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Figure 1
Overall structural comparison of SEB and S19. (a) LSQ superposition of the structures of MHC/TCB-bound SEB (green; PDB entry 4c56; Rödström et al., 2014BB15), unbound SEB (red; PDB entry 4rgm; Dutta et al., 2015BB20) and S19 (cyan). The original residues that are mutated in S19 are shown in stick form. (b) Structural changes in the flexible-loop region. The disulfide bridge between Cys93 and Cys113 is disrupted in the structure of S19. The C-terminal region of the loop region is not affected by the R110A mutation. (c) Side-chain structures related to the structural change. Tyr91 of S19 moves into the position occupied by Tyr90 in SEB, facilitated by hydrogen bonds to Asn60 and Asn88. Tyr89 does not move as a result of the Y90A mutation.

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 73| Part 11| November 2017| Pages 595-600
https://doi.org/10.1107/S2053230X17014844
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