12	0.0620	0.5030	0.4269	0.036*
C13	0.7611 (10)	0.3551 (6)	0.4072 (7)	0.034 (2)
H13A	0.7314	0.2868	0.4207	0.050*
H13B	0.8413	0.3770	0.4591	0.050*
H13C	0.7915	0.3546	0.3472	0.050*
C14	0.3267 (9)	0.2446 (6)	0.4069 (6)	0.0213 (17)
C15	0.1891 (10)	0.2670 (6)	0.4115 (7)	0.029 (2)
H15	0.1720	0.3262	0.4445	0.034*
C16	0.0740 (10)	0.2057 (6)	0.3695 (6)	0.029 (2)
H16	−0.0213	0.2229	0.3717	0.034*
C17	0.1025 (10)	0.1185 (6)	0.3240 (6)	0.026 (2)
C18	0.2390 (10)	0.0940 (6)	0.3159 (7)	0.029 (2)
H18	0.2561	0.0350	0.2828	0.035*
C19	0.3494 (10)	0.1581 (6)	0.3576 (6)	0.026 (2)
H19	0.4441	0.1428	0.3525	0.031*
C20	0.4925 (10)	0.3499 (6)	0.6274 (7)	0.024 (2)
N20	0.5390 (9)	0.3255 (6)	0.7052 (5)	0.0335 (19)
Br2	1.05193 (11)	1.25495 (8)	0.62011 (8)	0.0409 (3)
N2	0.6616 (7)	0.7734 (5)	0.5811 (5)	0.0220 (16)
C21	0.3521 (10)	0.8636 (7)	0.5959 (6)	0.028 (2)
O21	0.3329 (8)	0.7728 (5)	0.6051 (5)	0.0403 (18)
C22	0.6085 (10)	0.8245 (6)	0.6505 (6)	0.027 (2)
O22	0.6450 (7)	0.8015 (4)	0.7343 (4)	0.0305 (15)
C23	0.5025 (9)	0.9077 (6)	0.6148 (6)	0.0238 (19)
H23	0.5119	0.9588	0.6670	0.029*
C24	0.5288 (9)	0.9623 (6)	0.5266 (6)	0.0226 (19)
H24	0.4424	1.0048	0.4993	0.027*
C25	0.5389 (9)	0.8820 (6)	0.4542 (6)	0.0230 (19)
C26	0.6117 (9)	0.7941 (6)	0.4838 (6)	0.0210 (18)
N26	0.6426 (8)	0.7245 (5)	0.4234 (5)	0.0279 (17)
H26A	0.6602	0.6614	0.4466	0.034*
H26B	0.6454	0.7409	0.3634	0.034*
C27	0.7687 (10)	0.6958 (6)	0.6136 (6)	0.0234 (19)
C28	0.7276 (10)	0.6009 (6)	0.6383 (7)	0.030 (2)
H28	0.6293	0.5858	0.6336	0.036*
C29	0.8324 (11)	0.5287 (7)	0.6698 (7)	0.040 (3)
H29	0.8056	0.4632	0.6865	0.048*
C30	0.9761 (11)	0.5507 (6)	0.6776 (7)	0.033 (2)
H30	1.0476	0.5007	0.6998	0.040*
C31	1.0139 (11)	0.6444 (7)	0.6530 (7)	0.035 (2)
H31	1.1123	0.6590	0.6575	0.042*
C32	0.9120 (10)	0.7187 (6)	0.6216 (6)	0.028 (2)
H32	0.9398	0.7842	0.6059	0.034*
C33	0.2270 (11)	0.9361 (7)	0.5651 (8)	0.041 (3)
H33A	0.2541	1.0027	0.5936	0.061*
H33B	0.1440	0.9103	0.5862	0.061*
H33C	0.2021	0.9422	0.4955	0.061*
C34	0.6606 (8)	1.0327 (6)	0.5511 (6)	0.0188 (17)
C35	0.7743 (10)	1.0222 (7)	0.5076 (6)	0.028 (2)
H35	0.7720	0.9690	0.4630	0.034*
C36	0.8913 (10)	1.0875 (7)	0.5276 (7)	0.029 (2)
H36	0.9687	1.0787	0.4980	0.035*
C37	0.8931 (10)	1.1659 (6)	0.5917 (6)	0.026 (2)
C38	0.7802 (10)	1.1788 (6)	0.6350 (6)	0.027 (2)
H38	0.7820	1.2325	0.6789	0.033*
C39	0.6654 (10)	1.1133 (6)	0.6139 (6)	0.025 (2)
H39	0.5874	1.1232	0.6429	0.030*
C40	0.4888 (10)	0.8997 (6)	0.3553 (7)	0.025 (2)
N40	0.4482 (10)	0.9142 (5)	0.2749 (6)	0.0307 (16)

