Structure of the lutein-binding domain of human StARD3 at 1.74 Å resolution and model of a complex with lutein

Horvath, M.P.; George, E.W.; Tran, Q.T.; Baumgardner, K.; Zharov, G.; Lee, S.; Sharifzadeh, H.; Shihab, S.; Mattinson, T.; Li, B.; Bernstein, P.S.

doi:10.1107/S2053230X16010694

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 7
`Winner' lutein molecule docked with StARD3. (a) Overview of the StARD3_LBD structure shows the best-scoring lutein candidate from the `one portal' set. (b) Steric complementarity and a potential hydrogen bond to Gln421 are apparent outside portal 1 for the overall `winner' lutein molecule. (c) The `winner' lutein molecule positions the hydroxyl group of the ∊-ionone ring just inside portal 2, where it finds a potential hydrogen-bonding partner with the peptide bond connecting residues Ile301 and Leu302.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 72| Part 8| August 2016| Pages 609-618

doi:10.1107/S2053230X16010694

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