Figure 2
Overall structure of F. nucleatum apo N-acetylmannosamine kinase. The N-terminal domain is coloured in blue shades, the C-terminal dimerization domain in red shades and the the hinge loops are depicted in yellow. For clarity, based on the human hMNK structure (PDB entry 2yhy), ManNAc (green sticks), ADP (white sticks) and Mg2+ (blue sphere) have been modelled in the putative active site. |