Atomic displacement parameters (Å²) top

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
Br1	0.0341 (5)	0.0228 (4)	0.0388 (5)	−0.0033 (5)	0.0036 (4)	−0.0037 (5)
N1	0.027 (4)	0.020 (3)	0.012 (3)	0.005 (3)	0.007 (3)	0.002 (3)
C1	0.027 (5)	0.016 (4)	0.025 (5)	0.002 (4)	0.013 (4)	−0.003 (3)
O1	0.030 (4)	0.026 (4)	0.081 (5)	−0.002 (3)	0.013 (4)	−0.012 (4)
C2	0.025 (5)	0.017 (4)	0.026 (5)	−0.001 (4)	0.013 (4)	−0.005 (4)
O2	0.035 (4)	0.025 (3)	0.021 (3)	−0.001 (3)	0.006 (3)	0.004 (3)
C3	0.028 (5)	0.018 (4)	0.018 (4)	0.001 (4)	0.006 (4)	−0.005 (3)
C4	0.031 (5)	0.019 (4)	0.015 (4)	−0.002 (4)	0.004 (4)	0.001 (3)
C5	0.031 (5)	0.021 (4)	0.018 (4)	−0.001 (4)	0.008 (4)	0.001 (3)
C6	0.026 (5)	0.020 (4)	0.020 (4)	−0.004 (4)	0.010 (4)	−0.006 (4)
N6	0.031 (4)	0.021 (4)	0.015 (4)	−0.003 (3)	0.008 (3)	−0.001 (3)
C7	0.024 (5)	0.020 (4)	0.019 (4)	0.004 (3)	0.003 (4)	0.000 (3)
C8	0.027 (5)	0.023 (4)	0.043 (6)	−0.001 (4)	0.010 (5)	0.002 (4)
C9	0.039 (6)	0.031 (5)	0.035 (6)	0.012 (5)	0.000 (5)	0.003 (4)
C10	0.036 (6)	0.042 (6)	0.030 (6)	0.014 (5)	0.006 (5)	−0.005 (5)
C11	0.039 (6)	0.033 (5)	0.037 (6)	0.010 (5)	0.017 (5)	0.000 (4)
C12	0.026 (5)	0.030 (5)	0.033 (5)	0.002 (4)	0.008 (4)	0.005 (4)
C13	0.029 (5)	0.028 (5)	0.044 (6)	−0.001 (4)	0.010 (5)	−0.002 (4)
C14	0.024 (5)	0.019 (4)	0.021 (4)	0.000 (4)	0.006 (4)	0.002 (4)
C15	0.041 (6)	0.015 (4)	0.032 (5)	−0.002 (4)	0.012 (5)	0.000 (4)
C16	0.031 (5)	0.018 (4)	0.040 (6)	−0.003 (4)	0.014 (5)	−0.006 (4)
C17	0.027 (5)	0.025 (5)	0.023 (5)	−0.008 (4)	0.001 (4)	0.002 (4)
C18	0.031 (5)	0.020 (4)	0.037 (6)	0.002 (4)	0.008 (5)	−0.003 (4)
C19	0.022 (5)	0.030 (5)	0.029 (5)	−0.001 (4)	0.010 (4)	−0.007 (4)
C20	0.032 (5)	0.015 (4)	0.024 (5)	0.002 (4)	0.006 (4)	−0.001 (4)
N20	0.045 (5)	0.031 (4)	0.025 (5)	0.011 (4)	0.009 (4)	0.001 (3)
Br2	0.0417 (6)	0.0460 (6)	0.0350 (5)	−0.0143 (5)	0.0092 (4)	−0.0033 (5)
N2	0.020 (4)	0.017 (4)	0.026 (4)	0.006 (3)	0.000 (3)	0.002 (3)
C21	0.035 (6)	0.027 (5)	0.023 (5)	0.004 (4)	0.008 (4)	0.000 (4)
O21	0.051 (5)	0.026 (4)	0.048 (5)	−0.004 (3)	0.021 (4)	0.000 (3)
C22	0.038 (6)	0.016 (4)	0.025 (5)	−0.003 (4)	0.005 (4)	0.001 (4)
O22	0.044 (4)	0.025 (3)	0.023 (3)	0.003 (3)	0.008 (3)	0.003 (3)
C23	0.027 (5)	0.018 (4)	0.029 (5)	0.002 (4)	0.012 (4)	−0.003 (4)
C24	0.029 (5)	0.013 (4)	0.025 (5)	0.003 (4)	0.007 (4)	−0.001 (3)
C25	0.031 (5)	0.021 (4)	0.019 (4)	0.004 (4)	0.010 (4)	0.001 (4)
C26	0.028 (5)	0.013 (4)	0.023 (5)	0.001 (3)	0.007 (4)	−0.004 (3)
N26	0.034 (4)	0.022 (4)	0.030 (4)	0.006 (3)	0.011 (4)	0.000 (3)
C27	0.031 (5)	0.018 (4)	0.022 (5)	0.008 (4)	0.007 (4)	−0.001 (3)
C28	0.026 (5)	0.019 (4)	0.040 (6)	−0.002 (4)	0.003 (4)	0.006 (4)
C29	0.041 (6)	0.023 (5)	0.050 (6)	0.004 (5)	−0.001 (5)	0.012 (5)
C30	0.039 (6)	0.023 (5)	0.038 (6)	0.011 (4)	0.009 (5)	−0.001 (4)
C31	0.033 (6)	0.038 (6)	0.034 (6)	0.005 (4)	0.005 (5)	−0.003 (4)
C32	0.035 (5)	0.022 (4)	0.028 (5)	0.006 (4)	0.009 (4)	0.002 (4)
C33	0.039 (6)	0.035 (5)	0.050 (7)	0.006 (5)	0.015 (5)	0.004 (5)
C34	0.017 (4)	0.018 (4)	0.020 (4)	0.003 (3)	0.003 (3)	0.005 (3)
C35	0.037 (6)	0.022 (5)	0.025 (5)	0.003 (4)	0.009 (4)	0.001 (4)
C36	0.028 (5)	0.031 (5)	0.030 (5)	0.003 (4)	0.010 (4)	0.001 (4)
C37	0.031 (5)	0.020 (4)	0.026 (5)	−0.004 (4)	0.003 (4)	0.003 (4)
C38	0.039 (6)	0.024 (4)	0.018 (5)	0.000 (4)	0.005 (4)	0.000 (4)
C39	0.031 (5)	0.017 (4)	0.025 (5)	0.004 (4)	0.004 (4)	0.002 (4)
C40	0.036 (5)	0.013 (4)	0.028 (5)	0.008 (4)	0.012 (4)	0.000 (4)
N40	0.039 (4)	0.027 (4)	0.030 (4)	0.010 (4)	0.014 (3)	0.008 (4)

Geometric parameters (Å, º) top

Br1—C17	1.908 (9)	Br2—C37	1.890 (9)
N1—C2	1.383 (10)	N2—C26	1.400 (10)
N1—C6	1.410 (10)	N2—C22	1.403 (11)
N1—C7	1.470 (10)	N2—C27	1.447 (10)
C1—O1	1.199 (9)	C21—O21	1.226 (10)
C1—C13	1.486 (12)	C21—C33	1.516 (12)
C1—C3	1.533 (12)	C21—C23	1.517 (12)
C2—O2	1.220 (10)	C22—O22	1.215 (10)
C2—C3	1.511 (11)	C22—C23	1.501 (11)
C3—C4	1.537 (11)	C23—C24	1.538 (11)
C3—H3	1.0000	C23—H23	1.0000
C4—C5	1.510 (11)	C24—C25	1.509 (11)
C4—C14	1.538 (11)	C24—C34	1.541 (11)
C4—H4	1.0000	C24—H24	1.0000
C5—C6	1.351 (11)	C25—C26	1.369 (11)
C5—C20	1.428 (12)	C25—C40	1.414 (12)
C6—N6	1.349 (10)	C26—N26	1.350 (10)
N6—H6A	0.8999	N26—H26A	0.8993
N6—H6B	0.9000	N26—H26B	0.9000
C7—C8	1.374 (11)	C27—C32	1.384 (12)
C7—C12	1.374 (12)	C27—C28	1.387 (11)
C8—C9	1.385 (12)	C28—C29	1.380 (12)
C8—H8	0.9500	C28—H28	0.9500
C9—C10	1.387 (13)	C29—C30	1.386 (14)
C9—H9	0.9500	C29—H29	0.9500
C10—C11	1.361 (13)	C30—C31	1.362 (12)
C10—H10	0.9500	C30—H30	0.9500
C11—C12	1.386 (12)	C31—C32	1.382 (12)
C11—H11	0.9500	C31—H31	0.9500
C12—H12	0.9500	C32—H32	0.9500
C13—H13A	0.9800	C33—H33A	0.9800
C13—H13B	0.9800	C33—H33B	0.9800
C13—H13C	0.9800	C33—H33C	0.9800
C14—C15	1.370 (12)	C34—C35	1.391 (11)
C14—C19	1.391 (11)	C34—C39	1.392 (11)
C15—C16	1.386 (12)	C35—C36	1.389 (13)
C15—H15	0.9500	C35—H35	0.9500
C16—C17	1.386 (12)	C36—C37	1.386 (12)
C16—H16	0.9500	C36—H36	0.9500
C17—C18	1.380 (12)	C37—C38	1.385 (12)
C18—C19	1.376 (12)	C38—C39	1.375 (12)
C18—H18	0.9500	C38—H38	0.9500
C19—H19	0.9500	C39—H39	0.9500
C20—N20	1.151 (11)	C40—N40	1.149 (11)

C2—N1—C6	121.4 (7)	C26—N2—C22	121.9 (7)
C2—N1—C7	119.0 (7)	C26—N2—C27	120.6 (7)
C6—N1—C7	119.4 (7)	C22—N2—C27	117.5 (7)
O1—C1—C13	121.1 (8)	O21—C21—C33	121.4 (9)
O1—C1—C3	121.3 (8)	O21—C21—C23	121.1 (8)
C13—C1—C3	117.6 (7)	C33—C21—C23	117.4 (8)
O2—C2—N1	119.5 (7)	O22—C22—N2	121.6 (8)
O2—C2—C3	123.4 (7)	O22—C22—C23	122.3 (8)
N1—C2—C3	117.1 (7)	N2—C22—C23	116.1 (7)
C2—C3—C1	110.2 (6)	C22—C23—C21	108.4 (7)
C2—C3—C4	110.8 (7)	C22—C23—C24	113.3 (7)
C1—C3—C4	111.6 (7)	C21—C23—C24	111.6 (7)
C2—C3—H3	108.0	C22—C23—H23	107.8
C1—C3—H3	108.0	C21—C23—H23	107.8
C4—C3—H3	108.0	C24—C23—H23	107.8
C5—C4—C3	107.7 (6)	C25—C24—C23	107.2 (6)
C5—C4—C14	117.0 (7)	C25—C24—C34	113.4 (7)
C3—C4—C14	109.2 (7)	C23—C24—C34	112.5 (7)
C5—C4—H4	107.5	C25—C24—H24	107.8
C3—C4—H4	107.5	C23—C24—H24	107.8
C14—C4—H4	107.5	C34—C24—H24	107.8
C6—C5—C20	118.7 (8)	C26—C25—C40	118.6 (8)
C6—C5—C4	120.9 (8)	C26—C25—C24	119.5 (7)
C20—C5—C4	120.4 (7)	C40—C25—C24	121.5 (7)
N6—C6—C5	125.3 (8)	N26—C26—C25	123.4 (8)
N6—C6—N1	114.7 (7)	N26—C26—N2	116.2 (7)
C5—C6—N1	119.9 (7)	C25—C26—N2	120.3 (7)
C6—N6—H6A	127.7	C26—N26—H26A	116.2
C6—N6—H6B	115.8	C26—N26—H26B	121.5
H6A—N6—H6B	116.5	H26A—N26—H26B	122.3
C8—C7—C12	122.1 (8)	C32—C27—C28	120.9 (8)
C8—C7—N1	119.4 (8)	C32—C27—N2	119.0 (8)
C12—C7—N1	118.4 (7)	C28—C27—N2	120.0 (8)
C7—C8—C9	118.7 (9)	C29—C28—C27	118.7 (9)
C7—C8—H8	120.6	C29—C28—H28	120.6
C9—C8—H8	120.6	C27—C28—H28	120.6
C8—C9—C10	119.4 (9)	C28—C29—C30	120.8 (9)
C8—C9—H9	120.3	C28—C29—H29	119.6
C10—C9—H9	120.3	C30—C29—H29	119.6
C11—C10—C9	121.1 (9)	C31—C30—C29	119.4 (9)
C11—C10—H10	119.5	C31—C30—H30	120.3
C9—C10—H10	119.5	C29—C30—H30	120.3
C10—C11—C12	120.0 (10)	C30—C31—C32	121.3 (9)
C10—C11—H11	120.0	C30—C31—H31	119.3
C12—C11—H11	120.0	C32—C31—H31	119.3
C7—C12—C11	118.7 (9)	C31—C32—C27	118.8 (8)
C7—C12—H12	120.7	C31—C32—H32	120.6
C11—C12—H12	120.7	C27—C32—H32	120.6
C1—C13—H13A	109.5	C21—C33—H33A	109.5
C1—C13—H13B	109.5	C21—C33—H33B	109.5
H13A—C13—H13B	109.5	H33A—C33—H33B	109.5
C1—C13—H13C	109.5	C21—C33—H33C	109.5
H13A—C13—H13C	109.5	H33A—C33—H33C	109.5
H13B—C13—H13C	109.5	H33B—C33—H33C	109.5
C15—C14—C19	118.3 (8)	C35—C34—C39	117.7 (8)
C15—C14—C4	122.4 (7)	C35—C34—C24	121.7 (7)
C19—C14—C4	119.3 (7)	C39—C34—C24	120.5 (7)
C14—C15—C16	121.8 (8)	C36—C35—C34	121.7 (8)
C14—C15—H15	119.1	C36—C35—H35	119.2
C16—C15—H15	119.1	C34—C35—H35	119.2
C15—C16—C17	117.8 (9)	C37—C36—C35	118.8 (9)
C15—C16—H16	121.1	C37—C36—H36	120.6
C17—C16—H16	121.1	C35—C36—H36	120.6
C18—C17—C16	122.3 (8)	C38—C37—C36	120.6 (9)
C18—C17—Br1	118.6 (7)	C38—C37—Br2	120.1 (7)
C16—C17—Br1	119.1 (7)	C36—C37—Br2	119.3 (7)
C19—C18—C17	117.6 (8)	C39—C38—C37	119.5 (8)
C19—C18—H18	121.2	C39—C38—H38	120.2
C17—C18—H18	121.2	C37—C38—H38	120.2
C18—C19—C14	122.1 (8)	C38—C39—C34	121.7 (8)
C18—C19—H19	119.0	C38—C39—H39	119.2
C14—C19—H19	119.0	C34—C39—H39	119.2
N20—C20—C5	177.7 (10)	N40—C40—C25	180.0 (14)

C6—N1—C2—O2	176.9 (8)	C26—N2—C22—O22	175.0 (8)
C7—N1—C2—O2	1.3 (11)	C27—N2—C22—O22	−3.7 (12)
C6—N1—C2—C3	−3.0 (11)	C26—N2—C22—C23	−4.0 (11)
C7—N1—C2—C3	−178.6 (7)	C27—N2—C22—C23	177.3 (7)
O2—C2—C3—C1	94.4 (10)	O22—C22—C23—C21	−86.3 (10)
N1—C2—C3—C1	−85.7 (9)	N2—C22—C23—C21	92.7 (9)
O2—C2—C3—C4	−141.5 (8)	O22—C22—C23—C24	149.1 (8)
N1—C2—C3—C4	38.4 (10)	N2—C22—C23—C24	−31.9 (10)
O1—C1—C3—C2	13.1 (12)	O21—C21—C23—C22	−3.8 (12)
C13—C1—C3—C2	−167.8 (7)	C33—C21—C23—C22	176.2 (8)
O1—C1—C3—C4	−110.6 (10)	O21—C21—C23—C24	121.7 (9)
C13—C1—C3—C4	68.5 (10)	C33—C21—C23—C24	−58.3 (10)
C2—C3—C4—C5	−52.2 (9)	C22—C23—C24—C25	51.6 (9)
C1—C3—C4—C5	71.1 (9)	C21—C23—C24—C25	−71.1 (8)
C2—C3—C4—C14	75.8 (8)	C22—C23—C24—C34	−73.7 (9)
C1—C3—C4—C14	−160.9 (7)	C21—C23—C24—C34	163.5 (7)
C3—C4—C5—C6	36.6 (11)	C23—C24—C25—C26	−40.8 (10)
C14—C4—C5—C6	−86.8 (10)	C34—C24—C25—C26	83.9 (9)
C3—C4—C5—C20	−143.3 (8)	C23—C24—C25—C40	146.4 (8)
C14—C4—C5—C20	93.4 (10)	C34—C24—C25—C40	−88.9 (10)
C20—C5—C6—N6	−0.5 (14)	C40—C25—C26—N26	2.2 (13)
C4—C5—C6—N6	179.6 (8)	C24—C25—C26—N26	−170.8 (8)
C20—C5—C6—N1	177.6 (8)	C40—C25—C26—N2	−179.3 (8)
C4—C5—C6—N1	−2.3 (13)	C24—C25—C26—N2	7.7 (12)
C2—N1—C6—N6	161.5 (7)	C22—N2—C26—N26	−163.9 (7)
C7—N1—C6—N6	−22.9 (10)	C27—N2—C26—N26	14.7 (11)
C2—N1—C6—C5	−16.8 (12)	C22—N2—C26—C25	17.5 (12)
C7—N1—C6—C5	158.8 (8)	C27—N2—C26—C25	−163.9 (8)
C2—N1—C7—C8	−73.8 (10)	C26—N2—C27—C32	81.3 (10)
C6—N1—C7—C8	110.5 (9)	C22—N2—C27—C32	−100.0 (9)
C2—N1—C7—C12	110.5 (9)	C26—N2—C27—C28	−100.2 (10)
C6—N1—C7—C12	−65.2 (10)	C22—N2—C27—C28	78.4 (10)
C12—C7—C8—C9	−0.2 (14)	C32—C27—C28—C29	−1.0 (14)
N1—C7—C8—C9	−175.7 (8)	N2—C27—C28—C29	−179.4 (8)
C7—C8—C9—C10	1.3 (14)	C27—C28—C29—C30	0.6 (15)
C8—C9—C10—C11	−2.2 (15)	C28—C29—C30—C31	−0.5 (16)
C9—C10—C11—C12	2.0 (15)	C29—C30—C31—C32	0.8 (15)
C8—C7—C12—C11	0.0 (14)	C30—C31—C32—C27	−1.2 (14)
N1—C7—C12—C11	175.6 (8)	C28—C27—C32—C31	1.3 (13)
C10—C11—C12—C7	−0.9 (14)	N2—C27—C32—C31	179.7 (8)
C5—C4—C14—C15	25.4 (12)	C25—C24—C34—C35	1.3 (11)
C3—C4—C14—C15	−97.2 (9)	C23—C24—C34—C35	123.2 (8)
C5—C4—C14—C19	−157.7 (8)	C25—C24—C34—C39	177.4 (7)
C3—C4—C14—C19	79.7 (9)	C23—C24—C34—C39	−60.7 (10)
C19—C14—C15—C16	0.6 (13)	C39—C34—C35—C36	1.9 (13)
C4—C14—C15—C16	177.5 (8)	C24—C34—C35—C36	178.1 (8)
C14—C15—C16—C17	1.6 (13)	C34—C35—C36—C37	−0.9 (14)
C15—C16—C17—C18	−2.9 (14)	C35—C36—C37—C38	0.0 (13)
C15—C16—C17—Br1	177.1 (7)	C35—C36—C37—Br2	179.7 (7)
C16—C17—C18—C19	1.9 (14)	C36—C37—C38—C39	−0.1 (13)
Br1—C17—C18—C19	−178.0 (7)	Br2—C37—C38—C39	−179.8 (6)
C17—C18—C19—C14	0.4 (14)	C37—C38—C39—C34	1.2 (13)
C15—C14—C19—C18	−1.6 (13)	C35—C34—C39—C38	−2.0 (12)
C4—C14—C19—C18	−178.7 (8)	C24—C34—C39—C38	−178.3 (8)

Hydrogen-bond geometry (Å, º) top

D—H···A	D—H	H···A	D···A	D—H···A
N6—H6A···O2ⁱ	0.90	1.87	2.766 (9)	175
N6—H6B···O21	0.90	2.31	3.115 (9)	149
C18—H18···N40ⁱⁱ	0.95	2.46	3.256 (12)	141
C23—H23···N40ⁱⁱⁱ	1.00	2.47	3.426 (11)	161
N26—H26A···O1	0.90	1.99	2.784 (9)	146
N26—H26B···N20^iv	0.90	2.43	3.139 (10)	136

Symmetry codes: (i) x, −y+1, z+1/2; (ii) x, y−1, z; (iii) x, −y+2, z+1/2; (iv) x, −y+1, z−1/2.

Summary of short interatomic contacts (Å) in the title compound top

Contact	Distance	Symmetry operation
O2···H30	2.63	x - 1, -y + 1, z - 1/2
O1···H26A	1.99	x, y, z
H13C···H16	2.46	x + 1, y, z
O2···H6A	1.87	x, -y + 1, z - 1/2
H18···N40	2.46	x, y - 1, z
N20···H26B	2.43	x, -y + 1, z + 1/2
C9···Br2	3.377 (10)	x - 1, -y + 2, z - 1/2
H13C···O22	2.79	x, -y + 1, z - 1/2
C16···H36	2.86	x - 1, y - 1, z
H11···H26A	2.47	x - 1, y, z
O21···H31	2.84	x - 1, y, z
H23···N40	2.47	x, -y + 2, z + 1/2
H31···O21	2.84	x + 1, y, z

Percentage contributions of interatomic contacts to the Hirshfeld surfaces of molecules A and B of the title compound top

Contact	Contribution for A	Contribution for B
H···H	32.8	33.8
C···H/H···C	19.6	18.9
O···H/H···O	17.2	13.5
Br···H/H···Br	10.6	11.3
N···H/H···N	9.4	14.0
Br···C/C···Br	4.8	4.6
N···O/O···N	2.1	–
C···O/O···C	1.4	1.3
Br···O/O···Br	0.8	0.9
C···C	0.7	0.7
N···N	0.5	0.4
Br···N/N···Br	0.1	0.6

Acknowledgements

Authors' contributions are as follows. Conceptualization and methodology, IGM; investigation, MA and APN; writing (original draft), MA and IGM; writing (review and editing of the manuscript), MA and ARA; visualization, MA and IGM; funding acquisition, VNK and IGM; resources, AAA, VNK and KNA; supervision, IGM and MA.

Funding information

This work was supported by the Baku State University, and RUDN University Strategic Academic Leadership Program.

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